Inadequate glycemic control in patients receiving parenteral nutrition lowers survival: A retrospective observational trial
Background & aims: Parenteral Nutrition (PN) has been shown to cause glycemic deregulation, whether patients have type 2 diabetes (T2DM) or not, causing elevated mortality, despite intensive insulin treatment. Long-term effects, however, are unclear. Methods: A retrospective observational study...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-02-01
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| Series: | Clinical Nutrition Experimental |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352939317300507 |
| _version_ | 1819206845544267776 |
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| author | Elien Coudenys Elisabeth De Waele Garmt Meers Hilde Collier Joeri J. Pen |
| author_facet | Elien Coudenys Elisabeth De Waele Garmt Meers Hilde Collier Joeri J. Pen |
| author_sort | Elien Coudenys |
| collection | DOAJ |
| description | Background & aims: Parenteral Nutrition (PN) has been shown to cause glycemic deregulation, whether patients have type 2 diabetes (T2DM) or not, causing elevated mortality, despite intensive insulin treatment. Long-term effects, however, are unclear.
Methods: A retrospective observational study was performed. 226 patients of the UZ Brussel, both T2DM patients and non-diabetics, who received PN in 2013 or 2014, were analyzed on the presence of hyperglycemia and hypoglycemia, as well as mortality in-hospital and after 6 months.
Results: Here we show that T2DM patients displaying either hyper- or hypoglycemia, had a significant higher mortality. This was the case both in-hospital and after 6 months. Non-diabetics undergoing hyperglycemia had a similar fate, but not when these patients had hypoglycemic events.
Conclusion: Whether PN-receiving patients had T2DM or were non-diabetic, hyperglycemia was related to mortality, both in-hospital and after 6 months, whereas hypoglycemia was only related to mortality in T2DM patients. |
| first_indexed | 2024-12-23T05:14:04Z |
| format | Article |
| id | doaj.art-cb2907c871d64244947ecda7eb2919d7 |
| institution | Directory Open Access Journal |
| issn | 2352-9393 |
| language | English |
| last_indexed | 2024-12-23T05:14:04Z |
| publishDate | 2018-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Experimental |
| spelling | doaj.art-cb2907c871d64244947ecda7eb2919d72022-12-21T17:58:54ZengElsevierClinical Nutrition Experimental2352-93932018-02-0117C1710.1016/j.yclnex.2017.12.001Inadequate glycemic control in patients receiving parenteral nutrition lowers survival: A retrospective observational trialElien Coudenys0Elisabeth De Waele1Garmt Meers2Hilde Collier3Joeri J. Pen4Department of Internal Medicine, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, BelgiumDepartment of Nutrition, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, BelgiumHospital Pharmacy, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, BelgiumHospital Pharmacy, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, BelgiumDepartment of Nutrition, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, BelgiumBackground & aims: Parenteral Nutrition (PN) has been shown to cause glycemic deregulation, whether patients have type 2 diabetes (T2DM) or not, causing elevated mortality, despite intensive insulin treatment. Long-term effects, however, are unclear. Methods: A retrospective observational study was performed. 226 patients of the UZ Brussel, both T2DM patients and non-diabetics, who received PN in 2013 or 2014, were analyzed on the presence of hyperglycemia and hypoglycemia, as well as mortality in-hospital and after 6 months. Results: Here we show that T2DM patients displaying either hyper- or hypoglycemia, had a significant higher mortality. This was the case both in-hospital and after 6 months. Non-diabetics undergoing hyperglycemia had a similar fate, but not when these patients had hypoglycemic events. Conclusion: Whether PN-receiving patients had T2DM or were non-diabetic, hyperglycemia was related to mortality, both in-hospital and after 6 months, whereas hypoglycemia was only related to mortality in T2DM patients.http://www.sciencedirect.com/science/article/pii/S2352939317300507HyperglycemiaHypoglycemiaParenteral nutritionMortality |
| spellingShingle | Elien Coudenys Elisabeth De Waele Garmt Meers Hilde Collier Joeri J. Pen Inadequate glycemic control in patients receiving parenteral nutrition lowers survival: A retrospective observational trial Clinical Nutrition Experimental Hyperglycemia Hypoglycemia Parenteral nutrition Mortality |
| title | Inadequate glycemic control in patients receiving parenteral nutrition lowers survival: A retrospective observational trial |
| title_full | Inadequate glycemic control in patients receiving parenteral nutrition lowers survival: A retrospective observational trial |
| title_fullStr | Inadequate glycemic control in patients receiving parenteral nutrition lowers survival: A retrospective observational trial |
| title_full_unstemmed | Inadequate glycemic control in patients receiving parenteral nutrition lowers survival: A retrospective observational trial |
| title_short | Inadequate glycemic control in patients receiving parenteral nutrition lowers survival: A retrospective observational trial |
| title_sort | inadequate glycemic control in patients receiving parenteral nutrition lowers survival a retrospective observational trial |
| topic | Hyperglycemia Hypoglycemia Parenteral nutrition Mortality |
| url | http://www.sciencedirect.com/science/article/pii/S2352939317300507 |
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