Garlic (<i>Allium sativum</i> L.) Bioactives and Its Role in Alleviating Oral Pathologies
Garlic (<i>Allium sativa</i> L.) is a bulbous flowering plant belongs to the family of Amaryllidaceae and is a predominant horticultural crop originating from central Asia. Garlic and its products are chiefly used for culinary and therapeutic purposes in many countries. Bulbs of raw garl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/11/1847 |
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| author | Minnu Sasi Sandeep Kumar Manoj Kumar Sandhya Thapa Uma Prajapati Yamini Tak Sushil Changan Vivek Saurabh Shweta Kumari Ashok Kumar Muzaffar Hasan Deepak Chandran Radha Sneh Punia Bangar Sangram Dhumal Marisennayya Senapathy Anitha Thiyagarajan Ahmad Alhariri Abhijit Dey Surinder Singh Suraj Prakash Ravi Pandiselvam Mohamed Mekhemar |
| author_facet | Minnu Sasi Sandeep Kumar Manoj Kumar Sandhya Thapa Uma Prajapati Yamini Tak Sushil Changan Vivek Saurabh Shweta Kumari Ashok Kumar Muzaffar Hasan Deepak Chandran Radha Sneh Punia Bangar Sangram Dhumal Marisennayya Senapathy Anitha Thiyagarajan Ahmad Alhariri Abhijit Dey Surinder Singh Suraj Prakash Ravi Pandiselvam Mohamed Mekhemar |
| author_sort | Minnu Sasi |
| collection | DOAJ |
| description | Garlic (<i>Allium sativa</i> L.) is a bulbous flowering plant belongs to the family of Amaryllidaceae and is a predominant horticultural crop originating from central Asia. Garlic and its products are chiefly used for culinary and therapeutic purposes in many countries. Bulbs of raw garlic have been investigated for their role in oral health, which are ascribed to a myriad of biologically active compounds such as alliin, allicin, methiin, S-allylcysteine (SAC), diallyl sulfide (DAS), S-ally-mercapto cysteine (SAMC), diallyl disulphide (DADS), diallyl trisulfide (DATS) and methyl allyl disulphide. A systematic review was conducted following the PRISMA statement. Scopus, PubMed, Clinicaltrials.gov, and Science direct databases were searched between 12 April 2021 to 4 September 2021. A total of 148 studies were included and the qualitative synthesis phytochemical profile of GE, biological activities, therapeutic applications of garlic extract (GE) in oral health care system, and its mechanism of action in curing various oral pathologies have been discussed. Furthermore, the safety of incorporation of GE as food supplements is also critically discussed. To conclude, GE could conceivably make a treatment recourse for patients suffering from diverse oral diseases. |
| first_indexed | 2024-03-10T05:45:34Z |
| format | Article |
| id | doaj.art-cb23d097794441309f92fca356bbbd15 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T05:45:34Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-cb23d097794441309f92fca356bbbd152023-11-22T22:14:35ZengMDPI AGAntioxidants2076-39212021-11-011011184710.3390/antiox10111847Garlic (<i>Allium sativum</i> L.) Bioactives and Its Role in Alleviating Oral PathologiesMinnu Sasi0Sandeep Kumar1Manoj Kumar2Sandhya Thapa3Uma Prajapati4Yamini Tak5Sushil Changan6Vivek Saurabh7Shweta Kumari8Ashok Kumar9Muzaffar Hasan10Deepak Chandran11Radha12Sneh Punia Bangar13Sangram Dhumal14Marisennayya Senapathy15Anitha Thiyagarajan16Ahmad Alhariri17Abhijit Dey18Surinder Singh19Suraj Prakash20Ravi Pandiselvam21Mohamed Mekhemar22Division of Biochemistry, ICAR—Indian Agricultural Research Institute, New Delhi 110012, IndiaQuality and Productivity Improvement Division, ICAR—Indian Institute of Natural Resins and Gums, Ranchi 834010, IndiaChemical and Biochemical Processing Division, ICAR—Central Institute for Research on Cotton Technology, Mumbai 400019, IndiaDepartment of Horticulture, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi 221005, IndiaDivision of Food Science and Postharvest Technology, ICAR—Indian Agricultural Research Institute, New Delhi 110012, IndiaDepartment of Biochemistry, Agriculture University, Kota 324001, IndiaDivision of Crop Physiology, Biochemistry and Post-Harvest Technology, ICAR—Central Potato Research Institute, Shimla 171001, IndiaDivision of Food Science and Postharvest Technology, ICAR—Indian Agricultural Research Institute, New Delhi 110012, IndiaCentre for Agricultural Bioinformatics, ICAR—Indian