Calcium in Vascular Smooth Muscle Cell Elasticity and Adhesion: Novel Insights Into the Mechanism of Action
Vascular smooth muscle cells (VSMCs) are the predominant cell type in the arterial wall. These cells play a critical role in maintaining vascular homeostasis including vasoconstriction and vasodilatation through active contraction and relaxation. Dysregulation of VSMC function alters the response of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.00852/full |
| _version_ | 1811214034725240832 |
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| author | Yi Zhu Yi Zhu Jing Qu Jing Qu Li He Feng Zhang Feng Zhang Zijing Zhou Zijing Zhou Shanzhong Yang Yong Zhou |
| author_facet | Yi Zhu Yi Zhu Jing Qu Jing Qu Li He Feng Zhang Feng Zhang Zijing Zhou Zijing Zhou Shanzhong Yang Yong Zhou |
| author_sort | Yi Zhu |
| collection | DOAJ |
| description | Vascular smooth muscle cells (VSMCs) are the predominant cell type in the arterial wall. These cells play a critical role in maintaining vascular homeostasis including vasoconstriction and vasodilatation through active contraction and relaxation. Dysregulation of VSMC function alters the response of blood vessels to mechanical stress, contributing to the pathogenesis of vascular diseases, particularly atherosclerosis and hypertension. The stiffness of VSMCs is a major regulator of vascular function. Previous studies suggest that intracellular Ca2+ controls the stiffness of VSMCs by a mechanism involving myosin contractile apparatus. More recent studies highlight important functions of cytoskeletal α-smooth muscle actin (α-SMA), α5β1 integrin, and integrin-mediated cell-extracellular matrix (ECM) interactions in Ca2+-dependent regulation of VSMC stiffness and adhesion to the ECM, providing novel insights into the mechanism of calcium action. |
| first_indexed | 2024-04-12T05:56:26Z |
| format | Article |
| id | doaj.art-cb1fefcd14ff43869a79d053ad8f42bd |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T05:56:26Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-cb1fefcd14ff43869a79d053ad8f42bd2022-12-22T03:45:08ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-08-011010.3389/fphys.2019.00852458924Calcium in Vascular Smooth Muscle Cell Elasticity and Adhesion: Novel Insights Into the Mechanism of ActionYi Zhu0Yi Zhu1Jing Qu2Jing Qu3Li He4Feng Zhang5Feng Zhang6Zijing Zhou7Zijing Zhou8Shanzhong Yang9Yong Zhou10Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United StatesDalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, MO, United StatesDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United StatesDepartment of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United StatesDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United StatesDepartment of Ophthalmology, The Second Xiangya Hospital, Central-South University, Changsha, ChinaDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United StatesDepartment of Respiratory Medicine, The Second Xiangya Hospital, Central-South University, Changsha, ChinaDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United StatesDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama-Birmingham, Birmingham, AL, United StatesVascular smooth muscle cells (VSMCs) are the predominant cell type in the arterial wall. These cells play a critical role in maintaining vascular homeostasis including vasoconstriction and vasodilatation through active contraction and relaxation. Dysregulation of VSMC function alters the response of blood vessels to mechanical stress, contributing to the pathogenesis of vascular diseases, particularly atherosclerosis and hypertension. The stiffness of VSMCs is a major regulator of vascular function. Previous studies suggest that intracellular Ca2+ controls the stiffness of VSMCs by a mechanism involving myosin contractile apparatus. More recent studies highlight important functions of cytoskeletal α-smooth muscle actin (α-SMA), α5β1 integrin, and integrin-mediated cell-extracellular matrix (ECM) interactions in Ca2+-dependent regulation of VSMC stiffness and adhesion to the ECM, providing novel insights into the mechanism of calcium action.https://www.frontiersin.org/article/10.3389/fphys.2019.00852/fullvascular smooth muscle cellcalciumelasticityadhesionextracellular matrix-integrin-cytoskeletal axis |
| spellingShingle | Yi Zhu Yi Zhu Jing Qu Jing Qu Li He Feng Zhang Feng Zhang Zijing Zhou Zijing Zhou Shanzhong Yang Yong Zhou Calcium in Vascular Smooth Muscle Cell Elasticity and Adhesion: Novel Insights Into the Mechanism of Action Frontiers in Physiology vascular smooth muscle cell calcium elasticity adhesion extracellular matrix-integrin-cytoskeletal axis |
| title | Calcium in Vascular Smooth Muscle Cell Elasticity and Adhesion: Novel Insights Into the Mechanism of Action |
| title_full | Calcium in Vascular Smooth Muscle Cell Elasticity and Adhesion: Novel Insights Into the Mechanism of Action |
| title_fullStr | Calcium in Vascular Smooth Muscle Cell Elasticity and Adhesion: Novel Insights Into the Mechanism of Action |
| title_full_unstemmed | Calcium in Vascular Smooth Muscle Cell Elasticity and Adhesion: Novel Insights Into the Mechanism of Action |
| title_short | Calcium in Vascular Smooth Muscle Cell Elasticity and Adhesion: Novel Insights Into the Mechanism of Action |
| title_sort | calcium in vascular smooth muscle cell elasticity and adhesion novel insights into the mechanism of action |
| topic | vascular smooth muscle cell calcium elasticity adhesion extracellular matrix-integrin-cytoskeletal axis |
| url | https://www.frontiersin.org/article/10.3389/fphys.2019.00852/full |
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