Altered gray matter volume and functional connectivity in medial orbitofrontal cortex of bulimia nervosa patients: A combined VBM and FC study
Brain structural and functional abnormalities have been shown to be involved in the neurobiological underpinnings of bulimia nervosa (BN), while the mechanisms underlying this dysregulation are unclear. The main goal of this investigation was to explore the presence of brain structural alterations a...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.963092/full |
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| author | Wei-hua Li Li-rong Tang Li-rong Tang Miao Wang Jia-ni Wang Ting Guo Ting Guo Qiong He Qiong He Yu-yang He Yu-yang He Zi-ling Lv Zi-ling Lv Qian Chen Zheng Wang Xiao-hong Li Xiao-hong Li Peng Zhang Zhan-jiang Li Zhan-jiang Li Zhen-chang Wang |
| author_facet | Wei-hua Li Li-rong Tang Li-rong Tang Miao Wang Jia-ni Wang Ting Guo Ting Guo Qiong He Qiong He Yu-yang He Yu-yang He Zi-ling Lv Zi-ling Lv Qian Chen Zheng Wang Xiao-hong Li Xiao-hong Li Peng Zhang Zhan-jiang Li Zhan-jiang Li Zhen-chang Wang |
| author_sort | Wei-hua Li |
| collection | DOAJ |
| description | Brain structural and functional abnormalities have been shown to be involved in the neurobiological underpinnings of bulimia nervosa (BN), while the mechanisms underlying this dysregulation are unclear. The main goal of this investigation was to explore the presence of brain structural alterations and relevant functional changes in BN. We hypothesized that BN patients had regional gray matter volume abnormalities and corresponding resting-state functional connectivity (rsFC) changes compared with healthy controls. Thirty-one BN patients and twenty-eight matched healthy controls underwent both high-resolution T1-weighted magnetic resonance imaging (MRI) and resting-state functional MRI. Structural analysis was performed by voxel-based morphometry (VBM), with subsequent rsFC analysis applied by a seed-based, whole-brain voxelwise approach using the abnormal gray matter volume (GMV) region of interest as the seed. Compared with the controls, the BN patients showed increased GMV in the left medial orbitofrontal cortex (mOFC). The BN patients also exhibited significantly increased rsFC between the left mOFC and the right superior occipital gyrus (SOG) and decreased rsFC between the left mOFC and the left precentral gyrus, postcentral gyrus, and supplementary motor area (SMA). Furthermore, the z values of rsFC between the left mOFC and right SOG was positively correlated with the Dutch Eating Behavior Questionnaire-external eating scores. Findings from this investigation further suggest that the mOFC plays a crucial role in the neural pathophysiological underpinnings of BN, which may lead to sensorimotor and visual regions reorganization and be related to representations of body image and the drive behind eating behavior. These findings have important implications for understanding neural mechanisms in BN and developing strategies for prevention. |
| first_indexed | 2024-04-11T22:33:20Z |
| format | Article |
| id | doaj.art-cb3a2fb513eb494bb27b71013a5b8ed3 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-11T22:33:20Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-cb3a2fb513eb494bb27b71013a5b8ed32022-12-22T03:59:18ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-08-011310.3389/fpsyt.2022.963092963092Altered gray matter volume and functional connectivity in medial orbitofrontal cortex of bulimia nervosa patients: A combined VBM and FC studyWei-hua Li0Li-rong Tang1Li-rong Tang2Miao Wang3Jia-ni Wang4Ting Guo5Ting Guo6Qiong He7Qiong He8Yu-yang He9Yu-yang He10Zi-ling Lv11Zi-ling Lv12Qian Chen13Zheng Wang14Xiao-hong Li15Xiao-hong Li16Peng Zhang17Zhan-jiang Li18Zhan-jiang Li19Zhen-chang Wang20Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaBeijing Anding Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing, ChinaChinese Institute for Brain Research, Beijing, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaBeijing Anding Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing, ChinaBeijing Anding Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing, ChinaBeijing Anding Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing, ChinaBeijing Anding Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaBeijing Anding Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaBeijing Anding Hospital, Capital Medical University, Beijing, ChinaThe National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders, Beijing, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaBrain structural and functional abnormalities have been shown to be involved in the neurobiological underpinnings of bulimia nervosa (BN), while the mechanisms underlying this dysregulation are unclear. The main goal of this investigation was to explore the presence of brain structural alterations and relevant functional changes in BN. We hypothesized that BN patients had regional gray matter volume abnormalities and corresponding resting-state functional connectivity (rsFC) changes compared with healthy controls. Thirty-one BN patients and twenty-eight matched healthy controls underwent both high-resolution T1-weighted magnetic resonance imaging (MRI) and resting-state functional MRI. Structural analysis was performed by voxel-based morphometry (VBM), with subsequent rsFC analysis applied by a seed-based, whole-brain voxelwise approach using the abnormal gray matter volume (GMV) region of interest as the seed. Compared with the controls, the BN patients showed increased GMV in the left medial orbitofrontal cortex (mOFC). The BN patients also exhibited significantly increased rsFC between the left mOFC and the right superior occipital gyrus (SOG) and decreased rsFC between the left mOFC and the left precentral gyrus, postcentral gyrus, and supplementary motor area (SMA). Furthermore, the z values of rsFC between the left mOFC and right SOG was positively correlated with the Dutch Eating Behavior Questionnaire-external eating scores. Findings from this investigation further suggest that the mOFC plays a crucial role in the neural pathophysiological underpinnings of BN, which may lead to sensorimotor and visual regions reorganization and be related to representations of body image and the drive behind eating behavior. These findings have important implications for understanding neural mechanisms in BN and developing strategies for prevention.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.963092/fullbulimia nervosaeating disordervoxel-based morphometrystructural MRIresting-state fMRI |
| spellingShingle | Wei-hua Li Li-rong Tang Li-rong Tang Miao Wang Jia-ni Wang Ting Guo Ting Guo Qiong He Qiong He Yu-yang He Yu-yang He Zi-ling Lv Zi-ling Lv Qian Chen Zheng Wang Xiao-hong Li Xiao-hong Li Peng Zhang Zhan-jiang Li Zhan-jiang Li Zhen-chang Wang Altered gray matter volume and functional connectivity in medial orbitofrontal cortex of bulimia nervosa patients: A combined VBM and FC study Frontiers in Psychiatry bulimia nervosa eating disorder voxel-based morphometry structural MRI resting-state fMRI |
| title | Altered gray matter volume and functional connectivity in medial orbitofrontal cortex of bulimia nervosa patients: A combined VBM and FC study |
| title_full | Altered gray matter volume and functional connectivity in medial orbitofrontal cortex of bulimia nervosa patients: A combined VBM and FC study |
| title_fullStr | Altered gray matter volume and functional connectivity in medial orbitofrontal cortex of bulimia nervosa patients: A combined VBM and FC study |
| title_full_unstemmed | Altered gray matter volume and functional connectivity in medial orbitofrontal cortex of bulimia nervosa patients: A combined VBM and FC study |
| title_short | Altered gray matter volume and functional connectivity in medial orbitofrontal cortex of bulimia nervosa patients: A combined VBM and FC study |
| title_sort | altered gray matter volume and functional connectivity in medial orbitofrontal cortex of bulimia nervosa patients a combined vbm and fc study |
| topic | bulimia nervosa eating disorder voxel-based morphometry structural MRI resting-state fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.963092/full |
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