Effect of Topical Clove (Syzygium aromaticum (L.) Merr. & L.M.Perry) Gel on Premature Ejaculation: A Pilot Randomized Double-Blind Placebo-Controlled Clinical Trial
Premature ejaculation is one of the most common sexual disorders worldwide without a satisfying treatment. In this study, we investigated the efficacy of a topical formulation of clove oil in premature ejaculation patients. Eligible patients were randomly divided into two groups to use either Syzygi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2021-09-01
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| Series: | Traditional and Integrative Medicine |
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| Online Access: | https://jtim.tums.ac.ir/index.php/jtim/article/view/382 |
| _version_ | 1798029266780160000 |
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| author | Ahmad Reza Sharifi Olounabadi Fereidoun Khayyamfar Mohammad Kamalinejad Mahmood Salesi Fatemeh Alijaniha Fatemeh Emadi Farzaneh Ghaffari Babak Daneshfard Mohsen Naseri |
| author_facet | Ahmad Reza Sharifi Olounabadi Fereidoun Khayyamfar Mohammad Kamalinejad Mahmood Salesi Fatemeh Alijaniha Fatemeh Emadi Farzaneh Ghaffari Babak Daneshfard Mohsen Naseri |
| author_sort | Ahmad Reza Sharifi Olounabadi |
| collection | DOAJ |
| description | Premature ejaculation is one of the most common sexual disorders worldwide without a satisfying treatment. In this study, we investigated the efficacy of a topical formulation of clove oil in premature ejaculation patients. Eligible patients were randomly divided into two groups to use either Syzygium aromaticum (SA) 1% gel or placebo gel 10 minutes before the intercourse for a period of 8 weeks. Outcome measurement were Premature Ejaculation Diagnostic Tool (PEDT) and International Index of Erectile Function (IIEF) questionnaires in addition to Intravaginal Ejaculation Latency Time (IELT). A total number of 22 (11 patients in each group) participants completed the study. At the end of the intervention, the IELT scores changed from 29.84 ± 18.59 to 97.09 ± 91.86 and 42.51 ± 13.98 to 52.45 ± 32.7 seconds in SA gel and placebo groups, respectively (p-value = 0.003). Also, the changes of PEDT scores in the SA gel group (from 14 ± 3.55 to 9.2 ± 4.56) comparing to that of placebo gel group (from 14.63 ± 3.61 to 13.5 ± 3.78) was significantly different (p-value =0.001). Moreover, results of IIEF questionnaire revealed significant improvement of “Intercourse Satisfaction” in SA gel group (p-value = 0.016). No adverse event was observed. It seems that SA gel could be beneficial in the treatment of premature ejaculation; however, it should be further evaluated in larger studies. |
| first_indexed | 2024-04-11T19:21:22Z |
| format | Article |
| id | doaj.art-cb3f166b8c5f4c799ee58f434d786ab4 |
| institution | Directory Open Access Journal |
| issn | 2476-5104 2476-5112 |
| language | English |
| last_indexed | 2024-04-11T19:21:22Z |
| publishDate | 2021-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Traditional and Integrative Medicine |
| spelling | doaj.art-cb3f166b8c5f4c799ee58f434d786ab42022-12-22T04:07:17ZengTehran University of Medical SciencesTraditional and Integrative Medicine2476-51042476-51122021-09-016310.18502/tim.v6i3.7312Effect of Topical Clove (Syzygium aromaticum (L.) Merr. & L.M.Perry) Gel on Premature Ejaculation: A Pilot Randomized Double-Blind Placebo-Controlled Clinical TrialAhmad Reza Sharifi Olounabadi0Fereidoun Khayyamfar1Mohammad Kamalinejad2Mahmood Salesi3Fatemeh Alijaniha4Fatemeh Emadi5Farzaneh Ghaffari6Babak Daneshfard7Mohsen Naseri8Medicine, Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran AND Department of Traditional Persian Medicine, School of Medicine, Shahed University, Tehran, IranDepartment of Urology, Faculty of Medicine, Shahed University, Tehran, IranSchool of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IranChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, IranTraditional Medicine Clinical Trial Research