Distinct and separable roles for EZH2 in neurogenic astroglia

Distinct and separable roles for EZH2 in neurogenic astroglia

The epigenetic mechanisms that enable specialized astrocytes to retain neurogenic competence throughout adult life are still poorly understood. Here we show that astrocytes that serve as neural stem cells (NSCs) in the adult mouse subventricular zone (SVZ) express the histone methyltransferase EZH2....

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Bibliographic Details
Main Authors: William W Hwang, Ryan D Salinas, Jason J Siu, Kevin W Kelley, Ryan N Delgado, Mercedes F Paredes, Arturo Alvarez-Buylla, Michael C Oldham, Daniel A Lim
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-05-01
Series:eLife
Subjects:
EZH2
Polycomb
SVZ neurogenesis
glioma
astrocyte heterogeneity
OLIG2
Online Access:https://elifesciences.org/articles/02439

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