Advances of gold nanoclusters for bioimaging

Summary: Gold nanoclusters (AuNCs) have become a promising material for bioimaging detection because of their tunable photoluminescence, large Stokes shift, low photobleaching, and good biocompatibility. Last decade, great efforts have been made to develop AuNCs for enhanced imaging contrast and mul...

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Main Authors: Cheng Zhang, Xiaobing Gao, Wenrui Chen, Meng He, Yao Yu, Guanbin Gao, Taolei Sun
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222012949
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author Cheng Zhang
Xiaobing Gao
Wenrui Chen
Meng He
Yao Yu
Guanbin Gao
Taolei Sun
author_facet Cheng Zhang
Xiaobing Gao
Wenrui Chen
Meng He
Yao Yu
Guanbin Gao
Taolei Sun
author_sort Cheng Zhang
collection DOAJ
description Summary: Gold nanoclusters (AuNCs) have become a promising material for bioimaging detection because of their tunable photoluminescence, large Stokes shift, low photobleaching, and good biocompatibility. Last decade, great efforts have been made to develop AuNCs for enhanced imaging contrast and multimodal imaging. Herein, an updated overview of recent advances in AuNCs was present for visible fluorescence (FL) imaging, near-infrared fluorescence (NIR-FL) imaging, two-photon near-infrared fluorescence (TP-NIR-FL) imaging, computed tomography (CT) imaging, positron emission tomography (PET) imaging, magnetic resonance imaging (MRI), and photoacoustic (PA) imaging. The justification of AuNCs applied in bioimaging mentioned above applications was discussed, the performance location of different AuNCs were summarized and highlighted in an unified parameter coordinate system of corresponding bioimaging, and the current challenges, research frontiers, and prospects of AuNCs in bioimaging were discussed. This review will bring new insights into the future development of AuNCs in bio-diagnostic imaging.
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spelling doaj.art-cb3cd8ce49bd4b0aa4dbe836aaa0a28f2022-12-22T01:52:21ZengElsevieriScience2589-00422022-10-012510105022Advances of gold nanoclusters for bioimagingCheng Zhang0Xiaobing Gao1Wenrui Chen2Meng He3Yao Yu4Guanbin Gao5Taolei Sun6State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, ChinaGeneral Hospital of Central Theater Command, Wuhan 430070, ChinaState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, ChinaSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, ChinaSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, ChinaState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China; Corresponding authorState Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China; Corresponding authorSummary: Gold nanoclusters (AuNCs) have become a promising material for bioimaging detection because of their tunable photoluminescence, large Stokes shift, low photobleaching, and good biocompatibility. Last decade, great efforts have been made to develop AuNCs for enhanced imaging contrast and multimodal imaging. Herein, an updated overview of recent advances in AuNCs was present for visible fluorescence (FL) imaging, near-infrared fluorescence (NIR-FL) imaging, two-photon near-infrared fluorescence (TP-NIR-FL) imaging, computed tomography (CT) imaging, positron emission tomography (PET) imaging, magnetic resonance imaging (MRI), and photoacoustic (PA) imaging. The justification of AuNCs applied in bioimaging mentioned above applications was discussed, the performance location of different AuNCs were summarized and highlighted in an unified parameter coordinate system of corresponding bioimaging, and the current challenges, research frontiers, and prospects of AuNCs in bioimaging were discussed. This review will bring new insights into the future development of AuNCs in bio-diagnostic imaging.http://www.sciencedirect.com/science/article/pii/S2589004222012949Medical imagingOptical imagingNanomaterials
spellingShingle Cheng Zhang
Xiaobing Gao
Wenrui Chen
Meng He
Yao Yu
Guanbin Gao
Taolei Sun
Advances of gold nanoclusters for bioimaging
iScience
Medical imaging
Optical imaging
Nanomaterials
title Advances of gold nanoclusters for bioimaging
title_full Advances of gold nanoclusters for bioimaging
title_fullStr Advances of gold nanoclusters for bioimaging
title_full_unstemmed Advances of gold nanoclusters for bioimaging
title_short Advances of gold nanoclusters for bioimaging
title_sort advances of gold nanoclusters for bioimaging
topic Medical imaging
Optical imaging
Nanomaterials
url http://www.sciencedirect.com/science/article/pii/S2589004222012949
work_keys_str_mv AT chengzhang advancesofgoldnanoclustersforbioimaging
AT xiaobinggao advancesofgoldnanoclustersforbioimaging
AT wenruichen advancesofgoldnanoclustersforbioimaging
AT menghe advancesofgoldnanoclustersforbioimaging
AT yaoyu advancesofgoldnanoclustersforbioimaging
AT guanbingao advancesofgoldnanoclustersforbioimaging
AT taoleisun advancesofgoldnanoclustersforbioimaging