Initial symptoms and three months follow-up after acute COVID-19 in outpatients: An international prospective cohort study
AbstractBackground Most studies on long-term follow-up of patients with COVID-19 focused on hospitalised patients. No prospective study with structured follow-up has been performed in non-hospitalised patients with COVID-19.Objectives To assess long-COVID and post-COVID (WHO definition: symptomatic...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | European Journal of General Practice |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/13814788.2022.2154074 |
| _version_ | 1797809674541596672 |
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| author | Katarina Hedin Alike W. van der Velden Malene Plejdrup Hansen Anna B. Moberg Anca Balan Pascale Bruno Samuel Coenen Eskild Johansen Anna Kowalczyk Peter Konstantin Kurotschka Sanne R. van der Linde Lile Malania Jörn Rohde Jan Verbakel Heike Vornhagen Akke Vellinga |
| author_facet | Katarina Hedin Alike W. van der Velden Malene Plejdrup Hansen Anna B. Moberg Anca Balan Pascale Bruno Samuel Coenen Eskild Johansen Anna Kowalczyk Peter Konstantin Kurotschka Sanne R. van der Linde Lile Malania Jörn Rohde Jan Verbakel Heike Vornhagen Akke Vellinga |
| author_sort | Katarina Hedin |
| collection | DOAJ |
| description | AbstractBackground Most studies on long-term follow-up of patients with COVID-19 focused on hospitalised patients. No prospective study with structured follow-up has been performed in non-hospitalised patients with COVID-19.Objectives To assess long-COVID and post-COVID (WHO definition: symptomatic at least 12 weeks), describe lingering symptoms, their impact on daily activities, and general practice visits and explore risk factors for symptom duration in outpatients.Methods A prospective study of adult outpatients with confirmed SARS-CoV-2 infection and symptoms consistent with COVID-19 in 11 European countries, recruited during 2020 and 2021 from primary care and the community. Structured follow-up by phone interviews (symptom rating, symptom impact on daily activities and general practice visits) was performed at weeks 2, 4, 8, and 12 by study personnel. Data was analysed descriptively by using correlation matrixes and Cox regression.Results Of 270 enrolled patients, 52% developed long-COVID and 32% post-COVID-syndrome. When only considering the presence of moderate or (very) severe symptoms at weeks 8 and 12, these percentages were 28% and 18%, respectively. Fatigue was the most often reported symptom during follow-up. The impact of lingering symptoms was most evident in sports and household activities. About half (53%) had at least one general practice contact during follow-up. Obese patients took twice as long to return to usual health (HR: 0.5, 95%CI: 0.3–0.8); no other risk profile could predict lingering symptoms.Conclusion Long-COVID and post-COVID are also common in outpatients. In 32%, it takes more than 12 weeks to return to usual health. |
| first_indexed | 2024-03-13T06:56:14Z |
| format | Article |
| id | doaj.art-cb2c0da404d541518fadb766054c3e47 |
| institution | Directory Open Access Journal |
| issn | 1381-4788 1751-1402 |
| language | English |
| last_indexed | 2024-03-13T06:56:14Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | European Journal of General Practice |
| spelling | doaj.art-cb2c0da404d541518fadb766054c3e472023-06-07T08:32:34ZengTaylor & Francis GroupEuropean Journal of General Practice1381-47881751-14022023-12-0129210.1080/13814788.2022.2154074Initial symptoms and three months follow-up after acute COVID-19 in outpatients: An international prospective cohort studyKatarina Hedin0Alike W. van der Velden1Malene Plejdrup Hansen2Anna B. Moberg3Anca Balan4Pascale Bruno5Samuel Coenen6Eskild Johansen7Anna Kowalczyk8Peter Konstantin Kurotschka9Sanne R. van der Linde10Lile Malania11Jörn Rohde12Jan Verbakel13Heike Vornhagen14Akke Vellinga15Futurum, Region Jönköping County, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SwedenJulius Center of Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the NetherlandsCenter for General Practice at, Aalborg University, Aalborg, DenmarkDepartment of Health, Medicine and Caring Sciences, Linköping University, Linköping, SwedenBalan Medfarm SRL, Cluj Napoca, RomaniaDépartement de Santé Publique, Université