A New Multi-Component Solid of Atorvastatin Calcium with a Dipicolinic Acid Coformer for Improving the Water Solubility
Atorvastatin calcium is a potent active pharmaceutical ingredient that reduces blood cholesterol levels. However, oral bioavailability is low because it is difficult to dissolve in water. Therefore, further research to increase the solubility of the drug is needed to improve its bioavailability...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Indonesia
2023-05-01
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| Series: | International Journal of Technology |
| Subjects: | |
| Online Access: | https://ijtech.eng.ui.ac.id/article/view/5088 |
| Summary: | Atorvastatin
calcium is a potent active
pharmaceutical ingredient that reduces blood cholesterol
levels. However, oral bioavailability is low because it is difficult to
dissolve in water. Therefore, further research to increase the solubility of
the drug is needed to improve its bioavailability properties. This research aimed
to increase the solubility of atorvastatin calcium through the formation of a
multi-component solid. Furthermore, the drug was formed into a multi-component
solid with dipicolinic acid as a coformer using the solvent
evaporation-quenching method. A powder X-ray diffractometer (PXRD), Fourier
transform infrared (FTIR) spectrometer, differential scanning calorimeter
(DSC), and scanning electron microscope (SEM) was used to characterize the
solid. Also, the shake-flask method was used to analyze the solubility of the
solid in distilled water. The results showed that atorvastatin calcium and
dipicolinic acid formed a new multi-component solid of cocrystal type. The solubility of the atorvastatin calcium from the
multi-component solid was 344.31 ± 37.09 mg/L, which was a significant increase
of about 2.7-fold compared to the pure form. |
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| ISSN: | 2086-9614 2087-2100 |