Bioactive Compounds from Marine Sponges: Fundamentals and Applications
Marine sponges are sessile invertebrates that can be found in temperate, polar and tropical regions. They are known to be major contributors of bioactive compounds, which are discovered in and extracted from the marine environment. The compounds extracted from these sponges are known to exhibit vari...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/5/246 |
| _version_ | 1797536206817329152 |
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| author | Disha Varijakzhan Jiun-Yan Loh Wai-Sum Yap Khatijah Yusoff Rabiha Seboussi Swee-Hua Erin Lim Kok-Song Lai Chou-Min Chong |
| author_facet | Disha Varijakzhan Jiun-Yan Loh Wai-Sum Yap Khatijah Yusoff Rabiha Seboussi Swee-Hua Erin Lim Kok-Song Lai Chou-Min Chong |
| author_sort | Disha Varijakzhan |
| collection | DOAJ |
| description | Marine sponges are sessile invertebrates that can be found in temperate, polar and tropical regions. They are known to be major contributors of bioactive compounds, which are discovered in and extracted from the marine environment. The compounds extracted from these sponges are known to exhibit various bioactivities, such as antimicrobial, antitumor and general cytotoxicity. For example, various compounds isolated from <i>Theonella swinhoei</i> have showcased various bioactivities, such as those that are antibacterial, antiviral and antifungal. In this review, we discuss bioactive compounds that have been identified from marine sponges that showcase the ability to act as antibacterial, antiviral, anti-malarial and antifungal agents against human pathogens and fish pathogens in the aquaculture industry. Moreover, the application of such compounds as antimicrobial agents in other veterinary commodities, such as poultry, cattle farming and domesticated cats, is discussed, along with a brief discussion regarding the mode of action of these compounds on the targeted sites in various pathogens. The bioactivity of the compounds discussed in this review is focused mainly on compounds that have been identified between 2000 and 2020 and includes the novel compounds discovered from 2018 to 2021. |
| first_indexed | 2024-03-10T11:56:21Z |
| format | Article |
| id | doaj.art-cb255e9201cc43e084a075594f04af4f |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T11:56:21Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-cb255e9201cc43e084a075594f04af4f2023-11-21T17:19:19ZengMDPI AGMarine Drugs1660-33972021-04-0119524610.3390/md19050246Bioactive Compounds from Marine Sponges: Fundamentals and ApplicationsDisha Varijakzhan0Jiun-Yan Loh1Wai-Sum Yap2Khatijah Yusoff3Rabiha Seboussi4Swee-Hua Erin Lim5Kok-Song Lai6Chou-Min Chong7Aquatic Animal Health and Therapeutics Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, MalaysiaFaculty of Applied Sciences, UCSI University, No. 1, Jalan Menara Gading, UCSI Heights, Cheras, Kuala Lumpur 56000, MalaysiaFaculty of Applied Sciences, UCSI University, No. 1, Jalan Menara Gading, UCSI Heights, Cheras, Kuala Lumpur 56000, MalaysiaDepartment of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang 43400, MalaysiaHealth Sciences Division, Al Ain Men’s College, Higher Colleges of Technology, Al Ain 17155, United Arab EmiratesHealth Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, Abu Dhabi 41012, United Arab EmiratesHealth Sciences Division, Abu Dhabi Women’s College, Higher Colleges of Technology, Abu Dhabi 41012, United Arab EmiratesAquatic Animal Health and Therapeutics Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang 43400, MalaysiaMarine sponges are sessile invertebrates that can be found in temperate, polar and tropical regions. They are known to be major contributors of bioactive compounds, which are discovered in and extracted from the marine environment. The compounds extracted from these sponges are known to exhibit various bioactivities, such as antimicrobial, antitumor and general cytotoxicity. For example, various compounds isolated from <i>Theonella swinhoei</i> have showcased various bioactivities, such as those that are antibacterial, antiviral and antifungal. In this review, we discuss bioactive compounds that have been identified from marine sponges that showcase the ability to act as antibacterial, antiviral, anti-malarial and antifungal agents against human pathogens and fish pathogens in the aquaculture industry. Moreover, the application of such compounds as antimicrobial agents in other veterinary commodities, such as poultry, cattle farming and domesticated cats, is discussed, along with a brief discussion regarding the mode of action of these compounds on the targeted sites in various pathogens. The bioactivity of the compounds discussed in this review is focused mainly on compounds that have been identified between 2000 and 2020 and includes the novel compounds discovered from 2018 to 2021.https://www.mdpi.com/1660-3397/19/5/246marine spongebioactive compoundsmicrobial symbiontsantimicrobial activityaquaculturequorum quenching |
| spellingShingle | Disha Varijakzhan Jiun-Yan Loh Wai-Sum Yap Khatijah Yusoff Rabiha Seboussi Swee-Hua Erin Lim Kok-Song Lai Chou-Min Chong Bioactive Compounds from Marine Sponges: Fundamentals and Applications Marine Drugs marine sponge bioactive compounds microbial symbionts antimicrobial activity aquaculture quorum quenching |
| title | Bioactive Compounds from Marine Sponges: Fundamentals and Applications |
| title_full | Bioactive Compounds from Marine Sponges: Fundamentals and Applications |
| title_fullStr | Bioactive Compounds from Marine Sponges: Fundamentals and Applications |
| title_full_unstemmed | Bioactive Compounds from Marine Sponges: Fundamentals and Applications |
| title_short | Bioactive Compounds from Marine Sponges: Fundamentals and Applications |
| title_sort | bioactive compounds from marine sponges fundamentals and applications |
| topic | marine sponge bioactive compounds microbial symbionts antimicrobial activity aquaculture quorum quenching |
| url | https://www.mdpi.com/1660-3397/19/5/246 |
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