A review of the clinical characteristics and management of immunosuppressed patients living with HIV or solid organ transplants infected with SARS-CoV-2 omicron variants
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron strain was first detected in South Africa in November 2021. Although clinical responses to SARS-CoV-2 depend on host immunity, it remains uncertain how immunosuppression affects subsequent coronavirus disease 2019-related (COVI...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1327093/full |
| _version_ | 1797300314578092032 |
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| author | Yan Song Lixin Lou Kaiyu Zhang Kaiyu Zhang |
| author_facet | Yan Song Lixin Lou Kaiyu Zhang Kaiyu Zhang |
| author_sort | Yan Song |
| collection | DOAJ |
| description | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron strain was first detected in South Africa in November 2021. Although clinical responses to SARS-CoV-2 depend on host immunity, it remains uncertain how immunosuppression affects subsequent coronavirus disease 2019-related (COVID-19-related) incidence, severity, and mortality, especially with respect to the omicron strain. Conversely, immunosuppressants are often thought to predispose to infection. To explore the associations between host immunity and infection with SARS-CoV-2 omicron variants, here we discuss two groups of immunosuppressed patients: organ transplant recipients, who generally receive exogenous immunosuppressants, and Human Immunodeficiency Virus (HIV)-infected patients, who often have disease-related immunosuppression. In summarizing the clinical features and prognoses of HIV-infected patients and human organ transplant recipients infected with SARS-CoV-2 omicron variants, we provide new insights into the pathogenesis of omicron SARS-CoV-2 and provide a framework for the management of these patients now and in the future. |
| first_indexed | 2024-03-07T23:05:29Z |
| format | Article |
| id | doaj.art-cb1dc982a6974a63bd0ef1150c758b61 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-07T23:05:29Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-cb1dc982a6974a63bd0ef1150c758b612024-02-22T05:15:47ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-02-011210.3389/fpubh.2024.13270931327093A review of the clinical characteristics and management of immunosuppressed patients living with HIV or solid organ transplants infected with SARS-CoV-2 omicron variantsYan Song0Lixin Lou1Kaiyu Zhang2Kaiyu Zhang3Department of Infectious Diseases, The First Hospital of Jilin University, Jilin, ChinaDepartment of Infectious Diseases, The First Hospital of Jilin University, Jilin, ChinaDepartment of Infectious Diseases, The First Hospital of Jilin University, Jilin, ChinaDepartment of Infectious Diseases and Center of Infectious Diseases and Pathogen Biology, The First Hospital of Jilin University, Changchun, ChinaThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron strain was first detected in South Africa in November 2021. Although clinical responses to SARS-CoV-2 depend on host immunity, it remains uncertain how immunosuppression affects subsequent coronavirus disease 2019-related (COVID-19-related) incidence, severity, and mortality, especially with respect to the omicron strain. Conversely, immunosuppressants are often thought to predispose to infection. To explore the associations between host immunity and infection with SARS-CoV-2 omicron variants, here we discuss two groups of immunosuppressed patients: organ transplant recipients, who generally receive exogenous immunosuppressants, and Human Immunodeficiency Virus (HIV)-infected patients, who often have disease-related immunosuppression. In summarizing the clinical features and prognoses of HIV-infected patients and human organ transplant recipients infected with SARS-CoV-2 omicron variants, we provide new insights into the pathogenesis of omicron SARS-CoV-2 and provide a framework for the management of these patients now and in the future.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1327093/fullimmunosuppressionHIVorgan transplantSARS-CoV-2 infectionomicroninflammation |
| spellingShingle | Yan Song Lixin Lou Kaiyu Zhang Kaiyu Zhang A review of the clinical characteristics and management of immunosuppressed patients living with HIV or solid organ transplants infected with SARS-CoV-2 omicron variants Frontiers in Public Health immunosuppression HIV organ transplant SARS-CoV-2 infection omicron inflammation |
| title | A review of the clinical characteristics and management of immunosuppressed patients living with HIV or solid organ transplants infected with SARS-CoV-2 omicron variants |
| title_full | A review of the clinical characteristics and management of immunosuppressed patients living with HIV or solid organ transplants infected with SARS-CoV-2 omicron variants |
| title_fullStr | A review of the clinical characteristics and management of immunosuppressed patients living with HIV or solid organ transplants infected with SARS-CoV-2 omicron variants |
| title_full_unstemmed | A review of the clinical characteristics and management of immunosuppressed patients living with HIV or solid organ transplants infected with SARS-CoV-2 omicron variants |
| title_short | A review of the clinical characteristics and management of immunosuppressed patients living with HIV or solid organ transplants infected with SARS-CoV-2 omicron variants |
| title_sort | review of the clinical characteristics and management of immunosuppressed patients living with hiv or solid organ transplants infected with sars cov 2 omicron variants |
| topic | immunosuppression HIV organ transplant SARS-CoV-2 infection omicron inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1327093/full |
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