Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency

Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potency

Abstract Fibroblast growth factor 21 (FGF21) has pharmaceutical potential against obesity-related metabolic disorders, including non-alcoholic fatty liver disease. Since thermal stability is a desirable factor for therapeutic proteins, we investigated the thermal behavior of human FGF21. FGF21 remai...

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Bibliographic Details
Main Authors: Ye-Eun Jung, Kyeong Won Lee, Jae Hyun Cho, Da-Woon Bae, Bo-Gyeong Jeong, Yeon-Ju Jung, Soo-Bong Park, Young Jun An, Kyungchan Kim, Ga Seul Lee, Lin-Woo Kang, Jeong Hee Moon, Jung-Hyun Lee, Eun-Kyoung Kim, Hyung-Soon Yim, Sun-Shin Cha
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-27717-x

Internet

https://doi.org/10.1038/s41598-023-27717-x

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