Garlicnin B1, an Active Cyclic Sulfide from Garlic, Exhibits Potent Anti-Inflammatory and Anti-Tumor Activities
This study aimed to investigate the pharmacological activities of garlicnin B1, a cyclic sulfide compound found abundantly in garlic and structurally similar to onionin A1, which has been shown to possess strong anti-tumor effects. In vitro studies demonstrated that garlicnin B1 significantly reduce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/4/869 |
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| author | Shanghui Gao Kai Yang Toshihiro Nohara Tsuyoshi Ikeda Jian-Rong Zhou Kazumi Yokomizo Jun Fang |
| author_facet | Shanghui Gao Kai Yang Toshihiro Nohara Tsuyoshi Ikeda Jian-Rong Zhou Kazumi Yokomizo Jun Fang |
| author_sort | Shanghui Gao |
| collection | DOAJ |
| description | This study aimed to investigate the pharmacological activities of garlicnin B1, a cyclic sulfide compound found abundantly in garlic and structurally similar to onionin A1, which has been shown to possess strong anti-tumor effects. In vitro studies demonstrated that garlicnin B1 significantly reduced intracellular reactive oxygen species triggered by hydrogen peroxide in colon cancer cells. In a mouse colitis model induced by dextran sulfate sodium, garlicnin B1 at a low dose (5 mg/kg) remarkably ameliorated the symptoms and pathological progression. Additionally, garlicnin B1 exhibited considerable tumoricidal activity with an IC50 value of ~20 μM, as observed in cytotoxicity assays. In vivo experiments using the mouse sarcoma S180 transplanted model and the azoxymethane (AOM) or DSS-induced colon cancer model showed that garlicnin B1 effectively suppressed tumor growth in a dose-dependent manner, with marked inhibition at 80 mg/kg. These results suggest that garlicnin B1 has diverse functions that could be achieved by carefully manipulating the dosing regimen. We anticipate that garlicnin B1 has the potential to be used beneficially in the future for the treatment of cancer and inflammatory diseases, although further studies are warranted to elucidate its mechanisms of action. |
| first_indexed | 2024-03-11T05:18:21Z |
| format | Article |
| id | doaj.art-cb3935d2aa85460e86ccc91ab9424875 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T05:18:21Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-cb3935d2aa85460e86ccc91ab94248752023-11-17T18:05:30ZengMDPI AGAntioxidants2076-39212023-04-0112486910.3390/antiox12040869Garlicnin B1, an Active Cyclic Sulfide from Garlic, Exhibits Potent Anti-Inflammatory and Anti-Tumor ActivitiesShanghui Gao0Kai Yang1Toshihiro Nohara2Tsuyoshi Ikeda3Jian-Rong Zhou4Kazumi Yokomizo5Jun Fang6Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, JapanFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, JapanFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, JapanFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, JapanFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, JapanFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, JapanFaculty of Pharmaceutical Sciences, Sojo University, Kumamoto 860-0082, JapanThis study aimed to investigate the pharmacological activities of garlicnin B1, a cyclic sulfide compound found abundantly in garlic and structurally similar to onionin A1, which has been shown to possess strong anti-tumor effects. In vitro studies demonstrated that garlicnin B1 significantly reduced intracellular reactive oxygen species triggered by hydrogen peroxide in colon cancer cells. In a mouse colitis model induced by dextran sulfate sodium, garlicnin B1 at a low dose (5 mg/kg) remarkably ameliorated the symptoms and pathological progression. Additionally, garlicnin B1 exhibited considerable tumoricidal activity with an IC50 value of ~20 μM, as observed in cytotoxicity assays. In vivo experiments using the mouse sarcoma S180 transplanted model and the azoxymethane (AOM) or DSS-induced colon cancer model showed that garlicnin B1 effectively suppressed tumor growth in a dose-dependent manner, with marked inhibition at 80 mg/kg. These results suggest that garlicnin B1 has diverse functions that could be achieved by carefully manipulating the dosing regimen. We anticipate that garlicnin B1 has the potential to be used beneficially in the future for the treatment of cancer and inflammatory diseases, although further studies are warranted to elucidate its mechanisms of action.https://www.mdpi.com/2076-3921/12/4/869garlicnin B1anti-inflammationanti-cancernatural productsreactive oxygen species |
| spellingShingle | Shanghui Gao Kai Yang Toshihiro Nohara Tsuyoshi Ikeda Jian-Rong Zhou Kazumi Yokomizo Jun Fang Garlicnin B1, an Active Cyclic Sulfide from Garlic, Exhibits Potent Anti-Inflammatory and Anti-Tumor Activities Antioxidants garlicnin B1 anti-inflammation anti-cancer natural products reactive oxygen species |
| title | Garlicnin B1, an Active Cyclic Sulfide from Garlic, Exhibits Potent Anti-Inflammatory and Anti-Tumor Activities |
| title_full | Garlicnin B1, an Active Cyclic Sulfide from Garlic, Exhibits Potent Anti-Inflammatory and Anti-Tumor Activities |
| title_fullStr | Garlicnin B1, an Active Cyclic Sulfide from Garlic, Exhibits Potent Anti-Inflammatory and Anti-Tumor Activities |
| title_full_unstemmed | Garlicnin B1, an Active Cyclic Sulfide from Garlic, Exhibits Potent Anti-Inflammatory and Anti-Tumor Activities |
| title_short | Garlicnin B1, an Active Cyclic Sulfide from Garlic, Exhibits Potent Anti-Inflammatory and Anti-Tumor Activities |
| title_sort | garlicnin b1 an active cyclic sulfide from garlic exhibits potent anti inflammatory and anti tumor activities |
| topic | garlicnin B1 anti-inflammation anti-cancer natural products reactive oxygen species |
| url | https://www.mdpi.com/2076-3921/12/4/869 |
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