The correlation between albuminuria and cystatin C in the assessment of the kidney function in patients with type 2 diabetes mellitus
Introduction: Cystatin C has shown a better correlation with albuminuria in relation to creatinine. It filters in glomeruli, reabsorbs in tubules, and does not go back into circulation, which makes it a reliable parameter for the assessment of kidney function. Aim of the study: To determine albuminu...
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| Format: | Article |
| Language: | English |
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2015-01-01
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| Series: | Scripta Medica |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2015/0350-82181502098R.pdf |
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| author | Risović Ivona Popović-Pejičić Snježana Vlatković Vlastimir |
| author_facet | Risović Ivona Popović-Pejičić Snježana Vlatković Vlastimir |
| author_sort | Risović Ivona |
| collection | DOAJ |
| description | Introduction: Cystatin C has shown a better correlation with albuminuria in relation to creatinine. It filters in glomeruli, reabsorbs in tubules, and does not go back into circulation, which makes it a reliable parameter for the assessment of kidney function. Aim of the study: To determine albuminuria and serum cystatin C in patients with type 2 diabetes mellitus (DM) and to examine the correlation between these two parameters depending on the degree of albuminuria. Patients and Methods: Forty-seven patients with type 2 DM were divided in three groups: Group I-25 patients with albuminuria < 30 mg/24 hours, Group II-15 patients with albuminuria of 30-299 mg/24 hours and Group III -7 patients with albuminuria > 300 mg/24 hours. For the purpose of assessing the kidney function, cystatin C and creatinine in the serum were determined and the glomerular filtration rate (GFR) was calculated. Results: Higher degrees of albuminuria were associated with longer duration of disease, poorer regulation of glycaemia and blood pressure and kidney damage. The mean values of cystatin C were increased with the degree of albuminuria: 0.99(0,7- 1,25;IQ) vs. 1.18(1,05-1,36;IQ) vs.1.74(1,45-2,01;IQ) mg/l. Cystatin C has shown a statistically significant direct correlation with the albuminuria, especially in the third group (r= 0.82, p <0.001). Conclusion: In this research, cystatin C has shown a good correlation with albuminuria. The values of cystatin C were associated with the changes in the values of albuminuria. |
| first_indexed | 2024-12-13T08:01:35Z |
| format | Article |
| id | doaj.art-cb39b570293347d4a8f092e906600407 |
| institution | Directory Open Access Journal |
| issn | 2490-3329 2303-7954 |
| language | English |
| last_indexed | 2024-12-13T08:01:35Z |
| publishDate | 2015-01-01 |
| publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
| record_format | Article |
| series | Scripta Medica |
| spelling | doaj.art-cb39b570293347d4a8f092e9066004072022-12-21T23:54:25ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542015-01-01462981020350-82181502098RThe correlation between albuminuria and cystatin C in the assessment of the kidney function in patients with type 2 diabetes mellitusRisović Ivona0Popović-Pejičić Snježana1Vlatković Vlastimir2International Dialysis Centre, Laktaši, Bosnia and HerzegovinaUniversity Hospital -Clinical Centre, Banja Luka, Bosnia and HerzegovinaUniversity Hospital -Clinical Centre, Banja Luka, Bosnia and HerzegovinaIntroduction: Cystatin C has shown a better correlation with albuminuria in relation to creatinine. It filters in glomeruli, reabsorbs in tubules, and does not go back into circulation, which makes it a reliable parameter for the assessment of kidney function. Aim of the study: To determine albuminuria and serum cystatin C in patients with type 2 diabetes mellitus (DM) and to examine the correlation between these two parameters depending on the degree of albuminuria. Patients and Methods: Forty-seven patients with type 2 DM were divided in three groups: Group I-25 patients with albuminuria < 30 mg/24 hours, Group II-15 patients with albuminuria of 30-299 mg/24 hours and Group III -7 patients with albuminuria > 300 mg/24 hours. For the purpose of assessing the kidney function, cystatin C and creatinine in the serum were determined and the glomerular filtration rate (GFR) was calculated. Results: Higher degrees of albuminuria were associated with longer duration of disease, poorer regulation of glycaemia and blood pressure and kidney damage. The mean values of cystatin C were increased with the degree of albuminuria: 0.99(0,7- 1,25;IQ) vs. 1.18(1,05-1,36;IQ) vs.1.74(1,45-2,01;IQ) mg/l. Cystatin C has shown a statistically significant direct correlation with the albuminuria, especially in the third group (r= 0.82, p <0.001). Conclusion: In this research, cystatin C has shown a good correlation with albuminuria. The values of cystatin C were associated with the changes in the values of albuminuria.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2015/0350-82181502098R.pdfdiabetes mellituscystatin calbuminuria |
| spellingShingle | Risović Ivona Popović-Pejičić Snježana Vlatković Vlastimir The correlation between albuminuria and cystatin C in the assessment of the kidney function in patients with type 2 diabetes mellitus Scripta Medica diabetes mellitus cystatin c albuminuria |
| title | The correlation between albuminuria and cystatin C in the assessment of the kidney function in patients with type 2 diabetes mellitus |
| title_full | The correlation between albuminuria and cystatin C in the assessment of the kidney function in patients with type 2 diabetes mellitus |
| title_fullStr | The correlation between albuminuria and cystatin C in the assessment of the kidney function in patients with type 2 diabetes mellitus |
| title_full_unstemmed | The correlation between albuminuria and cystatin C in the assessment of the kidney function in patients with type 2 diabetes mellitus |
| title_short | The correlation between albuminuria and cystatin C in the assessment of the kidney function in patients with type 2 diabetes mellitus |
| title_sort | correlation between albuminuria and cystatin c in the assessment of the kidney function in patients with type 2 diabetes mellitus |
| topic | diabetes mellitus cystatin c albuminuria |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2015/0350-82181502098R.pdf |
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