Atomic force microscopy reveals involvement of the cell envelope in biomechanical properties of sickle erythrocytes

Atomic force microscopy reveals involvement of the cell envelope in biomechanical properties of sickle erythrocytes

Abstract Background Intracellular hemoglobin polymerization has been supposed to be the major determinant for the elevated rigidity/stiffness of sickle erythrocytes from sickle cell anemia (SCA) patients. However, the contribution of the cell envelope remains unclear. Results In this study, using at...

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Bibliographic Details
Main Authors: Kun Wang, Zhiqiang Li, Ogechukwu Egini, Raj Wadgaonkar, Xian-Cheng Jiang, Yong Chen
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Biology
Subjects:
Sickle cell anemia (SCA)
Sickle erythrocytes
Atomic force microscopy (AFM)
Membrane ghosts
Methyl-β-cyclodextrin (MβCD)
Stiffness
Online Access:https://doi.org/10.1186/s12915-023-01523-3

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