Agricultural Statistics Research Institute (IASRI), Library Avenue, New Delhi 110012, IndiaPost-Harvest Technology and Biochemistry, ICAR—Directorate of Onion and Garlic Research, Pune 410505, IndiaAgro Produce Processing Division, ICAR—Central Institute of Agricultural Engineering, Bhopal 462038, IndiaDepartment of Veterinary Sciences and Animal Husbandry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore 642109, IndiaSchool of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, IndiaDepartment of Food, Nutrition, & Packaging Sciences, Clemson University, Clemson, SC 29634, USADivision of Horticulture, RCSM College of Agriculture, Kolhapur 416004, IndiaDepartment of Rural Development and Agricultural Extension, College of Agriculture, Wolaita Sodo University, Wolaita Sodo 138, SNNPR, EthiopiaDepartment of Postharvest Technology, Horticultural College and Research Institute, Periyakulam 625604, IndiaFaculty of Agriculture, Damascus University, Damascus 30621, SyriaDepartment of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, IndiaDr. S. S. Bhatnagar University Institute of Chemical Engineering and Technology, Panjab University, Chandigarh 160014, IndiaSchool of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, IndiaDivision of Physiology, Biochemistry and Post-Harvest Technology, ICAR—Central Plantation Crops Research Institute (CPCRI), Kasaragod 671124, IndiaClinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian-Albrecht’s University, 24105 Kiel, GermanyGarlic (<i>Allium sativa</i> L.) is a bulbous flowering plant belongs to the family of Amaryllidaceae and is a predominant horticultural crop originating from central Asia. Garlic and its products are chiefly used for culinary and therapeutic purposes in many countries. Bulbs of raw garlic have been investigated for their role in oral health, which are ascribed to a myriad of biologically active compounds such as alliin, allicin, methiin, S-allylcysteine (SAC), diallyl sulfide (DAS), S-ally-mercapto cysteine (SAMC), diallyl disulphide (DADS), diallyl trisulfide (DATS) and methyl allyl disulphide. A systematic review was conducted following the PRISMA statement. Scopus, PubMed, Clinicaltrials.gov, and Science direct databases were searched between 12 April 2021 to 4 September 2021. A total of 148 studies were included and the qualitative synthesis phytochemical profile of GE, biological activities, therapeutic applications of garlic extract (GE) in oral health care system, and its mechanism of action in curing various oral pathologies have been discussed. Furthermore, the safety of incorporation of GE as food supplements is also critically discussed. To conclude, GE could conceivably make a treatment recourse for patients suffering from diverse oral diseases.https://www.mdpi.com/2076-3921/10/11/1847phytochemicalsgarlicbioactivitiesantioxidantoral careoral health |
| spellingShingle | Minnu Sasi Sandeep Kumar Manoj Kumar Sandhya Thapa Uma Prajapati Yamini Tak Sushil Changan Vivek Saurabh Shweta Kumari Ashok Kumar Muzaffar Hasan Deepak Chandran Radha Sneh Punia Bangar Sangram Dhumal Marisennayya Senapathy Anitha Thiyagarajan Ahmad Alhariri Abhijit Dey Surinder Singh Suraj Prakash Ravi Pandiselvam Mohamed Mekhemar Garlic (<i>Allium sativum</i> L.) Bioactives and Its Role in Alleviating Oral Pathologies Antioxidants phytochemicals garlic bioactivities antioxidant oral care oral health |
| title | Garlic (<i>Allium sativum</i> L.) Bioactives and Its Role in Alleviating Oral Pathologies |
| title_full | Garlic (<i>Allium sativum</i> L.) Bioactives and Its Role in Alleviating Oral Pathologies |
| title_fullStr | Garlic (<i>Allium sativum</i> L.) Bioactives and Its Role in Alleviating Oral Pathologies |
| title_full_unstemmed | Garlic (<i>Allium sativum</i> L.) Bioactives and Its Role in Alleviating Oral Pathologies |
| title_short | Garlic (<i>Allium sativum</i> L.) Bioactives and Its Role in Alleviating Oral Pathologies |
| title_sort | garlic i allium sativum i l bioactives and its role in alleviating oral pathologies |
| topic | phytochemicals garlic bioactivities antioxidant oral care oral health |
| url | https://www.mdpi.com/2076-3921/10/11/1847 |
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