Frailty in Older Patients with End-Stage Renal Disease and Undergoing Chronic Haemodialysis in Vietnam
Background: There is limited evidence on the association between chronic kidney disease (CKD) and frailty in older people in Vietnam. This study aimed to investigate the prevalence of frailty and its impact on mortality in older patients with end-stage renal disease. Method: This is a prospective, o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Diabetology |
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| Online Access: | https://www.mdpi.com/2673-4540/4/3/27 |
| _version_ | 1797580632109350912 |
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| author | Tan Van Nguyen Thu Thi Xuan Pham Mason Jenner Burns Tu Ngoc Nguyen |
| author_facet | Tan Van Nguyen Thu Thi Xuan Pham Mason Jenner Burns Tu Ngoc Nguyen |
| author_sort | Tan Van Nguyen |
| collection | DOAJ |
| description | Background: There is limited evidence on the association between chronic kidney disease (CKD) and frailty in older people in Vietnam. This study aimed to investigate the prevalence of frailty and its impact on mortality in older patients with end-stage renal disease. Method: This is a prospective, observational study performed at two large Dialysis Centres in Vietnam from November 2020 to June 2021. Consecutive older patients diagnosed with end-stage renal disease and on haemodialysis were recruited. Participants’ frailty status was defined by the Clinical Frailty Scale (CFS). The study outcome was all-cause mortality at the sixth month. Results: A total of 175 participants were recruited (mean age 72.4 years, 58.9% female). Using the cut point of CFS ≥ 4, 87.4% of the participants were frail. Mortality at the sixth month was 14.9%, 31.9% in participants with CFS ≥ 7, 12.8% in participants with CFS = 6, 7.5% in participants with CFS from 4 to 5, and 4.5% in participants with CFS ≤ 3 (<i>p</i> = 0.001). Cox regression analysis showed that, compared with the non-frail participants, the probability of death over 6 months was nearly two-fold higher in the mildly frail, three-fold higher in the moderately frail, and nine-fold higher in the severely frail participants. Conclusions: This study demonstrated a very high prevalence of frailty in older patients with end-stage renal disease and dialysis and the significant impact of frailty severity on mortality. Healthcare providers should consider incorporating frailty screening into routine care for older patients with end-stage renal disease and dialysis. |
| first_indexed | 2024-03-10T22:53:36Z |
| format | Article |
| id | doaj.art-cb1efbe2e4554e9cb594e9bef65cc768 |
| institution | Directory Open Access Journal |
| issn | 2673-4540 |
| language | English |
| last_indexed | 2024-03-10T22:53:36Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diabetology |
| spelling | doaj.art-cb1efbe2e4554e9cb594e9bef65cc7682023-11-19T10:12:30ZengMDPI AGDiabetology2673-45402023-08-014331232210.3390/diabetology4030027Frailty in Older Patients with End-Stage Renal Disease and Undergoing Chronic Haemodialysis in VietnamTan Van Nguyen0Thu Thi Xuan Pham1Mason Jenner Burns2Tu Ngoc Nguyen3Department of Geriatrics & Gerontology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, VietnamDepartment of Geriatrics & Gerontology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, VietnamWestmead Applied Research Centre, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, AustraliaWestmead Applied Research Centre, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, AustraliaBackground: There is limited evidence on the association between chronic kidney disease (CKD) and frailty in older people in Vietnam. This study aimed to investigate the prevalence of frailty and its impact on mortality in older patients with end-stage renal disease. Method: This is a prospective, observational study performed at two large Dialysis Centres in Vietnam from November 2020 to June 2021. Consecutive older patients diagnosed with end-stage renal disease and on haemodialysis were recruited. Participants’ frailty status was defined by the Clinical Frailty Scale (CFS). The study outcome was all-cause mortality at the sixth month. Results: A total of 175 participants were recruited (mean age 72.4 years, 58.9% female). Using the cut point of CFS ≥ 4, 87.4% of the participants were frail. Mortality at the sixth month was 14.9%, 31.9% in participants with CFS ≥ 7, 12.8% in participants with CFS = 6, 7.5% in participants with CFS from 4 to 5, and 4.5% in participants with CFS ≤ 3 (<i>p</i> = 0.001). Cox regression analysis showed that, compared with the non-frail participants, the probability of death over 6 months was nearly two-fold higher in the mildly frail, three-fold higher in the moderately frail, and nine-fold higher in the severely frail participants. Conclusions: This study demonstrated a very high prevalence of frailty in older patients with end-stage renal disease and dialysis and the significant impact of frailty severity on mortality. Healthcare providers should consider incorporating frailty screening into routine care for older patients with end-stage renal disease and dialysis.https://www.mdpi.com/2673-4540/4/3/27chronic kidney diseaseend-stage renal diseasedialysisdiabetesfrailtyelderly |
| spellingShingle | Tan Van Nguyen Thu Thi Xuan Pham Mason Jenner Burns Tu Ngoc Nguyen Frailty in Older Patients with End-Stage Renal Disease and Undergoing Chronic Haemodialysis in Vietnam Diabetology chronic kidney disease end-stage renal disease dialysis diabetes frailty elderly |
| title | Frailty in Older Patients with End-Stage Renal Disease and Undergoing Chronic Haemodialysis in Vietnam |
| title_full | Frailty in Older Patients with End-Stage Renal Disease and Undergoing Chronic Haemodialysis in Vietnam |
| title_fullStr | Frailty in Older Patients with End-Stage Renal Disease and Undergoing Chronic Haemodialysis in Vietnam |
| title_full_unstemmed | Frailty in Older Patients with End-Stage Renal Disease and Undergoing Chronic Haemodialysis in Vietnam |
| title_short | Frailty in Older Patients with End-Stage Renal Disease and Undergoing Chronic Haemodialysis in Vietnam |
| title_sort | frailty in older patients with end stage renal disease and undergoing chronic haemodialysis in vietnam |
| topic | chronic kidney disease end-stage renal disease dialysis diabetes frailty elderly |
| url | https://www.mdpi.com/2673-4540/4/3/27 |
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