Profiling the secretion of soluble mediators by end stage osteoarthritis synovial tissue explants reveals a reduced responsiveness to an inflammatory trigger.

Profiling the secretion of soluble mediators by end stage osteoarthritis synovial tissue explants reveals a reduced responsiveness to an inflammatory trigger.

OBJECTIVE: Evidence is accumulating that synovial tissue plays an active role in osteoarthritis (OA), however, exact understanding of its contribution is lacking. In order to further elucidate its role in the OA process, we aimed to identify the secretion pattern of soluble mediators by synovial tis...

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Main Authors: Lobke M Gierman, Benno van El, Frits van der Ham, Angela Koudijs, Reinout Stoop, Jan H Verheijen, Margreet Kloppenburg, Gerjo J V M van Osch, Vedrana Stojanovic-Susulic, Tom W J Huizinga, Anne-Marie Zuurmond
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3643929?pdf=render

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