TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.

Mutations in or dys-regulation of the TDP-43 gene have been associated with TDP-43 proteinopathy, a spectrum of neurodegenerative diseases including Frontotemporal Lobar Degeneration (FTLD) and Amyotrophic Lateral Sclerosis (ALS). The underlying molecular and cellular defects, however, remain unclea...

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Bibliographic Details
Main Authors:	Peng Wang, Jianwen Deng, Jie Dong, Jianghong Liu, Eileen H Bigio, Marsel Mesulam, Tao Wang, Lei Sun, Li Wang, Alan Yueh-Luen Lee, Warren A McGee, Xiaoping Chen, Kazuo Fushimi, Li Zhu, Jane Y Wu
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2019-05-01
Series:	PLoS Genetics
Online Access:	https://doi.org/10.1371/journal.pgen.1007947

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