Fear conditioning induced by interpersonal conflicts in healthy individuals.
Psychophysiological markers have been focused to investigate the psychopathology of psychiatric disorders and personality subtypes. In order to understand neurobiological mechanisms underlying these conditions, fear-conditioning model has been widely used. However, simple aversive stimuli are too si...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4433209?pdf=render |
| _version_ | 1819024569728499712 |
|---|---|
| author | Mitsuhiro Tada Hiroyuki Uchida Takaki Maeda Mika Konishi Satoshi Umeda Yuri Terasawa Shinichiro Nakajima Masaru Mimura Tomoyuki Miyazaki Takuya Takahashi |
| author_facet | Mitsuhiro Tada Hiroyuki Uchida Takaki Maeda Mika Konishi Satoshi Umeda Yuri Terasawa Shinichiro Nakajima Masaru Mimura Tomoyuki Miyazaki Takuya Takahashi |
| author_sort | Mitsuhiro Tada |
| collection | DOAJ |
| description | Psychophysiological markers have been focused to investigate the psychopathology of psychiatric disorders and personality subtypes. In order to understand neurobiological mechanisms underlying these conditions, fear-conditioning model has been widely used. However, simple aversive stimuli are too simplistic to understand mechanisms because most patients with psychiatric disorders are affected by social stressors. The objective of this study was to test the feasibility of a newly-designed conditioning experiment using a stimulus to cause interpersonal conflicts and examine associations between personality traits and response to that stimulus. Twenty-nine healthy individuals underwent the fear conditioning and extinction experiments in response to three types of stimuli: a simple aversive sound, disgusting pictures, and pictures of an actors' face with unpleasant verbal messages that were designed to cause interpersonal conflicts. Conditioned response was quantified by the skin conductance response (SCR). Correlations between the SCR changes, and personality traits measured by the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) and Revised NEO Personality Inventory were explored. The interpersonal conflict stimulus resulted in successful conditioning, which was subsequently extinguished, in a similar manner as the other two stimuli. Moreover, a greater degree of conditioned response to the interpersonal conflict stimulus correlated with a higher ZAN-BPD total score. Fear conditioning and extinction can be successfully achieved, using interpersonal conflicts as a stimulus. Given that conditioned fear caused by the interpersonal conflicts is likely associated with borderline personality traits, this paradigm could contribute to further understanding of underlying mechanisms of interpersonal fear implicated in borderline personality disorder. |
| first_indexed | 2024-12-21T04:56:53Z |
| format | Article |
| id | doaj.art-cb3a87b8f612464d8a7980a8f3e391a9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T04:56:53Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cb3a87b8f612464d8a7980a8f3e391a92022-12-21T19:15:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01105e012572910.1371/journal.pone.0125729Fear conditioning induced by interpersonal conflicts in healthy individuals.Mitsuhiro TadaHiroyuki UchidaTakaki MaedaMika KonishiSatoshi UmedaYuri TerasawaShinichiro NakajimaMasaru MimuraTomoyuki MiyazakiTakuya TakahashiPsychophysiological markers have been focused to investigate the psychopathology of psychiatric disorders and personality subtypes. In order to understand neurobiological mechanisms underlying these conditions, fear-conditioning model has been widely used. However, simple aversive stimuli are too simplistic to understand mechanisms because most patients with psychiatric disorders are affected by social stressors. The objective of this study was to test the feasibility of a newly-designed conditioning experiment using a stimulus to cause interpersonal conflicts and examine associations between personality traits and response to that stimulus. Twenty-nine healthy individuals underwent the fear conditioning and extinction experiments in response to three types of stimuli: a simple aversive sound, disgusting pictures, and pictures of an actors' face with unpleasant verbal messages that were designed to cause interpersonal conflicts. Conditioned response was quantified by the skin conductance response (SCR). Correlations between the SCR changes, and personality traits measured by the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) and Revised NEO Personality Inventory were explored. The interpersonal conflict stimulus resulted in successful conditioning, which was subsequently extinguished, in a similar manner as the other two stimuli. Moreover, a greater degree of conditioned response to the interpersonal conflict stimulus correlated with a higher ZAN-BPD total score. Fear conditioning and extinction can be successfully achieved, using interpersonal conflicts as a stimulus. Given that conditioned fear caused by the interpersonal conflicts is likely associated with borderline personality traits, this paradigm could contribute to further understanding of underlying mechanisms of interpersonal fear implicated in borderline personality disorder.http://europepmc.org/articles/PMC4433209?pdf=render |
| spellingShingle | Mitsuhiro Tada Hiroyuki Uchida Takaki Maeda Mika Konishi Satoshi Umeda Yuri Terasawa Shinichiro Nakajima Masaru Mimura Tomoyuki Miyazaki Takuya Takahashi Fear conditioning induced by interpersonal conflicts in healthy individuals. PLoS ONE |
| title | Fear conditioning induced by interpersonal conflicts in healthy individuals. |
| title_full | Fear conditioning induced by interpersonal conflicts in healthy individuals. |
| title_fullStr | Fear conditioning induced by interpersonal conflicts in healthy individuals. |
| title_full_unstemmed | Fear conditioning induced by interpersonal conflicts in healthy individuals. |
| title_short | Fear conditioning induced by interpersonal conflicts in healthy individuals. |
| title_sort | fear conditioning induced by interpersonal conflicts in healthy individuals |
| url | http://europepmc.org/articles/PMC4433209?pdf=render |
| work_keys_str_mv | AT mitsuhirotada fearconditioninginducedbyinterpersonalconflictsinhealthyindividuals AT hiroyukiuchida fearconditioninginducedbyinterpersonalconflictsinhealthyindividuals AT takakimaeda fearconditioninginducedbyinterpersonalconflictsinhealthyindividuals AT mikakonishi fearconditioninginducedbyinterpersonalconflictsinhealthyindividuals AT satoshiumeda fearconditioninginducedbyinterpersonalconflictsinhealthyindividuals AT yuriterasawa fearconditioninginducedbyinterpersonalconflictsinhealthyindividuals AT shinichironakajima fearconditioninginducedbyinterpersonalconflictsinhealthyindividuals AT masarumimura fearconditioninginducedbyinterpersonalconflictsinhealthyindividuals AT tomoyukimiyazaki fearconditioninginducedbyinterpersonalconflictsinhealthyindividuals AT takuyatakahashi fearconditioninginducedbyinterpersonalconflictsinhealthyindividuals |