Center, Shahed University, Tehran, IranDepartment of Traditional Persian Medicine, School of Medicine, Shahed University, Tehran, Iran AND Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, IranSchool of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranIntegrative Medicine Research Unit, Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Traditional Persian Medicine, School of Medicine, Shahed University, Tehran, Iran AND Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran AND Hikmat, Islamic and Traditional Medicine Department, The Academy of Medical Sciences, Tehran, IranPremature ejaculation is one of the most common sexual disorders worldwide without a satisfying treatment. In this study, we investigated the efficacy of a topical formulation of clove oil in premature ejaculation patients. Eligible patients were randomly divided into two groups to use either Syzygium aromaticum (SA) 1% gel or placebo gel 10 minutes before the intercourse for a period of 8 weeks. Outcome measurement were Premature Ejaculation Diagnostic Tool (PEDT) and International Index of Erectile Function (IIEF) questionnaires in addition to Intravaginal Ejaculation Latency Time (IELT). A total number of 22 (11 patients in each group) participants completed the study. At the end of the intervention, the IELT scores changed from 29.84 ± 18.59 to 97.09 ± 91.86 and 42.51 ± 13.98 to 52.45 ± 32.7 seconds in SA gel and placebo groups, respectively (p-value = 0.003). Also, the changes of PEDT scores in the SA gel group (from 14 ± 3.55 to 9.2 ± 4.56) comparing to that of placebo gel group (from 14.63 ± 3.61 to 13.5 ± 3.78) was significantly different (p-value =0.001). Moreover, results of IIEF questionnaire revealed significant improvement of “Intercourse Satisfaction” in SA gel group (p-value = 0.016). No adverse event was observed. It seems that SA gel could be beneficial in the treatment of premature ejaculation; however, it should be further evaluated in larger studies.https://jtim.tums.ac.ir/index.php/jtim/article/view/382CloveEugenia caryophyllata ThunbIntegrative medicinePremature ejaculationPersian medicineRandomized controlled trial |
| spellingShingle | Ahmad Reza Sharifi Olounabadi Fereidoun Khayyamfar Mohammad Kamalinejad Mahmood Salesi Fatemeh Alijaniha Fatemeh Emadi Farzaneh Ghaffari Babak Daneshfard Mohsen Naseri Effect of Topical Clove (Syzygium aromaticum (L.) Merr. & L.M.Perry) Gel on Premature Ejaculation: A Pilot Randomized Double-Blind Placebo-Controlled Clinical Trial Traditional and Integrative Medicine Clove Eugenia caryophyllata Thunb Integrative medicine Premature ejaculation Persian medicine Randomized controlled trial |
| title | Effect of Topical Clove (Syzygium aromaticum (L.) Merr. & L.M.Perry) Gel on Premature Ejaculation: A Pilot Randomized Double-Blind Placebo-Controlled Clinical Trial |
| title_full | Effect of Topical Clove (Syzygium aromaticum (L.) Merr. & L.M.Perry) Gel on Premature Ejaculation: A Pilot Randomized Double-Blind Placebo-Controlled Clinical Trial |
| title_fullStr | Effect of Topical Clove (Syzygium aromaticum (L.) Merr. & L.M.Perry) Gel on Premature Ejaculation: A Pilot Randomized Double-Blind Placebo-Controlled Clinical Trial |
| title_full_unstemmed | Effect of Topical Clove (Syzygium aromaticum (L.) Merr. & L.M.Perry) Gel on Premature Ejaculation: A Pilot Randomized Double-Blind Placebo-Controlled Clinical Trial |
| title_short | Effect of Topical Clove (Syzygium aromaticum (L.) Merr. & L.M.Perry) Gel on Premature Ejaculation: A Pilot Randomized Double-Blind Placebo-Controlled Clinical Trial |
| title_sort | effect of topical clove syzygium aromaticum l merr l m perry gel on premature ejaculation a pilot randomized double blind placebo controlled clinical trial |
| topic | Clove Eugenia caryophyllata Thunb Integrative medicine Premature ejaculation Persian medicine Randomized controlled trial |
| url | https://jtim.tums.ac.ir/index.php/jtim/article/view/382 |
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