Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance

Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance

Ovarian Cancer (OVCA) is the most fatal gynecologic cancer and has a 5-year survival rate less than 45%. This is mainly due to late diagnosis and drug resistance. Overexpression of plasma gelsolin (pGSN) is key contributing factor to OVCA chemoresistance and immunosuppression. Gelsolin (GSN) is a mu...

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Bibliographic Details
Main Authors: Toshimichi Onuma, Meshach Asare-Werehene, Yoshio Yoshida, Benjamin K. Tsang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
plasma gelsolin (pGSN)
extracellular vesicles (EVs)
chemoresistance
tumor microenvironment (TME)
ovarian cancer
immune cells
Online Access:https://www.mdpi.com/2073-4409/11/20/3305

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