β-Glucans from <i>Trametes versicolor</i> (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection
<i>Coriolus versicolor</i> (<i>C. versicolor</i>) is a higher fungi or mushroom which is now known by its accepted scientific names as <i>Trametes versicolor</i> (L.) Lloyd. Many studies have shown that β-glucans from <i>C. versicolor</i> have various...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/2/237 |
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| author | Shaohua Shi Lei Yin Xuehuai Shen Yin Dai Jieru Wang Dongdong Yin Danjun Zhang Xiaocheng Pan |
| author_facet | Shaohua Shi Lei Yin Xuehuai Shen Yin Dai Jieru Wang Dongdong Yin Danjun Zhang Xiaocheng Pan |
| author_sort | Shaohua Shi |
| collection | DOAJ |
| description | <i>Coriolus versicolor</i> (<i>C. versicolor</i>) is a higher fungi or mushroom which is now known by its accepted scientific names as <i>Trametes versicolor</i> (L.) Lloyd. Many studies have shown that β-glucans from <i>C. versicolor</i> have various physiological activities, including activating macrophages to protect against <i>Salmonella</i> infection. However, whether β-glucans have antiviral effects has not been reported. Hence, the objective of this study was to confirm whether β-glucans could boost the immune response to combat influenza virus in mouse and chick models. The results show that β-glucans induced the expression of <i>Dectin-1</i>, costimulatory molecules (<i>CD80</i>/<i>86</i>) and cytokines <i>IL-6</i>, <i>IL-1β</i>, <i>IFN-β</i> and <i>IL-10</i> in murine bone marrow dendritic cells (BMDCs). In addition, orally administered β-glucans reduced weight loss, mortality and viral titers in the lungs of mice infected with influenza virus and attenuated pathological lung damage caused by the virus in the mice. Orally administered β-glucans improved survival and reduced lung viral titers in chickens infected with H9N2 avian influenza virus. These results suggest that β-glucans have a significant antiviral effect. Therefore, β-glucans could become a potential immunomodulator against influenza virus. |
| first_indexed | 2024-03-09T20:52:57Z |
| format | Article |
| id | doaj.art-cb3beb18d4a84aa7829ded38cda5fe88 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T20:52:57Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-cb3beb18d4a84aa7829ded38cda5fe882023-11-23T22:29:41ZengMDPI AGViruses1999-49152022-01-0114223710.3390/v14020237β-Glucans from <i>Trametes versicolor</i> (L.) Lloyd Is Effective for Prevention of Influenza Virus InfectionShaohua Shi0Lei Yin1Xuehuai Shen2Yin Dai3Jieru Wang4Dongdong Yin5Danjun Zhang6Xiaocheng Pan7Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaAnhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaAnhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaAnhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaAnhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaAnhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaAnhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, ChinaAnhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Livestock and Poultry Epidemic Diseases Research Center of Anhui Province, Institute of Animal Husbandry and Veterinary Science, Anhui Academy of Agricultural Sciences, Hefei 230031, China<i>Coriolus versicolor</i> (<i>C. versicolor</i>) is a higher fungi or mushroom which is now known by its accepted scientific names as <i>Trametes versicolor</i> (L.) Lloyd. Many studies have shown that β-glucans from <i>C. versicolor</i> have various physiological activities, including activating macrophages to protect against <i>Salmonella</i> infection. However, whether β-glucans have antiviral effects has not been reported. Hence, the objective of this study was to confirm whether β-glucans could boost the immune response to combat influenza virus in mouse and chick models. The results show that β-glucans induced the expression of <i>Dectin-1</i>, costimulatory molecules (<i>CD80</i>/<i>86</i>) and cytokines <i>IL-6</i>, <i>IL-1β</i>, <i>IFN-β</i> and <i>IL-10</i> in murine bone marrow dendritic cells (BMDCs). In addition, orally administered β-glucans reduced weight loss, mortality and viral titers in the lungs of mice infected with influenza virus and attenuated pathological lung damage caused by the virus in the mice. Orally administered β-glucans improved survival and reduced lung viral titers in chickens infected with H9N2 avian influenza virus. These results suggest that β-glucans have a significant antiviral effect. Therefore, β-glucans could become a potential immunomodulator against influenza virus.https://www.mdpi.com/1999-4915/14/2/237<i>Coriolus versicolor</i>β-glucansinfluenza virusprevention |
| spellingShingle | Shaohua Shi Lei Yin Xuehuai Shen Yin Dai Jieru Wang Dongdong Yin Danjun Zhang Xiaocheng Pan β-Glucans from <i>Trametes versicolor</i> (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection Viruses <i>Coriolus versicolor</i> β-glucans influenza virus prevention |
| title | β-Glucans from <i>Trametes versicolor</i> (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection |
| title_full | β-Glucans from <i>Trametes versicolor</i> (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection |
| title_fullStr | β-Glucans from <i>Trametes versicolor</i> (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection |
| title_full_unstemmed | β-Glucans from <i>Trametes versicolor</i> (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection |
| title_short | β-Glucans from <i>Trametes versicolor</i> (L.) Lloyd Is Effective for Prevention of Influenza Virus Infection |
| title_sort | β glucans from i trametes versicolor i l lloyd is effective for prevention of influenza virus infection |
| topic | <i>Coriolus versicolor</i> β-glucans influenza virus prevention |
| url | https://www.mdpi.com/1999-4915/14/2/237 |
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