Indistinguishable pattern of amygdala and hippocampus rewiring following tone or contextual fear conditioning in C57BL/6 mice
Changes in neuronal connectivity occurring upon the formation of aversive memory were examined in C57BL/6 (C57) mice 24h after they were trained for tone and contextual fear conditioning (TFC and CFC). Although TFC and CFC are amenable to distinct learning systems each involving a specific neural su...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-10-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00156/full |
| _version_ | 1811230140759277568 |
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| author | Annabella ePignataro Silvia eMiddei Silvia eMiddei Antonella eBorreca Martine eAmmassari-Teule Martine eAmmassari-Teule |
| author_facet | Annabella ePignataro Silvia eMiddei Silvia eMiddei Antonella eBorreca Martine eAmmassari-Teule Martine eAmmassari-Teule |
| author_sort | Annabella ePignataro |
| collection | DOAJ |
| description | Changes in neuronal connectivity occurring upon the formation of aversive memory were examined in C57BL/6 (C57) mice 24h after they were trained for tone and contextual fear conditioning (TFC and CFC). Although TFC and CFC are amenable to distinct learning systems each involving a specific neural substrate, we found that mice trained in the two protocols showed the same increase in spine density and spine size in class I basolateral amygdala and in dorsal hippocampus CA1 pyramidal neurons. Our findings suggest that, because of their remarkably functional hippocampus, C57 mice might engage this region in any fear situation they face. These observations raise a point relevant to aversive memory studies, i.e., how the peculiarity of memory in certain individuals impacts on the components of the fear circuitry. It is suggested that enhanced connectivity in brain regions dispensable for specific forms of learning could considerably increase the resistance of aversive memory traces to treatments aimed at disrupting them. |
| first_indexed | 2024-04-12T10:25:18Z |
| format | Article |
| id | doaj.art-cb37b5aaef5a4956986e2e4b6ab3df26 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-12T10:25:18Z |
| publishDate | 2013-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-cb37b5aaef5a4956986e2e4b6ab3df262022-12-22T03:37:00ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532013-10-01710.3389/fnbeh.2013.0015662218Indistinguishable pattern of amygdala and hippocampus rewiring following tone or contextual fear conditioning in C57BL/6 miceAnnabella ePignataro0Silvia eMiddei1Silvia eMiddei2Antonella eBorreca3Martine eAmmassari-Teule4Martine eAmmassari-Teule5Santa Lucia FoundationSanta Lucia FoundationNational Research CouncilSanta Lucia FoundationSanta Lucia FoundationNational Research CouncilChanges in neuronal connectivity occurring upon the formation of aversive memory were examined in C57BL/6 (C57) mice 24h after they were trained for tone and contextual fear conditioning (TFC and CFC). Although TFC and CFC are amenable to distinct learning systems each involving a specific neural substrate, we found that mice trained in the two protocols showed the same increase in spine density and spine size in class I basolateral amygdala and in dorsal hippocampus CA1 pyramidal neurons. Our findings suggest that, because of their remarkably functional hippocampus, C57 mice might engage this region in any fear situation they face. These observations raise a point relevant to aversive memory studies, i.e., how the peculiarity of memory in certain individuals impacts on the components of the fear circuitry. It is suggested that enhanced connectivity in brain regions dispensable for specific forms of learning could considerably increase the resistance of aversive memory traces to treatments aimed at disrupting them.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00156/fullAmygdalaDendritic SpinesHippocampuscontextual fear conditioningTone Fear ConditioningSpine morphology |
| spellingShingle | Annabella ePignataro Silvia eMiddei Silvia eMiddei Antonella eBorreca Martine eAmmassari-Teule Martine eAmmassari-Teule Indistinguishable pattern of amygdala and hippocampus rewiring following tone or contextual fear conditioning in C57BL/6 mice Frontiers in Behavioral Neuroscience Amygdala Dendritic Spines Hippocampus contextual fear conditioning Tone Fear Conditioning Spine morphology |
| title | Indistinguishable pattern of amygdala and hippocampus rewiring following tone or contextual fear conditioning in C57BL/6 mice |
| title_full | Indistinguishable pattern of amygdala and hippocampus rewiring following tone or contextual fear conditioning in C57BL/6 mice |
| title_fullStr | Indistinguishable pattern of amygdala and hippocampus rewiring following tone or contextual fear conditioning in C57BL/6 mice |
| title_full_unstemmed | Indistinguishable pattern of amygdala and hippocampus rewiring following tone or contextual fear conditioning in C57BL/6 mice |
| title_short | Indistinguishable pattern of amygdala and hippocampus rewiring following tone or contextual fear conditioning in C57BL/6 mice |
| title_sort | indistinguishable pattern of amygdala and hippocampus rewiring following tone or contextual fear conditioning in c57bl 6 mice |
| topic | Amygdala Dendritic Spines Hippocampus contextual fear conditioning Tone Fear Conditioning Spine morphology |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00156/full |
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