The Association Between the Composite Dietary Antioxidant Index and Frailty Symptoms: Mediating Effects of Oxidative Stress
Yue Wu,1 Siqi Cheng,1 Shaoyuan Lei,2 Dongxiao Li,3 Zhongzhong Li,4 Yansu Guo1,2,5 1Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Evidence-Based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, Peop...
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Dove Medical Press
2024-02-01
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| Series: | Clinical Interventions in Aging |
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| Online Access: | https://www.dovepress.com/the-association-between-the-composite-dietary-antioxidant-index-and-fr-peer-reviewed-fulltext-article-CIA |
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| author | Wu Y Cheng S Lei S Li D Li Z Guo Y |
| author_facet | Wu Y Cheng S Lei S Li D Li Z Guo Y |
| author_sort | Wu Y |
| collection | DOAJ |
| description | Yue Wu,1 Siqi Cheng,1 Shaoyuan Lei,2 Dongxiao Li,3 Zhongzhong Li,4 Yansu Guo1,2,5 1Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Evidence-Based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Neurology, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, People’s Republic of China; 4Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 5Beijing Municipal Geriatric Medical Research Center, Beijing, People’s Republic of ChinaCorrespondence: Yansu Guo, Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, People’s Republic of China, Email gys188@163.comBackground: There is growing evidence that an antioxidant diet is a protective factor against frailty. However, few studies have examined the effect of comprehensive dietary antioxidants on frailty symptoms. The aim of this study was to examine the relationships between the composite dietary antioxidant index (CDAI) and frailty and the underlying mechanisms involved.Methods: Based on the National Health and Nutrition Survey (NHANES) 2003– 2018, this study included 11,277 older persons aged ≥ 60 years. In this study, frailty was defined as having a total score > 0.21 on the 49-item frailty index. Six dietary antioxidants were selected for use in calculating the CDAI. A weighted multiple logistic regression model with subgroup analysis and restricted cubic splines (RCSs) were used to examine the association between the CDAI and frailty. To examine the role of oxidative stress, mediation analyses were also conducted.Results: The association between the CDAI score and frailty risk was significant according to the multivariate model. Compared with participants in tertile 1, participants in both tertile 2 and tertile 3 had lower odds of developing frailty symptoms (OR=0.86; 95% CI=0.75– 0.97; P=0.02; and OR=0.81; 95% CI=0.70– 0.93; P=0.003). According to the subgroup analyses, the differences in interactions were not statistically significant. There was also a potential nonlinear relationship between the CDAI score and frailty risk. The serum albumin concentration and uric acid concentration had significant mediating effects on the association between the CDAI score and frailty index, with 19.25% (P=0.002) and 21.26% (P < 0.001) of the total, respectively.Conclusion: Frailty is negatively associated with the CDAI score, which may be partially mediated by oxidative stress.Keywords: frailty, CDAI, NHANES, elderly adults |
| first_indexed | 2024-03-08T06:08:55Z |
| format | Article |
| id | doaj.art-cb218cbfc21d48d28c8d06e6a144b8be |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-03-08T06:08:55Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-cb218cbfc21d48d28c8d06e6a144b8be2024-02-04T17:43:33ZengDove Medical PressClinical Interventions in Aging1178-19982024-02-01Volume 1916317390204The Association Between the Composite Dietary Antioxidant Index and Frailty Symptoms: Mediating Effects of Oxidative StressWu YCheng SLei SLi DLi ZGuo YYue Wu,1 Siqi Cheng,1 Shaoyuan Lei,2 Dongxiao Li,3 Zhongzhong Li,4 Yansu Guo1,2,5 1Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Evidence-Based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Neurology, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, People’s Republic of China; 4Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 5Beijing Municipal Geriatric Medical Research Center, Beijing, People’s Republic of ChinaCorrespondence: Yansu Guo, Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Changchun Street 45, Beijing, People’s Republic of China, Email gys188@163.comBackground: There is growing evidence that an antioxidant diet is a protective factor against frailty. However, few studies have examined the effect of comprehensive dietary antioxidants on frailty symptoms. The aim of this study was to examine the relationships between the composite dietary antioxidant index (CDAI) and frailty and the underlying mechanisms involved.Methods: Based on the National Health and Nutrition Survey (NHANES) 2003– 2018, this study included 11,277 older persons aged ≥ 60 years. In this study, frailty was defined as having a total score > 0.21 on the 49-item frailty index. Six dietary antioxidants were selected for use in calculating the CDAI. A weighted multiple logistic regression model with subgroup analysis and restricted cubic splines (RCSs) were used to examine the association between the CDAI and frailty. To examine the role of oxidative stress, mediation analyses were also conducted.Results: The association between the CDAI score and frailty risk was significant according to the multivariate model. Compared with participants in tertile 1, participants in both tertile 2 and tertile 3 had lower odds of developing frailty symptoms (OR=0.86; 95% CI=0.75– 0.97; P=0.02; and OR=0.81; 95% CI=0.70– 0.93; P=0.003). According to the subgroup analyses, the differences in interactions were not statistically significant. There was also a potential nonlinear relationship between the CDAI score and frailty risk. The serum albumin concentration and uric acid concentration had significant mediating effects on the association between the CDAI score and frailty index, with 19.25% (P=0.002) and 21.26% (P < 0.001) of the total, respectively.Conclusion: Frailty is negatively associated with the CDAI score, which may be partially mediated by oxidative stress.Keywords: frailty, CDAI, NHANES, elderly adultshttps://www.dovepress.com/the-association-between-the-composite-dietary-antioxidant-index-and-fr-peer-reviewed-fulltext-article-CIAfrailtycdainhaneselderly adults |
| spellingShingle | Wu Y Cheng S Lei S Li D Li Z Guo Y The Association Between the Composite Dietary Antioxidant Index and Frailty Symptoms: Mediating Effects of Oxidative Stress Clinical Interventions in Aging frailty cdai nhanes elderly adults |
| title | The Association Between the Composite Dietary Antioxidant Index and Frailty Symptoms: Mediating Effects of Oxidative Stress |
| title_full | The Association Between the Composite Dietary Antioxidant Index and Frailty Symptoms: Mediating Effects of Oxidative Stress |
| title_fullStr | The Association Between the Composite Dietary Antioxidant Index and Frailty Symptoms: Mediating Effects of Oxidative Stress |
| title_full_unstemmed | The Association Between the Composite Dietary Antioxidant Index and Frailty Symptoms: Mediating Effects of Oxidative Stress |
| title_short | The Association Between the Composite Dietary Antioxidant Index and Frailty Symptoms: Mediating Effects of Oxidative Stress |
| title_sort | association between the composite dietary antioxidant index and frailty symptoms mediating effects of oxidative stress |
| topic | frailty cdai nhanes elderly adults |
| url | https://www.dovepress.com/the-association-between-the-composite-dietary-antioxidant-index-and-fr-peer-reviewed-fulltext-article-CIA |
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