The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452R
Emerging SARS-CoV-2 variants may threaten global vaccination efforts and the awaited reduction in outbreak burden. In this study, we report a novel variant carrying the L452R mutation that emerged from a local B.1.362 lineage, B.1.362+L452R. The L452R mutation is associated with the Delta and Epsilo...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/8/937 |
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| author | Orna Mor Michal Mandelboim Shay Fleishon Efrat Bucris Dana Bar-Ilan Michal Linial Ital Nemet Limor Kliker Yaniv Lustig Israel National Consortium for SARS-CoV-2 Sequencing Ella S. Mendelson Neta S. Zuckerman |
| author_facet | Orna Mor Michal Mandelboim Shay Fleishon Efrat Bucris Dana Bar-Ilan Michal Linial Ital Nemet Limor Kliker Yaniv Lustig Israel National Consortium for SARS-CoV-2 Sequencing Ella S. Mendelson Neta S. Zuckerman |
| author_sort | Orna Mor |
| collection | DOAJ |
| description | Emerging SARS-CoV-2 variants may threaten global vaccination efforts and the awaited reduction in outbreak burden. In this study, we report a novel variant carrying the L452R mutation that emerged from a local B.1.362 lineage, B.1.362+L452R. The L452R mutation is associated with the Delta and Epsilon variants and was shown to cause increased infection and reduction in neutralization in pseudoviruses. Indeed, the B.1.362+L452R variant demonstrated a X4-fold reduction in neutralization capacity of sera from BNT162b2-vaccinated individuals compared to a wild-type strain. The variant infected 270 individuals in Israel between December 2020 and March 2021, until diminishing due to the gain in dominance of the Alpha variant in February 2021. This study demonstrates an independent, local emergence of a variant carrying a critical mutation, L452R, which may have the potential of becoming a variant of concern and emphasizes the importance of routine surveillance and detection of novel variants among efforts undertaken to prevent further disease spread. |
| first_indexed | 2024-03-10T08:18:57Z |
| format | Article |
| id | doaj.art-cb3ca8e521774439a132eaf631cfd0da |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T08:18:57Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-cb3ca8e521774439a132eaf631cfd0da2023-11-22T10:08:19ZengMDPI AGVaccines2076-393X2021-08-019893710.3390/vaccines9080937The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452ROrna Mor0Michal Mandelboim1Shay Fleishon2Efrat Bucris3Dana Bar-Ilan4Michal Linial5Ital Nemet6Limor Kliker7Yaniv Lustig8Israel National Consortium for SARS-CoV-2 SequencingElla S. Mendelson9Neta S. Zuckerman10Central Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center, Tel-Hashomer 52621, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center, Tel-Hashomer 52621, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center, Tel-Hashomer 52621, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center, Tel-Hashomer 52621, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center, Tel-Hashomer 52621, IsraelDepartment of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center, Tel-Hashomer 52621, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center, Tel-Hashomer 52621, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center, Tel-Hashomer 52621, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center, Tel-Hashomer 52621, IsraelCentral Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center, Tel-Hashomer 52621, IsraelEmerging SARS-CoV-2 variants may threaten global vaccination efforts and the awaited reduction in outbreak burden. In this study, we report a novel variant carrying the L452R mutation that emerged from a local B.1.362 lineage, B.1.362+L452R. The L452R mutation is associated with the Delta and Epsilon variants and was shown to cause increased infection and reduction in neutralization in pseudoviruses. Indeed, the B.1.362+L452R variant demonstrated a X4-fold reduction in neutralization capacity of sera from BNT162b2-vaccinated individuals compared to a wild-type strain. The variant infected 270 individuals in Israel between December 2020 and March 2021, until diminishing due to the gain in dominance of the Alpha variant in February 2021. This study demonstrates an independent, local emergence of a variant carrying a critical mutation, L452R, which may have the potential of becoming a variant of concern and emphasizes the importance of routine surveillance and detection of novel variants among efforts undertaken to prevent further disease spread.https://www.mdpi.com/2076-393X/9/8/937SARS-CoV-2variantmutationsequencingneutralization |
| spellingShingle | Orna Mor Michal Mandelboim Shay Fleishon Efrat Bucris Dana Bar-Ilan Michal Linial Ital Nemet Limor Kliker Yaniv Lustig Israel National Consortium for SARS-CoV-2 Sequencing Ella S. Mendelson Neta S. Zuckerman The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452R Vaccines SARS-CoV-2 variant mutation sequencing neutralization |
| title | The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452R |
| title_full | The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452R |
| title_fullStr | The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452R |
| title_full_unstemmed | The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452R |
| title_short | The Rise and Fall of a Local SARS-CoV-2 Variant with the Spike Protein Mutation L452R |
| title_sort | rise and fall of a local sars cov 2 variant with the spike protein mutation l452r |
| topic | SARS-CoV-2 variant mutation sequencing neutralization |
| url | https://www.mdpi.com/2076-393X/9/8/937 |
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