Serum Biomarker Concentrations upon Admission in Acute Traumatic Brain Injury: Associations with TBI Severity, <i>Toxoplasma gondii</i> Infection, and Outcome in a Referral Hospital Setting in Cameroon
Despite the available literature on traumatic brain injury (TBI) biomarkers elsewhere, data are limited or non-existent in sub-Saharan Africa (SSA). The aim of the study was to analyse associations in acute TBI between the admission serum biomarker concentrations and TBI severity, CT-scan findings,...
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MDPI AG
2023-07-01
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| Series: | NeuroSci |
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| Online Access: | https://www.mdpi.com/2673-4087/4/3/15 |
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| author | Franklin Chu Buh Germain Sotoing Taiwe Firas H. Kobeissy Kevin W. Wang Andrew I. R. Maas Mathieu Motah Basil Kum Meh Eric Youm Peter J. A. Hutchinson Irene Ule Ngole Sumbele |
| author_facet | Franklin Chu Buh Germain Sotoing Taiwe Firas H. Kobeissy Kevin W. Wang Andrew I. R. Maas Mathieu Motah Basil Kum Meh Eric Youm Peter J. A. Hutchinson Irene Ule Ngole Sumbele |
| author_sort | Franklin Chu Buh |
| collection | DOAJ |
| description | Despite the available literature on traumatic brain injury (TBI) biomarkers elsewhere, data are limited or non-existent in sub-Saharan Africa (SSA). The aim of the study was to analyse associations in acute TBI between the admission serum biomarker concentrations and TBI severity, CT-scan findings, and outcome, as well as to explore the influence of concurrent <i>Toxoplasma gondii</i> infection. The concentrations of serum biomarkers (GFAP, NFL Tau, UCH-L1, and S100B) were measured and <i>Toxoplasma gondii</i> were detected in the samples obtained <24 h post injury. GOSE was used to evaluate the 6-month outcome. All of the biomarker levels increased with the severity of TBI, but this increase was significant only for NFL (<i>p</i> = 0.01). The GFAP values significantly increased (<i>p</i> = 0.026) in those with an unfavourable outcome. The Tau levels were higher in those who died (<i>p</i> = 0.017). GFAP and NFL were sensitive to CT-scan pathology (<i>p</i> values of 0.004 and 0.002, respectively). The S100B levels were higher (<i>p</i> < 0.001) in TBI patients seropositive to <i>Toxoplasma gondii.</i> In conclusion, NFL was found to be sensitive to TBI severity, while NFL and GFAP were predictive of CT intracranial abnormalities. Increased levels of GFAP and Tau were associated with poorer outcomes 6 months after TBI, and the S100B levels were significantly affected by concurrent <i>T. gondii</i> infection in TBI patients compared with the seronegative patients. |
| first_indexed | 2024-03-10T22:21:39Z |
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| institution | Directory Open Access Journal |
| issn | 2673-4087 |
| language | English |
| last_indexed | 2024-03-10T22:21:39Z |
| publishDate | 2023-07-01 |
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| series | NeuroSci |
| spelling | doaj.art-cb3d06e3813a4f33874671744252c55e2023-11-19T12:16:04ZengMDPI AGNeuroSci2673-40872023-07-014316417710.3390/neurosci4030015Serum Biomarker Concentrations upon Admission in Acute Traumatic Brain Injury: Associations with TBI Severity, <i>Toxoplasma gondii</i> Infection, and Outcome in a Referral Hospital Setting in CameroonFranklin Chu Buh0Germain Sotoing Taiwe1Firas H. Kobeissy2Kevin W. Wang3Andrew I. R. Maas4Mathieu Motah5Basil Kum Meh6Eric Youm7Peter J. A. Hutchinson8Irene Ule Ngole Sumbele9Department of Animal Biology and Conservation, Faculty of Science, University of Buea, Buea P.O. Box 63, CameroonDepartment of Animal Biology and Conservation, Faculty of Science, University of Buea, Buea P.O. Box 63, CameroonCenter for Neurotrauma, Multiomics & Biomarkers (CNMB), Department of Neurobiology, Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310-1458, USACenter for Neurotrauma, Multiomics & Biomarkers (CNMB), Department of Neurobiology, Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310-1458, USADepartment of