Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

Pyroglutamate and Isoaspartate modified Amyloid-Beta in ageing and Alzheimer’s disease

Abstract Alzheimer’s disease (AD) is the most common cause of dementia among older adults. Accumulation of amyloid-β (Aβ) in the brain is considered central in AD pathogenesis and its understanding crucial for developing new diagnostic and therapeutic approaches. Recent literature suggests that agei...

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Bibliographic Details
Main Authors: Maria Luisa Moro, Andrew Stephen Phillips, Katie Gaimster, Christian Paul, Amritpal Mudher, James A. R. Nicoll, Delphine Boche
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Acta Neuropathologica Communications
Subjects:
IsoAspartate
Pyroglutamate
Alzheimer’s disease
Amyloid-beta
Ageing
Online Access:http://link.springer.com/article/10.1186/s40478-017-0505-x

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