Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy
Abstract Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings. Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia. Dynamin-related protein 1 (Drp1) regulates mitochondrial quality and cellular functions via its oligomeric change...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Military Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40779-023-00482-8 |
| _version_ | 1797453502208802816 |
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| author | Shuai Hao He Huang Rui-Yan Ma Xue Zeng Chen-Yang Duan |
| author_facet | Shuai Hao He Huang Rui-Yan Ma Xue Zeng Chen-Yang Duan |
| author_sort | Shuai Hao |
| collection | DOAJ |
| description | Abstract Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings. Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia. Dynamin-related protein 1 (Drp1) regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications, which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic injury. However, there is active controversy and gaps in knowledge regarding the modification, protein interaction, and functions of Drp1, which both hinder and promote development of Drp1 as a novel therapeutic target. Here, we summarize recent findings on the oligomeric changes, modification types, and protein interactions of Drp1 in various hypoxic-ischemic diseases, as well as the Drp1-mediated regulation of mitochondrial quality and cell functions following ischemia and hypoxia. Additionally, potential clinical translation prospects for targeting Drp1 are discussed. This review provides new ideas and targets for proactive interventions on multiple organ damage induced by various hypoxic-ischemic diseases. |
| first_indexed | 2024-03-09T15:23:46Z |
| format | Article |
| id | doaj.art-cb36bd9424824ceda312bb1b64dc23d8 |
| institution | Directory Open Access Journal |
| issn | 2054-9369 |
| language | English |
| last_indexed | 2024-03-09T15:23:46Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Military Medical Research |
| spelling | doaj.art-cb36bd9424824ceda312bb1b64dc23d82023-11-26T12:40:59ZengBMCMilitary Medical Research2054-93692023-10-0110112710.1186/s40779-023-00482-8Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategyShuai Hao0He Huang1Rui-Yan Ma2Xue Zeng3Chen-Yang Duan4Department of Anesthesiology, the Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Anesthesiology, the Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Anesthesiology, the Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Anesthesiology, the Second Affiliated Hospital of Chongqing Medical UniversityDepartment of Anesthesiology, the Second Affiliated Hospital of Chongqing Medical UniversityAbstract Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings. Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia. Dynamin-related protein 1 (Drp1) regulates mitochondrial quality and cellular functions via its oligomeric changes and multiple modifications, which plays a role in mediating the induction of multiple organ damage during hypoxic-ischemic injury. However, there is active controversy and gaps in knowledge regarding the modification, protein interaction, and functions of Drp1, which both hinder and promote development of Drp1 as a novel therapeutic target. Here, we summarize recent findings on the oligomeric changes, modification types, and protein interactions of Drp1 in various hypoxic-ischemic diseases, as well as the Drp1-mediated regulation of mitochondrial quality and cell functions following ischemia and hypoxia. Additionally, potential clinical translation prospects for targeting Drp1 are discussed. This review provides new ideas and targets for proactive interventions on multiple organ damage induced by various hypoxic-ischemic diseases.https://doi.org/10.1186/s40779-023-00482-8Dynamin-related protein 1 (Drp1)Hypoxic-ischemic injuryMitochondrial quality imbalanceCell dysfunctionOrgan damage |
| spellingShingle | Shuai Hao He Huang Rui-Yan Ma Xue Zeng Chen-Yang Duan Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy Military Medical Research Dynamin-related protein 1 (Drp1) Hypoxic-ischemic injury Mitochondrial quality imbalance Cell dysfunction Organ damage |
| title | Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy |
| title_full | Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy |
| title_fullStr | Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy |
| title_full_unstemmed | Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy |
| title_short | Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy |
| title_sort | multifaceted functions of drp1 in hypoxia ischemia induced mitochondrial quality imbalance from regulatory mechanism to targeted therapeutic strategy |
| topic | Dynamin-related protein 1 (Drp1) Hypoxic-ischemic injury Mitochondrial quality imbalance Cell dysfunction Organ damage |
| url | https://doi.org/10.1186/s40779-023-00482-8 |
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