Backbone-independent NMR resonance assignments of methyl probes in large proteins
Here, the authors present Methyl Assignments Using Satisfiability (MAUS), a method for the assignment of methyl groups using raw NOE data. They use eight proteins in the 10–45 kDa size range as test cases and show that MAUS yields 100% accurate assignments at high completeness levels.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-20984-0 |
| _version_ | 1818399495302414336 |
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| author | Santrupti Nerli Viviane S. De Paula Andrew C. McShan Nikolaos G. Sgourakis |
| author_facet | Santrupti Nerli Viviane S. De Paula Andrew C. McShan Nikolaos G. Sgourakis |
| author_sort | Santrupti Nerli |
| collection | DOAJ |
| description | Here, the authors present Methyl Assignments Using Satisfiability (MAUS), a method for the assignment of methyl groups using raw NOE data. They use eight proteins in the 10–45 kDa size range as test cases and show that MAUS yields 100% accurate assignments at high completeness levels. |
| first_indexed | 2024-12-14T07:21:35Z |
| format | Article |
| id | doaj.art-cb22eaddf85f4c9698cd9093fadb2f6b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:21:35Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cb22eaddf85f4c9698cd9093fadb2f6b2022-12-21T23:11:37ZengNature PortfolioNature Communications2041-17232021-01-0112111310.1038/s41467-021-20984-0Backbone-independent NMR resonance assignments of methyl probes in large proteinsSantrupti Nerli0Viviane S. De Paula1Andrew C. McShan2Nikolaos G. Sgourakis3Department of Biomolecular Engineering, University of CaliforniaCenter for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia and Department of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaCenter for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia and Department of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaCenter for Computational and Genomic Medicine, Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia and Department of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaHere, the authors present Methyl Assignments Using Satisfiability (MAUS), a method for the assignment of methyl groups using raw NOE data. They use eight proteins in the 10–45 kDa size range as test cases and show that MAUS yields 100% accurate assignments at high completeness levels.https://doi.org/10.1038/s41467-021-20984-0 |
| spellingShingle | Santrupti Nerli Viviane S. De Paula Andrew C. McShan Nikolaos G. Sgourakis Backbone-independent NMR resonance assignments of methyl probes in large proteins Nature Communications |
| title | Backbone-independent NMR resonance assignments of methyl probes in large proteins |
| title_full | Backbone-independent NMR resonance assignments of methyl probes in large proteins |
| title_fullStr | Backbone-independent NMR resonance assignments of methyl probes in large proteins |
| title_full_unstemmed | Backbone-independent NMR resonance assignments of methyl probes in large proteins |
| title_short | Backbone-independent NMR resonance assignments of methyl probes in large proteins |
| title_sort | backbone independent nmr resonance assignments of methyl probes in large proteins |
| url | https://doi.org/10.1038/s41467-021-20984-0 |
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