The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory
Introduction: Working memory plays a critical role in cognitive processes which are central to our daily life. Neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (DLFPC). This study was aimed to assess whethe...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2013-08-01
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| Series: | Basic and Clinical Neuroscience |
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| Online Access: | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-167&slc_lang=en&sid=1 |
| _version_ | 1827331742505107456 |
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| author | Fatemeh Keshvari Hamid-Reza Pouretemad Hamed Ekhtiari |
| author_facet | Fatemeh Keshvari Hamid-Reza Pouretemad Hamed Ekhtiari |
| author_sort | Fatemeh Keshvari |
| collection | DOAJ |
| description | Introduction: Working memory plays a critical role in cognitive processes which are central to our daily life. Neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (DLFPC). This study was aimed to assess whether bilateral modulation of the DLPFC using a noninvasive brain stimulation, namely transcranial direct current stimulation (tDCS), modi.es the working memory function in healthy adults.Methods: In a randomized sham-controlled cross-over study, 60 subjects (30 Males) received sham and active tDCS in two subgroups (anode left/cathode right and anode right/cathode left) of the DLPFC. Subjects were presented working memory n-back task while the reaction time and accuracy were recorded.Results: A repeated measures, mixed design ANOVA indicated a signi.cant difference between the type of stimulation (sham vs. active) in anodal stimulation of the left DLPFC with cathodal stimulation of the right DLPFC [F(1,55)= 5.29, P=0.019], but not the inverse polarity worsened accuracy in the 2-back working memory task. There were also no statistically signi.cant changes in speed of working memory [F(1,55)= 0.458 ,P=0.502] related to type or order of stimulation..Discussion: The results would imply to a polarity dependence of bilateral tDCS of working memory. Left anodal/ right cathodal stimulation of DLPFC could impair working memory, while the reverser stimulation had no effect. Meaning that bilateral stimulation of DLFC would not be a useful procedure to improve working memory. Further studies are required to understand subtle effects of different tDCS stimulation/inhibition electrode positioning on the working memory. |
| first_indexed | 2024-03-07T16:43:42Z |
| format | Article |
| id | doaj.art-cb3ac6e0859143ea9b485dee9b1c111c |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:43:42Z |
| publishDate | 2013-08-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-cb3ac6e0859143ea9b485dee9b1c111c2024-03-03T07:15:33ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422013-08-0143224231The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working MemoryFatemeh Keshvari0Hamid-Reza Pouretemad1Hamed Ekhtiari2 Introduction: Working memory plays a critical role in cognitive processes which are central to our daily life. Neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (DLFPC). This study was aimed to assess whether bilateral modulation of the DLPFC using a noninvasive brain stimulation, namely transcranial direct current stimulation (tDCS), modi.es the working memory function in healthy adults.Methods: In a randomized sham-controlled cross-over study, 60 subjects (30 Males) received sham and active tDCS in two subgroups (anode left/cathode right and anode right/cathode left) of the DLPFC. Subjects were presented working memory n-back task while the reaction time and accuracy were recorded.Results: A repeated measures, mixed design ANOVA indicated a signi.cant difference between the type of stimulation (sham vs. active) in anodal stimulation of the left DLPFC with cathodal stimulation of the right DLPFC [F(1,55)= 5.29, P=0.019], but not the inverse polarity worsened accuracy in the 2-back working memory task. There were also no statistically signi.cant changes in speed of working memory [F(1,55)= 0.458 ,P=0.502] related to type or order of stimulation..Discussion: The results would imply to a polarity dependence of bilateral tDCS of working memory. Left anodal/ right cathodal stimulation of DLPFC could impair working memory, while the reverser stimulation had no effect. Meaning that bilateral stimulation of DLFC would not be a useful procedure to improve working memory. Further studies are required to understand subtle effects of different tDCS stimulation/inhibition electrode positioning on the working memory.http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-167&slc_lang=en&sid=1Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation Working Memory. |
| spellingShingle | Fatemeh Keshvari Hamid-Reza Pouretemad Hamed Ekhtiari The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory Basic and Clinical Neuroscience Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation Working Memory. |
| title | The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory |
| title_full | The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory |
| title_fullStr | The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory |
| title_full_unstemmed | The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory |
| title_short | The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory |
| title_sort | polarity dependent effects of the bilateral brain stimulation on working memory |
| topic | Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation Working Memory. |
| url | http://bcn.iums.ac.ir/browse.php?a_code=A-10-1-167&slc_lang=en&sid=1 |
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