Case report: A prosthetic valve endocarditis caused by Legionella bozemanae in an immunocompetent patient
Extrapulmonary infections with Legionella species are rare, but important to acknowledge. We report a case of infective endocarditis (IE) with Legionella bozemanae in a 66-year-old immunocompetent man with an aortic homograft. The diagnosis was made by direct 16S rRNA gene amplification from valve m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1055465/full |
| _version_ | 1811243660807766016 |
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| author | Mai Sasaki Aanensen Fraz Mai Sasaki Aanensen Fraz Mai Sasaki Aanensen Fraz Gry Dahle Kirsten Margrete Skaug Sophie Jarraud Stephan Frye Jørgen Vildershøj Bjørnholt Jørgen Vildershøj Bjørnholt Ingvild Nordøy Ingvild Nordøy |
| author_facet | Mai Sasaki Aanensen Fraz Mai Sasaki Aanensen Fraz Mai Sasaki Aanensen Fraz Gry Dahle Kirsten Margrete Skaug Sophie Jarraud Stephan Frye Jørgen Vildershøj Bjørnholt Jørgen Vildershøj Bjørnholt Ingvild Nordøy Ingvild Nordøy |
| author_sort | Mai Sasaki Aanensen Fraz |
| collection | DOAJ |
| description | Extrapulmonary infections with Legionella species are rare, but important to acknowledge. We report a case of infective endocarditis (IE) with Legionella bozemanae in a 66-year-old immunocompetent man with an aortic homograft. The diagnosis was made by direct 16S rRNA gene amplification from valve material, confirmed by a targeted Legionella-PCR in serum and the detection of L. bozemanae specific antibodies. To our knowledge, this is the first confirmed case of IE with L. bozemanae as causative pathogen. The infected aortic prosthesis was replaced by a homograft, and the patient was successfully treated with levofloxacin and azithromycin for 6 weeks. |
| first_indexed | 2024-04-12T14:11:23Z |
| format | Article |
| id | doaj.art-cb322f905c744caa9d05349a484a14f9 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-12T14:11:23Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-cb322f905c744caa9d05349a484a14f92022-12-22T03:29:52ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-11-01910.3389/fmed.2022.10554651055465Case report: A prosthetic valve endocarditis caused by Legionella bozemanae in an immunocompetent patientMai Sasaki Aanensen Fraz0Mai Sasaki Aanensen Fraz1Mai Sasaki Aanensen Fraz2Gry Dahle3Kirsten Margrete Skaug4Sophie Jarraud5Stephan Frye6Jørgen Vildershøj Bjørnholt7Jørgen Vildershøj Bjørnholt8Ingvild Nordøy9Ingvild Nordøy10Department of Microbiology, Oslo University Hospital, Oslo, NorwayCentre for Rare Disorders, Oslo University Hospital, Oslo, NorwayDepartment of Medicine, Lovisenberg Diaconal Hospital, Oslo, NorwayDepartment of Cardiothoracic Surgery, Oslo University Hospital, Oslo, NorwayDepartment of Microbiology, Oslo University Hospital, Oslo, NorwayNational Reference Centre for Legionella, Institute of Infectious Agents, Hospices Civils de Lyon, Lyon, FranceDepartment of Microbiology, Oslo University Hospital, Oslo, NorwayDepartment of Microbiology, Oslo University Hospital, Oslo, NorwayFaculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, NorwaySection for Clinical Immunology and Infectious Diseases, Oslo University Hospital, Oslo, NorwayResearch Institute of Internal Medicine, Oslo University Hospital, Oslo, NorwayExtrapulmonary infections with Legionella species are rare, but important to acknowledge. We report a case of infective endocarditis (IE) with Legionella bozemanae in a 66-year-old immunocompetent man with an aortic homograft. The diagnosis was made by direct 16S rRNA gene amplification from valve material, confirmed by a targeted Legionella-PCR in serum and the detection of L. bozemanae specific antibodies. To our knowledge, this is the first confirmed case of IE with L. bozemanae as causative pathogen. The infected aortic prosthesis was replaced by a homograft, and the patient was successfully treated with levofloxacin and azithromycin for 6 weeks.https://www.frontiersin.org/articles/10.3389/fmed.2022.1055465/fullendocarditisprosthetic valve endocarditis (PVE)molecular diagnostic techniquesblood culture negative endocarditisLegionella bozemanaeLegionella bozemanii |
| spellingShingle | Mai Sasaki Aanensen Fraz Mai Sasaki Aanensen Fraz Mai Sasaki Aanensen Fraz Gry Dahle Kirsten Margrete Skaug Sophie Jarraud Stephan Frye Jørgen Vildershøj Bjørnholt Jørgen Vildershøj Bjørnholt Ingvild Nordøy Ingvild Nordøy Case report: A prosthetic valve endocarditis caused by Legionella bozemanae in an immunocompetent patient Frontiers in Medicine endocarditis prosthetic valve endocarditis (PVE) molecular diagnostic techniques blood culture negative endocarditis Legionella bozemanae Legionella bozemanii |
| title | Case report: A prosthetic valve endocarditis caused by Legionella bozemanae in an immunocompetent patient |
| title_full | Case report: A prosthetic valve endocarditis caused by Legionella bozemanae in an immunocompetent patient |
| title_fullStr | Case report: A prosthetic valve endocarditis caused by Legionella bozemanae in an immunocompetent patient |
| title_full_unstemmed | Case report: A prosthetic valve endocarditis caused by Legionella bozemanae in an immunocompetent patient |
| title_short | Case report: A prosthetic valve endocarditis caused by Legionella bozemanae in an immunocompetent patient |
| title_sort | case report a prosthetic valve endocarditis caused by legionella bozemanae in an immunocompetent patient |
| topic | endocarditis prosthetic valve endocarditis (PVE) molecular diagnostic techniques blood culture negative endocarditis Legionella bozemanae Legionella bozemanii |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1055465/full |
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