Association between testosterone and serum soluble α-klotho in U.S. males: a cross-sectional study
Abstract Purpose Testosterone plays a crucial role in males, and the deficiency of testosterone leads to multiple adverse health conditions. Klotho is a recently discovered protein encoded by antiaging gene klotho. Both the levels of testosterone and klotho change with aging, so the relationship bet...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-022-03265-3 |
| _version_ | 1811293606711918592 |
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| author | Zilong Zhang Shi Qiu Xinyi Huang Kun Jin Xianghong Zhou Tianhai Lin Xiaoli Zou Qiuxiang Yang Lu Yang Qiang Wei |
| author_facet | Zilong Zhang Shi Qiu Xinyi Huang Kun Jin Xianghong Zhou Tianhai Lin Xiaoli Zou Qiuxiang Yang Lu Yang Qiang Wei |
| author_sort | Zilong Zhang |
| collection | DOAJ |
| description | Abstract Purpose Testosterone plays a crucial role in males, and the deficiency of testosterone leads to multiple adverse health conditions. Klotho is a recently discovered protein encoded by antiaging gene klotho. Both the levels of testosterone and klotho change with aging, so the relationship between them is worth exploring. The purpose of this study was to investigate whether total testosterone is associated with serum klotho levels in U.S. males aged 40–79 years. Methods Included in this study were 3750 male participants from the 2011 to 2016 National Health and Nutrition Examination Survey, aged 40–79 years with included information on klotho and sex hormones. The sex steroid hormone levels and klotho concentrations were assayed in laboratories using the recommended methods according to Nutrition Examination Survey guidelines. The association between sex hormones and klotho was calculated using multivariate linear regression models after adjustment for several possible confounding variables. Results Among the 3750 participants, the total testosterone concentration was 399.048 ± 184.780 ng/dL, and the testosterone deficiency prevalence was 1160 (30.942%). The geometric mean of serum klotho levels was 791.000 pg/mL. In the adjusted models, klotho increased 0.165 pg/mL for every 1 ng/dL increase of total testosterone (p = 0.004). In addition, estradiol (β 2.232; 95% CI 0.588–3.876; p = 0.032) and sex hormone-binding globulin (β 2.013; 95% CI 1.173–2.583; p = 0.002) were also positively associated with klotho concentrations. Conclusion This study reported a significant association between klotho and sex hormones in the U.S. male population. The levels of klotho in men increased with total testosterone, estradiol and sex hormone-binding globulin levels, which may have implications for future research and clinical practice. |
| first_indexed | 2024-04-13T05:03:57Z |
| format | Article |
| id | doaj.art-cb314d1e47224ee78c703095d5249526 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-04-13T05:03:57Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-cb314d1e47224ee78c703095d52495262022-12-22T03:01:14ZengBMCBMC Geriatrics1471-23182022-07-012211810.1186/s12877-022-03265-3Association between testosterone and serum soluble α-klotho in U.S. males: a cross-sectional studyZilong Zhang0Shi Qiu1Xinyi Huang2Kun Jin3Xianghong Zhou4Tianhai Lin5Xiaoli Zou6Qiuxiang Yang7Lu Yang8Qiang Wei9Department of Urology and Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Urology and Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityDepartment of Urology and Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Urology and Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Urology and Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityWest China School of Public Health and West China Fourth Hospital, Sichuan UniversityDepartment of Urology and Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Urology and Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityDepartment of Urology and Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan UniversityAbstract Purpose Testosterone plays a crucial role in males, and the deficiency of testosterone leads to multiple adverse health conditions. Klotho is a recently discovered protein encoded by antiaging gene klotho. Both the levels of testosterone and klotho change with aging, so the relationship between them is worth exploring. The purpose of this study was to investigate whether total testosterone is associated with serum klotho levels in U.S. males aged 40–79 years. Methods Included in this study were 3750 male participants from the 2011 to 2016 National Health and Nutrition Examination Survey, aged 40–79 years with included information on klotho and sex hormones. The sex steroid hormone levels and klotho concentrations were assayed in laboratories using the recommended methods according to Nutrition Examination Survey guidelines. The association between sex hormones and klotho was calculated using multivariate linear regression models after adjustment for several possible confounding variables. Results Among the 3750 participants, the total testosterone concentration was 399.048 ± 184.780 ng/dL, and the testosterone deficiency prevalence was 1160 (30.942%). The geometric mean of serum klotho levels was 791.000 pg/mL. In the adjusted models, klotho increased 0.165 pg/mL for every 1 ng/dL increase of total testosterone (p = 0.004). In addition, estradiol (β 2.232; 95% CI 0.588–3.876; p = 0.032) and sex hormone-binding globulin (β 2.013; 95% CI 1.173–2.583; p = 0.002) were also positively associated with klotho concentrations. Conclusion This study reported a significant association between klotho and sex hormones in the U.S. male population. The levels of klotho in men increased with total testosterone, estradiol and sex hormone-binding globulin levels, which may have implications for future research and clinical practice.https://doi.org/10.1186/s12877-022-03265-3Sex hormonesSoluble α-KlothoNHANES |
| spellingShingle | Zilong Zhang Shi Qiu Xinyi Huang Kun Jin Xianghong Zhou Tianhai Lin Xiaoli Zou Qiuxiang Yang Lu Yang Qiang Wei Association between testosterone and serum soluble α-klotho in U.S. males: a cross-sectional study BMC Geriatrics Sex hormones Soluble α-Klotho NHANES |
| title | Association between testosterone and serum soluble α-klotho in U.S. males: a cross-sectional study |
| title_full | Association between testosterone and serum soluble α-klotho in U.S. males: a cross-sectional study |
| title_fullStr | Association between testosterone and serum soluble α-klotho in U.S. males: a cross-sectional study |
| title_full_unstemmed | Association between testosterone and serum soluble α-klotho in U.S. males: a cross-sectional study |
| title_short | Association between testosterone and serum soluble α-klotho in U.S. males: a cross-sectional study |
| title_sort | association between testosterone and serum soluble α klotho in u s males a cross sectional study |
| topic | Sex hormones Soluble α-Klotho NHANES |
| url | https://doi.org/10.1186/s12877-022-03265-3 |
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