Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease
Coagulopathy in COVID-19 patients is presumably based on systemic hypercoagulation with the inflammatory response. As a result of endothelial dysfunction, tissue factor and von Willebrand factor (vWF) are released into the blood stream, which leads to prothrombinase activation. The vWF/ADAMTS-13 rat...
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MDPI AG
2022-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/14/4006 |
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| author | Nataliya Dolgushina Elena Gorodnova Olga Beznoshenco Andrey Romanov Irina Menzhinskaya Lyubov Krechetova Gennady Sukhikh |
| author_facet | Nataliya Dolgushina Elena Gorodnova Olga Beznoshenco Andrey Romanov Irina Menzhinskaya Lyubov Krechetova Gennady Sukhikh |
| author_sort | Nataliya Dolgushina |
| collection | DOAJ |
| description | Coagulopathy in COVID-19 patients is presumably based on systemic hypercoagulation with the inflammatory response. As a result of endothelial dysfunction, tissue factor and von Willebrand factor (vWF) are released into the blood stream, which leads to prothrombinase activation. The vWF/ADAMTS-13 ratio can be used for monitoring the severity of the disease. This observational prospective study included 141 patients with COVID-19. In patients with mild COVID-19 (group 1), the assessment was performed on the 3rd–7th day of illness (point 1) and 14–28 days after recovery (point 2). In patients with moderate (groups 2) and severe (group 3) COVID-19, the assessment was performed during hospitalization (point 1) and after 14 days (point 2). The vWF:RCo/ADAMTS-13:activity (point 1), vWF/ADAMTS-13 (point 2) and vWF:RCo/ADAMTS-13:activity (point 2) ratios were significantly higher in patients with moderate and severe COVID-19. Moreover, in these patients, both ratios increased after recovery (point 2), which is a negative prognostic factor of thrombotic complications. Thus, COVID-19 is characterized by a decrease in the concentration and activity of ADAMTS-13 metalloproteinase, especially in patients with the severe form of COVID-19. A decrease in ADAMTS-13 activity results in an increase in vWF concentration and activity so the ratio of vWF to ADAMTS-13 changes significantly. |
| first_indexed | 2024-03-09T10:17:44Z |
| format | Article |
| id | doaj.art-cb2f0e52246e4295a71170abfd0cf5c5 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T10:17:44Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-cb2f0e52246e4295a71170abfd0cf5c52023-12-01T22:17:55ZengMDPI AGJournal of Clinical Medicine2077-03832022-07-011114400610.3390/jcm11144006Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 DiseaseNataliya Dolgushina0Elena Gorodnova1Olga Beznoshenco2Andrey Romanov3Irina Menzhinskaya4Lyubov Krechetova5Gennady Sukhikh6National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 117997 Moscow, RussiaCoagulopathy in COVID-19 patients is presumably based on systemic hypercoagulation with the inflammatory response. As a result of endothelial dysfunction, tissue factor and von Willebrand factor (vWF) are released into the blood stream, which leads to prothrombinase activation. The vWF/ADAMTS-13 ratio can be used for monitoring the severity of the disease. This observational prospective study included 141 patients with COVID-19. In patients with mild COVID-19 (group 1), the assessment was performed on the 3rd–7th day of illness (point 1) and 14–28 days after recovery (point 2). In patients with moderate (groups 2) and severe (group 3) COVID-19, the assessment was performed during hospitalization (point 1) and after 14 days (point 2). The vWF:RCo/ADAMTS-13:activity (point 1), vWF/ADAMTS-13 (point 2) and vWF:RCo/ADAMTS-13:activity (point 2) ratios were significantly higher in patients with moderate and severe COVID-19. Moreover, in these patients, both ratios increased after recovery (point 2), which is a negative prognostic factor of thrombotic complications. Thus, COVID-19 is characterized by a decrease in the concentration and activity of ADAMTS-13 metalloproteinase, especially in patients with the severe form of COVID-19. A decrease in ADAMTS-13 activity results in an increase in vWF concentration and activity so the ratio of vWF to ADAMTS-13 changes significantly.https://www.mdpi.com/2077-0383/11/14/4006COVID-19von Willebrand factorADAMTS-13hypercoagulationthrombosis |
| spellingShingle | Nataliya Dolgushina Elena Gorodnova Olga Beznoshenco Andrey Romanov Irina Menzhinskaya Lyubov Krechetova Gennady Sukhikh Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease Journal of Clinical Medicine COVID-19 von Willebrand factor ADAMTS-13 hypercoagulation thrombosis |
| title | Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease |
| title_full | Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease |
| title_fullStr | Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease |
| title_full_unstemmed | Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease |
| title_short | Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease |
| title_sort | von willebrand factor and adamts 13 are associated with the severity of covid 19 disease |
| topic | COVID-19 von Willebrand factor ADAMTS-13 hypercoagulation thrombosis |
| url | https://www.mdpi.com/2077-0383/11/14/4006 |
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