Two-dimensional-quantitative structure-activity relationship studies of a novel series of diaryl furanone derivatives: An approach to design selective and effective cyclooxygenase-2 inhibitors

Two-dimensional-quantitative structure-activity relationship studies of a novel series of diaryl furanone derivatives: An approach to design selective and effective cyclooxygenase-2 inhibitors

INTRODUCTION: Over a decade, a large number of selective cyclooxygenase-2 (COX-2) inhibitors with diverse chemical characteristics have been designed but only a few have emerged as drugs. MATERIALS AND METHODS: In the present study, two-dimensional-quantitative structure-activity relationship (2D-QS...

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Bibliographic Details
Main Authors: Manjula K Chikkamath, Pratibha M Huded, Swetha S Kokatnur, Akshata S Menasinakai, Mahesh B Palkar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Indian Journal of Health Sciences and Biomedical Research KLEU
Subjects:
Cyclooxygenase
diaryl furanone
multiple linear regression
partial least squares regression
quantitative structure-activity relationship
Online Access:http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2018;volume=11;issue=1;spage=28;epage=41;aulast=Chikkamath

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