Combination of Epidural Blockade and Parecoxib in Enhanced Recovery After Gastrointestinal Surgery
Objective To investigation effects of the combination use of epidural blockade and parecoxib in postoperative recovery of colorectal cancer (CRC) patients. Methods The present prospective single-blinded study included 186 CRC patients who received radical resection during April 2016 to December 2017...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-08-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2019.1690601 |
| _version_ | 1797684700363358208 |
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| author | Xuerong Zhang Jun Zhu Bingqian Ye Ayibuta Yashengaili Lei Xu Xuebin Li |
| author_facet | Xuerong Zhang Jun Zhu Bingqian Ye Ayibuta Yashengaili Lei Xu Xuebin Li |
| author_sort | Xuerong Zhang |
| collection | DOAJ |
| description | Objective To investigation effects of the combination use of epidural blockade and parecoxib in postoperative recovery of colorectal cancer (CRC) patients. Methods The present prospective single-blinded study included 186 CRC patients who received radical resection during April 2016 to December 2017. All patients were randomized into 3 different groups, the epidural blockade group, the combined-group with both epidural blockade and pre-intravenous injection of parecoxib, and the control group. The mean operative time, bleeding volume, the first out of bed activity time and hospital stay time were recorded. The mini-mental state examination (MMSE) score and Ramsay score were measured for cognitive function and the Visual Analog Score (VAS) was determined for the pain condition. Results The surgery time for the control group was significantly shorter than the other 2 groups (P < 0.05). The VAS scores were significantly lower in both the combined group and the epidural blockade group when compared with the control group and were dramatically lower in the combined group than the others 2 groups (all P < 0.05). The first out of bed activity time and hospital stay time were the shortest in the combined group, and the control group had the longest time (all P < 0.05). Both the Ramsay and MMSE scores were the highest in the combination group than other groups (all P < 0.05) and no significant difference was observed between the epidural blockade group and the control. Conclusion The combination of epidural blockade and parecoxib could enhance the recovery process, as well as reduce the pain for the CRC patients. |
| first_indexed | 2024-03-12T00:33:31Z |
| format | Article |
| id | doaj.art-cb323da9bd014f689e5e950fa4b519b6 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:33:31Z |
| publishDate | 2021-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-cb323da9bd014f689e5e950fa4b519b62023-09-15T10:07:31ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532021-08-0134771672010.1080/08941939.2019.16906011690601Combination of Epidural Blockade and Parecoxib in Enhanced Recovery After Gastrointestinal SurgeryXuerong Zhang0Jun Zhu1Bingqian Ye2Ayibuta Yashengaili3Lei Xu4Xuebin Li5Department of Anesthesiology, People's Hospital of Xinjiang Uygur Autonomous RegionDepartment of Clinic, People's Hospital of Xinjiang Uygur Autonomous RegionXinjiang Medical UniversityXinjiang Medical UniversityXinjiang Medical UniversityDepartment of Anesthesiology, People's Hospital of Xinjiang Uygur Autonomous RegionObjective To investigation effects of the combination use of epidural blockade and parecoxib in postoperative recovery of colorectal cancer (CRC) patients. Methods The present prospective single-blinded study included 186 CRC patients who received radical resection during April 2016 to December 2017. All patients were randomized into 3 different groups, the epidural blockade group, the combined-group with both epidural blockade and pre-intravenous injection of parecoxib, and the control group. The mean operative time, bleeding volume, the first out of bed activity time and hospital stay time were recorded. The mini-mental state examination (MMSE) score and Ramsay score were measured for cognitive function and the Visual Analog Score (VAS) was determined for the pain condition. Results The surgery time for the control group was significantly shorter than the other 2 groups (P < 0.05). The VAS scores were significantly lower in both the combined group and the epidural blockade group when compared with the control group and were dramatically lower in the combined group than the others 2 groups (all P < 0.05). The first out of bed activity time and hospital stay time were the shortest in the combined group, and the control group had the longest time (all P < 0.05). Both the Ramsay and MMSE scores were the highest in the combination group than other groups (all P < 0.05) and no significant difference was observed between the epidural blockade group and the control. Conclusion The combination of epidural blockade and parecoxib could enhance the recovery process, as well as reduce the pain for the CRC patients.http://dx.doi.org/10.1080/08941939.2019.1690601colorectal cancerepidural blockadeparecoxibenhanced recovery |
| spellingShingle | Xuerong Zhang Jun Zhu Bingqian Ye Ayibuta Yashengaili Lei Xu Xuebin Li Combination of Epidural Blockade and Parecoxib in Enhanced Recovery After Gastrointestinal Surgery Journal of Investigative Surgery colorectal cancer epidural blockade parecoxib enhanced recovery |
| title | Combination of Epidural Blockade and Parecoxib in Enhanced Recovery After Gastrointestinal Surgery |
| title_full | Combination of Epidural Blockade and Parecoxib in Enhanced Recovery After Gastrointestinal Surgery |
| title_fullStr | Combination of Epidural Blockade and Parecoxib in Enhanced Recovery After Gastrointestinal Surgery |
| title_full_unstemmed | Combination of Epidural Blockade and Parecoxib in Enhanced Recovery After Gastrointestinal Surgery |
| title_short | Combination of Epidural Blockade and Parecoxib in Enhanced Recovery After Gastrointestinal Surgery |
| title_sort | combination of epidural blockade and parecoxib in enhanced recovery after gastrointestinal surgery |
| topic | colorectal cancer epidural blockade parecoxib enhanced recovery |
| url | http://dx.doi.org/10.1080/08941939.2019.1690601 |
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