The level of TNF soluble receptor type 1 in patients with systemic sclerosis
Aim. To study content and clinical correlations ofsTNF-RI in patients with systemic sclerosis (SS). Material and methods. Thirty nine SS patients were examined with enzyme immunoassay for serum levels of sTNF-RIand soluble adhesion molecules (sSAM) sVSAM-1, sISAM-1 and sR-selectine using R&D Sys...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2004-05-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/29786 |
| _version_ | 1819005252136861696 |
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| author | R Т Alekperov A V Timchenko M Yu Samsonov N G Guseva E L Nasonov |
| author_facet | R Т Alekperov A V Timchenko M Yu Samsonov N G Guseva E L Nasonov |
| author_sort | R Т Alekperov |
| collection | DOAJ |
| description | Aim. To study content and clinical correlations ofsTNF-RI in patients with systemic sclerosis (SS). Material and methods. Thirty nine SS patients were examined with enzyme immunoassay for serum levels of sTNF-RIand soluble adhesion molecules (sSAM) sVSAM-1, sISAM-1 and sR-selectine using R&D System kits (USA). The control group consisted of 14 healthy subjects (donors). Content of sTNF-RI and sSAM was considered as elevated if it exceeded relevant mean values by 1SD. Results. sTNF-RI content was significantly higher in the patients than in the controls (p = 0.0001) and was similar inpatients with diffuse and limited forms of the disease. A rise in sTNF-RI correlated with a rise in pulmonary artery pressure. In patients with pulmonary hypertension or restrictive pulmonary affection sTNF-RIwas higher than in patients free of pulmonary hypertension or impaired external respiration function. A marked correlation was found between sTNF-RI and sVSAM-1. Patients with high CRP had significantly higher sTNF-RI level than patients with normal CRP. Conclusion. SS is characterized by elevated content ofsTNF-RI. This content may serve a diagnostic marker of the disease progression. |
| first_indexed | 2024-12-20T23:49:50Z |
| format | Article |
| id | doaj.art-cb23dfeaa1334178a801d8f36b9e9ea3 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-20T23:49:50Z |
| publishDate | 2004-05-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-cb23dfeaa1334178a801d8f36b9e9ea32022-12-21T19:22:52Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422004-05-01795111526814The level of TNF soluble receptor type 1 in patients with systemic sclerosisR Т AlekperovA V TimchenkoM Yu SamsonovN G GusevaE L NasonovAim. To study content and clinical correlations ofsTNF-RI in patients with systemic sclerosis (SS). Material and methods. Thirty nine SS patients were examined with enzyme immunoassay for serum levels of sTNF-RIand soluble adhesion molecules (sSAM) sVSAM-1, sISAM-1 and sR-selectine using R&D System kits (USA). The control group consisted of 14 healthy subjects (donors). Content of sTNF-RI and sSAM was considered as elevated if it exceeded relevant mean values by 1SD. Results. sTNF-RI content was significantly higher in the patients than in the controls (p = 0.0001) and was similar inpatients with diffuse and limited forms of the disease. A rise in sTNF-RI correlated with a rise in pulmonary artery pressure. In patients with pulmonary hypertension or restrictive pulmonary affection sTNF-RIwas higher than in patients free of pulmonary hypertension or impaired external respiration function. A marked correlation was found between sTNF-RI and sVSAM-1. Patients with high CRP had significantly higher sTNF-RI level than patients with normal CRP. Conclusion. SS is characterized by elevated content ofsTNF-RI. This content may serve a diagnostic marker of the disease progression.https://ter-arkhiv.ru/0040-3660/article/view/29786systemic sclerosistnf-ri |
| spellingShingle | R Т Alekperov A V Timchenko M Yu Samsonov N G Guseva E L Nasonov The level of TNF soluble receptor type 1 in patients with systemic sclerosis Терапевтический архив systemic sclerosis tnf-ri |
| title | The level of TNF soluble receptor type 1 in patients with systemic sclerosis |
| title_full | The level of TNF soluble receptor type 1 in patients with systemic sclerosis |
| title_fullStr | The level of TNF soluble receptor type 1 in patients with systemic sclerosis |
| title_full_unstemmed | The level of TNF soluble receptor type 1 in patients with systemic sclerosis |
| title_short | The level of TNF soluble receptor type 1 in patients with systemic sclerosis |
| title_sort | level of tnf soluble receptor type 1 in patients with systemic sclerosis |
| topic | systemic sclerosis tnf-ri |
| url | https://ter-arkhiv.ru/0040-3660/article/view/29786 |
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