SIRT1 mediates nutritional regulation of SREBP-1c-driven hepatic PNPLA3 transcription via modulation of H3k9 acetylation

SIRT1 mediates nutritional regulation of SREBP-1c-driven hepatic PNPLA3 transcription via modulation of H3k9 acetylation

Abstract Background Patatin-like phospholipase domain containing 3 (PNPLA3) is the main nonalcoholic fatty liver disease (NAFLD) susceptibility. Its expression is regulated tightly by nutritional and energy status, but the mechanism of epigenetic regulation of PNPLA3 gene by nutritional dietary fact...

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Bibliographic Details
Main Authors: Xiao Xu, Xiaojie Deng, Yunzhi Chen, Wen Xu, Fen Xu, Hua Liang
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Genes and Environment
Subjects:
SIRT1
PNPLA3
SREBP-1c
H3K9ac
Gene regulation
Online Access:https://doi.org/10.1186/s41021-022-00246-1

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