Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor
Abstract Incomplete tumor resection is the direct cause of the tumor recurrence and metastasis after surgery. Intraoperative accurate detection and elimination of microscopic residual cancer improve surgery outcomes. In this study, a powerful D1–π–A–D2–R type phototheranostic based on aggregation-in...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01325-9 |
| _version_ | 1811305724588851200 |
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| author | Qiaojun Qu Zeyu Zhang Xiaoyong Guo Junying Yang Caiguang Cao Changjian Li Hui Zhang Pengfei Xu Zhenhua Hu Jie Tian |
| author_facet | Qiaojun Qu Zeyu Zhang Xiaoyong Guo Junying Yang Caiguang Cao Changjian Li Hui Zhang Pengfei Xu Zhenhua Hu Jie Tian |
| author_sort | Qiaojun Qu |
| collection | DOAJ |
| description | Abstract Incomplete tumor resection is the direct cause of the tumor recurrence and metastasis after surgery. Intraoperative accurate detection and elimination of microscopic residual cancer improve surgery outcomes. In this study, a powerful D1–π–A–D2–R type phototheranostic based on aggregation-induced emission (AIE)-active the second near-infrared window (NIR-II) fluorophore is designed and constructed. The prepared theranostic agent, A1 nanoparticles (NPs), simultaneously shows high absolute quantum yield (1.23%), excellent photothermal conversion efficiency (55.3%), high molar absorption coefficient and moderate singlet oxygen generation performance. In vivo experiments indicate that NIR-II fluorescence imaging of A1 NPs precisely detect microscopic residual tumor (2 mm in diameter) in the tumor bed and metastatic lymph nodes. More notably, a novel integrated strategy that achieves complete tumor eradication (no local recurrence and metastasis after surgery) is proposed. In summary, A1 NPs possess superior imaging and treatment performance, and can detect and eliminate residual tumor lesions intraoperatively. This work provides a promising technique for future clinical applications achieving improved surgical outcomes. Graphic Abstract |
| first_indexed | 2024-04-13T08:31:37Z |
| format | Article |
| id | doaj.art-cb2217be52eb4a4788b67b3dd26e2506 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-13T08:31:37Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-cb2217be52eb4a4788b67b3dd26e25062022-12-22T02:54:15ZengBMCJournal of Nanobiotechnology1477-31552022-03-0120111510.1186/s12951-022-01325-9Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumorQiaojun Qu0Zeyu Zhang1Xiaoyong Guo2Junying Yang3Caiguang Cao4Changjian Li5Hui Zhang6Pengfei Xu7Zhenhua Hu8Jie Tian9College of Medical Imaging, Shanxi Medical UniversityCAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of SciencesCAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of SciencesDepartment of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical UniversityCAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of SciencesBeijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine and Engineering, Beihang UniversityDepartment of Radiology, First Hospital of Shanxi Medical UniversityInstitute of Clinical Pharmacy & Pharmacology, Jining First People’s Hospital, Jining Medical UniversityCAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, The State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of SciencesCollege of Medical Imaging, Shanxi Medical UniversityAbstract Incomplete tumor resection is the direct cause of the tumor recurrence and metastasis after surgery. Intraoperative accurate detection and elimination of microscopic residual cancer improve surgery outcomes. In this study, a powerful D1–π–A–D2–R type phototheranostic based on aggregation-induced emission (AIE)-active the second near-infrared window (NIR-II) fluorophore is designed and constructed. The prepared theranostic agent, A1 nanoparticles (NPs), simultaneously shows high absolute quantum yield (1.23%), excellent photothermal conversion efficiency (55.3%), high molar absorption coefficient and moderate singlet oxygen generation performance. In vivo experiments indicate that NIR-II fluorescence imaging of A1 NPs precisely detect microscopic residual tumor (2 mm in diameter) in the tumor bed and metastatic lymph nodes. More notably, a novel integrated strategy that achieves complete tumor eradication (no local recurrence and metastasis after surgery) is proposed. In summary, A1 NPs possess superior imaging and treatment performance, and can detect and eliminate residual tumor lesions intraoperatively. This work provides a promising technique for future clinical applications achieving improved surgical outcomes. Graphic Abstracthttps://doi.org/10.1186/s12951-022-01325-9Aggregation-induced emissionNIR-II imagingPhototherapyPhototheranosticResidual tumor |
| spellingShingle | Qiaojun Qu Zeyu Zhang Xiaoyong Guo Junying Yang Caiguang Cao Changjian Li Hui Zhang Pengfei Xu Zhenhua Hu Jie Tian Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor Journal of Nanobiotechnology Aggregation-induced emission NIR-II imaging Phototherapy Phototheranostic Residual tumor |
| title | Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor |
| title_full | Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor |
| title_fullStr | Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor |
| title_full_unstemmed | Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor |
| title_short | Novel multifunctional NIR-II aggregation-induced emission nanoparticles-assisted intraoperative identification and elimination of residual tumor |
| title_sort | novel multifunctional nir ii aggregation induced emission nanoparticles assisted intraoperative identification and elimination of residual tumor |
| topic | Aggregation-induced emission NIR-II imaging Phototherapy Phototheranostic Residual tumor |
| url | https://doi.org/10.1186/s12951-022-01325-9 |
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