Neurosurgery, Antwerp University Hospital, University of Antwerp, 2000 Edegem, BelgiumDepartment of Surgery, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala P.O. Box 2701, CameroonDepartment of Animal Biology and Conservation, Faculty of Science, University of Buea, Buea P.O. Box 63, CameroonHolo Healthcare, Nairobi 00400, KenyaDepartment of Clinical Neuroscience, University of Cambridge, Cambridge CB2 0QQ, UKDepartment of Animal Biology and Conservation, Faculty of Science, University of Buea, Buea P.O. Box 63, CameroonDespite the available literature on traumatic brain injury (TBI) biomarkers elsewhere, data are limited or non-existent in sub-Saharan Africa (SSA). The aim of the study was to analyse associations in acute TBI between the admission serum biomarker concentrations and TBI severity, CT-scan findings, and outcome, as well as to explore the influence of concurrent <i>Toxoplasma gondii</i> infection. The concentrations of serum biomarkers (GFAP, NFL Tau, UCH-L1, and S100B) were measured and <i>Toxoplasma gondii</i> were detected in the samples obtained <24 h post injury. GOSE was used to evaluate the 6-month outcome. All of the biomarker levels increased with the severity of TBI, but this increase was significant only for NFL (<i>p</i> = 0.01). The GFAP values significantly increased (<i>p</i> = 0.026) in those with an unfavourable outcome. The Tau levels were higher in those who died (<i>p</i> = 0.017). GFAP and NFL were sensitive to CT-scan pathology (<i>p</i> values of 0.004 and 0.002, respectively). The S100B levels were higher (<i>p</i> < 0.001) in TBI patients seropositive to <i>Toxoplasma gondii.</i> In conclusion, NFL was found to be sensitive to TBI severity, while NFL and GFAP were predictive of CT intracranial abnormalities. Increased levels of GFAP and Tau were associated with poorer outcomes 6 months after TBI, and the S100B levels were significantly affected by concurrent <i>T. gondii</i> infection in TBI patients compared with the seronegative patients.https://www.mdpi.com/2673-4087/4/3/15serum biomarkerstraumatic brain injuryCT-scan findingsoutcome<i>Toxoplasma gondii</i> |
| spellingShingle | Franklin Chu Buh Germain Sotoing Taiwe Firas H. Kobeissy Kevin W. Wang Andrew I. R. Maas Mathieu Motah Basil Kum Meh Eric Youm Peter J. A. Hutchinson Irene Ule Ngole Sumbele Serum Biomarker Concentrations upon Admission in Acute Traumatic Brain Injury: Associations with TBI Severity, <i>Toxoplasma gondii</i> Infection, and Outcome in a Referral Hospital Setting in Cameroon NeuroSci serum biomarkers traumatic brain injury CT-scan findings outcome <i>Toxoplasma gondii</i> |
| title | Serum Biomarker Concentrations upon Admission in Acute Traumatic Brain Injury: Associations with TBI Severity, <i>Toxoplasma gondii</i> Infection, and Outcome in a Referral Hospital Setting in Cameroon |
| title_full | Serum Biomarker Concentrations upon Admission in Acute Traumatic Brain Injury: Associations with TBI Severity, <i>Toxoplasma gondii</i> Infection, and Outcome in a Referral Hospital Setting in Cameroon |
| title_fullStr | Serum Biomarker Concentrations upon Admission in Acute Traumatic Brain Injury: Associations with TBI Severity, <i>Toxoplasma gondii</i> Infection, and Outcome in a Referral Hospital Setting in Cameroon |
| title_full_unstemmed | Serum Biomarker Concentrations upon Admission in Acute Traumatic Brain Injury: Associations with TBI Severity, <i>Toxoplasma gondii</i> Infection, and Outcome in a Referral Hospital Setting in Cameroon |
| title_short | Serum Biomarker Concentrations upon Admission in Acute Traumatic Brain Injury: Associations with TBI Severity, <i>Toxoplasma gondii</i> Infection, and Outcome in a Referral Hospital Setting in Cameroon |
| title_sort | serum biomarker concentrations upon admission in acute traumatic brain injury associations with tbi severity i toxoplasma gondii i infection and outcome in a referral hospital setting in cameroon |
| topic | serum biomarkers traumatic brain injury CT-scan findings outcome <i>Toxoplasma gondii</i> |
| url | https://www.mdpi.com/2673-4087/4/3/15 |
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