Côte d’Azur, Centre Hospitalier Universitaire de Nice, Nice, FranceCentre for General Practice, Department of Family Medicine & Population Health, University of Antwerp, Antwerp (Wilrijk), BelgiumCenter for General Practice at, Aalborg University, Aalborg, DenmarkCentre for Family and Community Medicine, the Faculty of Health Sciences, the Medical University of Lodz, Lodz, PolandDepartment of General Practice, University Hospital Würzburg, Würzburg, GermanyJulius Center of Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the NetherlandsNational Center for Disease Control and Public Health, Tbilisi, GeorgiaDepartment of General Practice, University Hospital Würzburg, Würzburg, GermanyEPI-Centre, Department of Public Health and Primary Care, KU Leuven, Leuven, BelgiumData Science Institute, National University of Galway, Galway, IrelandSchool of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, IrelandAbstractBackground Most studies on long-term follow-up of patients with COVID-19 focused on hospitalised patients. No prospective study with structured follow-up has been performed in non-hospitalised patients with COVID-19.Objectives To assess long-COVID and post-COVID (WHO definition: symptomatic at least 12 weeks), describe lingering symptoms, their impact on daily activities, and general practice visits and explore risk factors for symptom duration in outpatients.Methods A prospective study of adult outpatients with confirmed SARS-CoV-2 infection and symptoms consistent with COVID-19 in 11 European countries, recruited during 2020 and 2021 from primary care and the community. Structured follow-up by phone interviews (symptom rating, symptom impact on daily activities and general practice visits) was performed at weeks 2, 4, 8, and 12 by study personnel. Data was analysed descriptively by using correlation matrixes and Cox regression.Results Of 270 enrolled patients, 52% developed long-COVID and 32% post-COVID-syndrome. When only considering the presence of moderate or (very) severe symptoms at weeks 8 and 12, these percentages were 28% and 18%, respectively. Fatigue was the most often reported symptom during follow-up. The impact of lingering symptoms was most evident in sports and household activities. About half (53%) had at least one general practice contact during follow-up. Obese patients took twice as long to return to usual health (HR: 0.5, 95%CI: 0.3–0.8); no other risk profile could predict lingering symptoms.Conclusion Long-COVID and post-COVID are also common in outpatients. In 32%, it takes more than 12 weeks to return to usual health.https://www.tandfonline.com/doi/10.1080/13814788.2022.2154074COVID-19primary carelingering symptomsdaily activitiespost-COVIDlong-COVID |
| spellingShingle | Katarina Hedin Alike W. van der Velden Malene Plejdrup Hansen Anna B. Moberg Anca Balan Pascale Bruno Samuel Coenen Eskild Johansen Anna Kowalczyk Peter Konstantin Kurotschka Sanne R. van der Linde Lile Malania Jörn Rohde Jan Verbakel Heike Vornhagen Akke Vellinga Initial symptoms and three months follow-up after acute COVID-19 in outpatients: An international prospective cohort study European Journal of General Practice COVID-19 primary care lingering symptoms daily activities post-COVID long-COVID |
| title | Initial symptoms and three months follow-up after acute COVID-19 in outpatients: An international prospective cohort study |
| title_full | Initial symptoms and three months follow-up after acute COVID-19 in outpatients: An international prospective cohort study |
| title_fullStr | Initial symptoms and three months follow-up after acute COVID-19 in outpatients: An international prospective cohort study |
| title_full_unstemmed | Initial symptoms and three months follow-up after acute COVID-19 in outpatients: An international prospective cohort study |
| title_short | Initial symptoms and three months follow-up after acute COVID-19 in outpatients: An international prospective cohort study |
| title_sort | initial symptoms and three months follow up after acute covid 19 in outpatients an international prospective cohort study |
| topic | COVID-19 primary care lingering symptoms daily activities post-COVID long-COVID |
| url | https://www.tandfonline.com/doi/10.1080/13814788.2022.2154074 |
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