Candida tropicalis as a Predominant Isolate from Clinical Specimens and its Antifungal Susceptibility Pattern in a Tertiary Care Hospital in Southern India
Background: The incidence of infections caused by Candida species has increased considerably over the past three decades mainly due to the rise of the AIDS epidemic, an increasingly aged population, higher numbers of immunocompromised patients and the more widespread use of indwelling medical d...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-07-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6208/13460_CE[Ra]_F(P)_PF1(PAK)_PFA(P)_PF2(PAG).pdf |
| Summary: | Background: The incidence of infections caused by Candida
species has increased considerably over the past three decades
mainly due to the rise of the AIDS epidemic, an increasingly
aged population, higher numbers of immunocompromised
patients and the more widespread use of indwelling medical
devices. Candida tropicalis is emerging pathogenic yeast among
non-albicans species. Recently drug-resistant C.tropicalis was
also reported in hospitals.
Aim and Objective: The present study aimed to isolate and
speciate C. tropicalis from various clinical samples and to
determine its antifungal susceptibility profile.
Materials and Methods: Clinical samples such as urine,
blood, exudates and vaginal swab which were submitted to the
Microbiology laboratory during the year 2013 were screened
for the growth of Candidia species, which then identified as
C.tropicalis by the routine microbiological procedures such as
germ tube formation, assimilation and fermentation of sugars
and colony color on HICHROM Candida agar. Antifungal
susceptibility was performed by disc diffusion method with
the drugs Amphotericin-B, Itraconazole, Ketaconazole and
Fluconazole on C. tropicalis isolates.
Results: A total number of 112 Candida isolates were isolated
during the year 2012 from various clinical specimens. Among
them 61 (54.3%) were identified as C.tropicalis. All the C.
tropicalis isolates were sensitive to Amphotericin-B (100%) but
23 isolates (37.7%) were resistant to Fluconazole.
Conclusion: We conclude that identification of Candida species
is important to know the prevalent species in the clinical setup
and routine antifungal susceptibility should be performed to
avoid inappropriate treatment. |
|---|---|
| ISSN: | 2249-782X 0973-709X |