Prevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia.
<h4>Background</h4>Escherichia coli O157:H7 (E. coli O157:H7) is one of the most potent zoonotic pathogens that causes mild diarrhea and leads to hemolytic uremic syndrome or death. This study was aimed to assess the prevalence and determinants of E. coli O157:H7 related to diarrhea amon...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0246024 |
| _version_ | 1828069972080852992 |
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| author | Dawit Kassaye Getaneh Lemessa Oljira Hordofa Desalegn Admassu Ayana Tesfaye Sisay Tessema Lemma Demissie Regassa |
| author_facet | Dawit Kassaye Getaneh Lemessa Oljira Hordofa Desalegn Admassu Ayana Tesfaye Sisay Tessema Lemma Demissie Regassa |
| author_sort | Dawit Kassaye Getaneh |
| collection | DOAJ |
| description | <h4>Background</h4>Escherichia coli O157:H7 (E. coli O157:H7) is one of the most potent zoonotic pathogens that causes mild diarrhea and leads to hemolytic uremic syndrome or death. This study was aimed to assess the prevalence and determinants of E. coli O157:H7 related to diarrhea among under-five children with acute diarrhea.<h4>Methods</h4>A cross-sectional study design was carried out in 2018 on 378 under-five-year children recruited randomly from hospitals in Eastern Ethiopia. Stool specimens were collected and processed using enrichment, differential and selective medium. Among isolates, E. coli O157:H7 was confirmed using latex test (Oxoid, Basingstoke, Hants, England). Factors associated with E. coli O157:H7 infection were identified using binary and multivariable logistic regression. Associations were reported by odds ratio with 95% confidence interval.<h4>Results</h4>The prevalence of E. coli O157:H7 related diarrhea was 15.3% (95%CI: 11.8-19.5). The E. coli O157:H7 infection was positively associated with rural residence (AOR;3.75, 95%CI:1.26-11.20), consumption of undercooked meat (AOR;3.95, 95%CI: 1.23-12.67), raw vegetables and/or fruit juice (AOR;3.37, 95%CI:1.32-8.62), presence of bloody diarrhea (AOR;4.42, 95% CI:1.78-10.94), number of under-five children in a household (AOR;7.16, 95%CI: 2.90-17.70), presence of person with diarrhea in a household (AOR;4.22, 95% CI: 1.84-12.69), owning domestic animal (AOR;3.87, 95% CI: 1.48-10.12) and uneducated mother (AOR;3.14, 95%CI: 1.05-9.42).<h4>Conclusion</h4>The Prevalence of E. coli O157:H7 related diarrhea among under-five children is relatively high in Eastern Ethiopia. The E. coli infection was associated with sanitation and hygiene in a household. Thus, education focused on food cooking and handling, child care, and household sanitation associated with animal manure in rural resident children are helpful in. |
| first_indexed | 2024-04-11T00:28:48Z |
| format | Article |
| id | doaj.art-cb319fe2d0e3482597599f52ca8986d4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T00:28:48Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cb319fe2d0e3482597599f52ca8986d42023-01-08T05:31:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01161e024602410.1371/journal.pone.0246024Prevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia.Dawit Kassaye GetanehLemessa Oljira HordofaDesalegn Admassu AyanaTesfaye Sisay TessemaLemma Demissie Regassa<h4>Background</h4>Escherichia coli O157:H7 (E. coli O157:H7) is one of the most potent zoonotic pathogens that causes mild diarrhea and leads to hemolytic uremic syndrome or death. This study was aimed to assess the prevalence and determinants of E. coli O157:H7 related to diarrhea among under-five children with acute diarrhea.<h4>Methods</h4>A cross-sectional study design was carried out in 2018 on 378 under-five-year children recruited randomly from hospitals in Eastern Ethiopia. Stool specimens were collected and processed using enrichment, differential and selective medium. Among isolates, E. coli O157:H7 was confirmed using latex test (Oxoid, Basingstoke, Hants, England). Factors associated with E. coli O157:H7 infection were identified using binary and multivariable logistic regression. Associations were reported by odds ratio with 95% confidence interval.<h4>Results</h4>The prevalence of E. coli O157:H7 related diarrhea was 15.3% (95%CI: 11.8-19.5). The E. coli O157:H7 infection was positively associated with rural residence (AOR;3.75, 95%CI:1.26-11.20), consumption of undercooked meat (AOR;3.95, 95%CI: 1.23-12.67), raw vegetables and/or fruit juice (AOR;3.37, 95%CI:1.32-8.62), presence of bloody diarrhea (AOR;4.42, 95% CI:1.78-10.94), number of under-five children in a household (AOR;7.16, 95%CI: 2.90-17.70), presence of person with diarrhea in a household (AOR;4.22, 95% CI: 1.84-12.69), owning domestic animal (AOR;3.87, 95% CI: 1.48-10.12) and uneducated mother (AOR;3.14, 95%CI: 1.05-9.42).<h4>Conclusion</h4>The Prevalence of E. coli O157:H7 related diarrhea among under-five children is relatively high in Eastern Ethiopia. The E. coli infection was associated with sanitation and hygiene in a household. Thus, education focused on food cooking and handling, child care, and household sanitation associated with animal manure in rural resident children are helpful in.https://doi.org/10.1371/journal.pone.0246024 |
| spellingShingle | Dawit Kassaye Getaneh Lemessa Oljira Hordofa Desalegn Admassu Ayana Tesfaye Sisay Tessema Lemma Demissie Regassa Prevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia. PLoS ONE |
| title | Prevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia. |
| title_full | Prevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia. |
| title_fullStr | Prevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia. |
| title_full_unstemmed | Prevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia. |
| title_short | Prevalence of Escherichia coli O157:H7 and associated factors in under-five children in Eastern Ethiopia. |
| title_sort | prevalence of escherichia coli o157 h7 and associated factors in under five children in eastern ethiopia |
| url | https://doi.org/10.1371/journal.pone.0246024 |
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