Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and Treatment
In biology, collagen-biomaterial regulates several signaling mechanisms of bone and immune cells involved in tissue repair and any imbalance in collagen turnover may affect the homeostasis of cells, becoming a major cause of several complications. In this case, the administration of oral collagen ma...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/9/7/321 |
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| author | Jeevithan Elango Camilo Zamora-Ledezma Baolin Ge Chunyu Hou Zhilin Pan Bin Bao Carlos Pérez Albacete Martínez José Manuel Granero Marín José Eduardo Maté Sánchez de Val Chunling Bao Wenhui Wu |
| author_facet | Jeevithan Elango Camilo Zamora-Ledezma Baolin Ge Chunyu Hou Zhilin Pan Bin Bao Carlos Pérez Albacete Martínez José Manuel Granero Marín José Eduardo Maté Sánchez de Val Chunling Bao Wenhui Wu |
| author_sort | Jeevithan Elango |
| collection | DOAJ |
| description | In biology, collagen-biomaterial regulates several signaling mechanisms of bone and immune cells involved in tissue repair and any imbalance in collagen turnover may affect the homeostasis of cells, becoming a major cause of several complications. In this case, the administration of oral collagen may play a potential role in returning cells to their normal function. For several decades, the beneficial effects of collagen have been explored widely, and thus many commercial products are available in cosmetics, food, and biomedical fields. For instance, collagen-based-products have been widely used to treat the complications of cartilage-related-disorders. Many researchers are reporting the anti-arthritogenic properties of collagen-based materials. In contrast, collagen, especially type-II collagen (CII), has been widely used to induce arthritis by immunization in an animal-model with or without adjuvants, and the potentially immunogenic-properties of collagen have been continuously reported for a long time. Additionally, the immune tolerance of collagen is mainly regulated by the T-lymphocytes and B-cells. This controversial hypothesis is getting more and more evidence nowadays from both sides to support its mechanism. Therefore, this review links the gap between the arthritogenic and anti-arthritogenic effects of collagen and explored the actual mechanism to understand the fundamental concept of collagen in arthritis. Accordingly, this review opens-up several unrevealed scientific knots of collagen and arthritis and helps the researchers understand the potential use of collagen in therapeutic applications. |
| first_indexed | 2024-03-09T12:15:14Z |
| format | Article |
| id | doaj.art-cb3a54d911534aa68fb6f872ee1debbd |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T12:15:14Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-cb3a54d911534aa68fb6f872ee1debbd2023-11-30T22:48:27ZengMDPI AGBioengineering2306-53542022-07-019732110.3390/bioengineering9070321Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and TreatmentJeevithan Elango0Camilo Zamora-Ledezma1Baolin Ge2Chunyu Hou3Zhilin Pan4Bin Bao5Carlos Pérez Albacete Martínez6José Manuel Granero Marín7José Eduardo Maté Sánchez de Val8Chunling Bao9Wenhui Wu10Department of Biomaterials Engineering, Faculty of Health Sciences, UCAM-Universidad Católica San Antonio de Murcia, Guadalupe, 30107 Murcia, SpainTissue Regeneration and Repair Group, Biomaterials and Tissue Engineering, Faculty of Health Sciences, UCAM-Universidad Católica San Antonio de Murcia, Guadalupe, 30107 Murcia, SpainDepartment of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, ChinaDepartment of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, ChinaDepartment of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, ChinaDepartment of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, ChinaOral Surgery and Oral Implantology Department, UCAM-Universidad Católica San Antonio de Murcia, 30107 Murcia, SpainDepartment of Implant Dentistry, Faculty of Medicine and Dentistry, UCAM-Universidad Católica San Antonio de Murcia, 30107 Murcia, SpainDepartment of Biomaterials Engineering, Faculty of Health Sciences, UCAM-Universidad Católica San Antonio de Murcia, Guadalupe, 30107 Murcia, SpainThe Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 201306, ChinaDepartment of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, ChinaIn biology, collagen-biomaterial regulates several signaling mechanisms of bone and immune cells involved in tissue repair and any imbalance in collagen turnover may affect the homeostasis of cells, becoming a major cause of several complications. In this case, the administration of oral collagen may play a potential role in returning cells to their normal function. For several decades, the beneficial effects of collagen have been explored widely, and thus many commercial products are available in cosmetics, food, and biomedical fields. For instance, collagen-based-products have been widely used to treat the complications of cartilage-related-disorders. Many researchers are reporting the anti-arthritogenic properties of collagen-based materials. In contrast, collagen, especially type-II collagen (CII), has been widely used to induce arthritis by immunization in an animal-model with or without adjuvants, and the potentially immunogenic-properties of collagen have been continuously reported for a long time. Additionally, the immune tolerance of collagen is mainly regulated by the T-lymphocytes and B-cells. This controversial hypothesis is getting more and more evidence nowadays from both sides to support its mechanism. Therefore, this review links the gap between the arthritogenic and anti-arthritogenic effects of collagen and explored the actual mechanism to understand the fundamental concept of collagen in arthritis. Accordingly, this review opens-up several unrevealed scientific knots of collagen and arthritis and helps the researchers understand the potential use of collagen in therapeutic applications.https://www.mdpi.com/2306-5354/9/7/321collagencollagen peptidearthritisjoint treatmentmechanismhomeostasis |
| spellingShingle | Jeevithan Elango Camilo Zamora-Ledezma Baolin Ge Chunyu Hou Zhilin Pan Bin Bao Carlos Pérez Albacete Martínez José Manuel Granero Marín José Eduardo Maté Sánchez de Val Chunling Bao Wenhui Wu Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and Treatment Bioengineering collagen collagen peptide arthritis joint treatment mechanism homeostasis |
| title | Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and Treatment |
| title_full | Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and Treatment |
| title_fullStr | Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and Treatment |
| title_full_unstemmed | Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and Treatment |
| title_short | Paradoxical Duel Role of Collagen in Rheumatoid Arthritis: Cause of Inflammation and Treatment |
| title_sort | paradoxical duel role of collagen in rheumatoid arthritis cause of inflammation and treatment |
| topic | collagen collagen peptide arthritis joint treatment mechanism homeostasis |
| url | https://www.mdpi.com/2306-5354/9/7/321 |
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