Cockroach exposure and its allergy sensitization in asthma patients
Asthma is a heterogeneous disease with distinct phenotypes. Serum tIgE, SSIgE and SPT are the methods of evaluating allergen sensitization. The present study evaluates the exposure and sensitization to cockroach (Periplaneta americana) antigens in asthma patients in a metropolitan city of India. The...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2021-05-01
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| Series: | Monaldi Archives for Chest Disease |
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| Online Access: | https://www.monaldi-archives.org/index.php/macd/article/view/1685 |
| _version_ | 1818891499271618560 |
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| author | Manoj Kumar Rajesh Kumar Gupta Raj Kumar Sonam Spalgais Anil Kumar Mavi Kamal Singh |
| author_facet | Manoj Kumar Rajesh Kumar Gupta Raj Kumar Sonam Spalgais Anil Kumar Mavi Kamal Singh |
| author_sort | Manoj Kumar |
| collection | DOAJ |
| description | Asthma is a heterogeneous disease with distinct phenotypes. Serum tIgE, SSIgE and SPT are the methods of evaluating allergen sensitization. The present study evaluates the exposure and sensitization to cockroach (Periplaneta americana) antigens in asthma patients in a metropolitan city of India. The study enrolled 200 consecutive bronchial asthma patients, diagnosed as per GINA guidelines. As per history of exposure to cockroaches, the patients are divided in two groups as exposed and non-exposed asthmatic. All the enrolled subjects underwent SPT against common aeroallergens including cockroach, spirometry and estimation of tIgE level and SSIgE against cockroach. Out of 200 asthma patients, a total of 114 (57%) asthmatic were found SPT positive against one of the common aeroallergens, of which 68 (34%) showed SPT sensitivity against cockroach. A total of 103 (51.5%) patients were found exposed to cockroaches. In the cockroach exposed group, the mean serum tIgE was found significantly higher than the non-exposed group (569.31±224.64 vs 479.29±237 IU/ml; p=0.007). The mean SSIgE against cockroach in exposed groups was found not significant than non-expose group (4.87±11.19 vs 4.11±8.39 KUA/L; p=0.589). The mean tIgE was also not significant in atopic compared to non-atopic asthmatic (553.25±218.12 IU/ml vs 489.1±251.16 IU/ml; p=0.056). The mean SSIgE against cockroach was 5.66±10.45 KUA/L for atopic and 2.96±8.98 KUA/L for non-atopic (p=0.054). The airway obstruction was almost the same in both groups. Asthmatic patients who were exposed to cockroach and atopic had high tIgE, SSIgE levels and SPT positivity against cockroach antigen compared to non-exposed patients. |
| first_indexed | 2024-12-19T17:41:47Z |
| format | Article |
| id | doaj.art-cb20af91266e45e9af7056ccb9b49f3e |
| institution | Directory Open Access Journal |
| issn | 1122-0643 2532-5264 |
| language | English |
| last_indexed | 2024-12-19T17:41:47Z |
| publishDate | 2021-05-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Monaldi Archives for Chest Disease |
| spelling | doaj.art-cb20af91266e45e9af7056ccb9b49f3e2022-12-21T20:12:11ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642021-05-0110.4081/monaldi.2021.1685Cockroach exposure and its allergy sensitization in asthma patientsManoj Kumar0Rajesh Kumar Gupta1Raj Kumar2Sonam Spalgais3Anil Kumar Mavi4Kamal Singh5Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of DelhiDepartment of Applied Chemistry, School of Vocational Studies and Applied Sciences, Gautam Buddha University, Greater Noida U.PDepartment of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of DelhiDepartment of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of DelhiDepartment of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of DelhiDepartment of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of DelhiAsthma is a heterogeneous disease with distinct phenotypes. Serum tIgE, SSIgE and SPT are the methods of evaluating allergen sensitization. The present study evaluates the exposure and sensitization to cockroach (Periplaneta americana) antigens in asthma patients in a metropolitan city of India. The study enrolled 200 consecutive bronchial asthma patients, diagnosed as per GINA guidelines. As per history of exposure to cockroaches, the patients are divided in two groups as exposed and non-exposed asthmatic. All the enrolled subjects underwent SPT against common aeroallergens including cockroach, spirometry and estimation of tIgE level and SSIgE against cockroach. Out of 200 asthma patients, a total of 114 (57%) asthmatic were found SPT positive against one of the common aeroallergens, of which 68 (34%) showed SPT sensitivity against cockroach. A total of 103 (51.5%) patients were found exposed to cockroaches. In the cockroach exposed group, the mean serum tIgE was found significantly higher than the non-exposed group (569.31±224.64 vs 479.29±237 IU/ml; p=0.007). The mean SSIgE against cockroach in exposed groups was found not significant than non-expose group (4.87±11.19 vs 4.11±8.39 KUA/L; p=0.589). The mean tIgE was also not significant in atopic compared to non-atopic asthmatic (553.25±218.12 IU/ml vs 489.1±251.16 IU/ml; p=0.056). The mean SSIgE against cockroach was 5.66±10.45 KUA/L for atopic and 2.96±8.98 KUA/L for non-atopic (p=0.054). The airway obstruction was almost the same in both groups. Asthmatic patients who were exposed to cockroach and atopic had high tIgE, SSIgE levels and SPT positivity against cockroach antigen compared to non-exposed patients.https://www.monaldi-archives.org/index.php/macd/article/view/1685Cockroachasthmaskin prick testspecific IgEtotal IgE |
| spellingShingle | Manoj Kumar Rajesh Kumar Gupta Raj Kumar Sonam Spalgais Anil Kumar Mavi Kamal Singh Cockroach exposure and its allergy sensitization in asthma patients Monaldi Archives for Chest Disease Cockroach asthma skin prick test specific IgE total IgE |
| title | Cockroach exposure and its allergy sensitization in asthma patients |
| title_full | Cockroach exposure and its allergy sensitization in asthma patients |
| title_fullStr | Cockroach exposure and its allergy sensitization in asthma patients |
| title_full_unstemmed | Cockroach exposure and its allergy sensitization in asthma patients |
| title_short | Cockroach exposure and its allergy sensitization in asthma patients |
| title_sort | cockroach exposure and its allergy sensitization in asthma patients |
| topic | Cockroach asthma skin prick test specific IgE total IgE |
| url | https://www.monaldi-archives.org/index.php/macd/article/view/1685 |
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