TNF-α/TNFR1 regulates the polarization of Kupffer cells to mediate trichloroethylene-induced liver injury

TNF-α/TNFR1 regulates the polarization of Kupffer cells to mediate trichloroethylene-induced liver injury

We have previously shown trichloroethylene (TCE) induced immune liver injury, and TNF-α/TNFR1 pathway as a probably mechanism underlying the immune damage, but the pathogenic mechanism is still unclear. The study aims to investigate whether TNF-α and its receptors regulate Kupffer cell polarization...

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Bibliographic Details
Main Authors: Jia-xiang Zhang, Yi Yang, Hua Huang, Hai-bo Xie, Meng Huang, Wei Jiang, Bai-wang Ding, Qi-xing Zhu
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Trichloroethylene
Liver injury
TNF-α
Kupffer cell
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321012537

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