Association of M-Type Phospholipase A2 Receptor Deposition in Kidney Tissue with Treatment Outcomes in Patients with Idiopathic Membranous Nephropathy
Ning-Qiu Xie,1,* Yu-Lin Zhang,2,* Zi-Li Zheng,1 Quan-Lin Zheng,1 Ruo-Ji Chen1 1Department of Nephrology, Jinjiang Municipal Hospital, Jinjiang, Fujian, 362200, People’s Republic of China; 2Department of Pediatric, Jinjiang Municipal Hospital, Jinjiang, Fujian, 362200, People’s Republ...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-12-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/association-of-m-type-phospholipase-a2-receptor-deposition-in-kidney-t-peer-reviewed-fulltext-article-JIR |
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| author | Xie NQ Zhang YL Zheng ZL Zheng QL Chen RJ |
| author_facet | Xie NQ Zhang YL Zheng ZL Zheng QL Chen RJ |
| author_sort | Xie NQ |
| collection | DOAJ |
| description | Ning-Qiu Xie,1,* Yu-Lin Zhang,2,* Zi-Li Zheng,1 Quan-Lin Zheng,1 Ruo-Ji Chen1 1Department of Nephrology, Jinjiang Municipal Hospital, Jinjiang, Fujian, 362200, People’s Republic of China; 2Department of Pediatric, Jinjiang Municipal Hospital, Jinjiang, Fujian, 362200, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ruo-Ji Chen, Department of Nephrology, Jinjiang Municipal Hospital, Baolong International Community, Changxing Road, 288 Qingyang Street, Jinjiang, Fujian, 362200, People’s Republic of China, Tel +86 13665970368, Email ruojichencrj@126.comObjective: The purpose of this study was to investigate the correlation between the deposition of M-type phospholipase A2 receptor (PLA2R) in the kidney tissues of patients with idiopathic membranous nephropathy (IMN).Method: We enrolled a total of 61 patients diagnosed with IMN in the past 8 years who were admitted at the Jinjiang Municipal Hospital and the 2nd Affiliated Hospital of Fujian Medical University. PLA2R immunofluorescence was used to stain kidney tissues, and all patients were treated with steroid combined with immunosuppressive agents or conservative regimens. The duration of follow-up was more than 48 weeks. Based on the deposition of PLA2R in kidney tissues, we divided the patients into the PLA2R Positive group and the PLA2R Negative group. Further, patients with PLA2R-positive kidney tissues were divided into “ 1+”, “ 2+”, and “ 3+” groups based on the extent of their PLA2R deposition, and we compared the therapeutic outcomes of the various groups.Results: At week 12 of follow-up, the partial remission rate of kidney tissues in the PLA2R Negative group was significantly higher than that in the Positive group (P = 0.004). Among the various deposition groups with PLA2R-positive kidney tissues, the complete remission rate of the “ 2+” group was higher than that of the “ 3+” group at weeks 24, 36, and 48 of follow-up (P < 0.05). In IMN patients treated with a combination regimen of steroid and tacrolimus, the complete remission rate in kidney tissues of the PLA2R Negative group was higher than that of the Positive group at weeks 24 and 48 of follow-up (P < 0.05).Conclusion: The overall effective rate of treatment in kidney tissues of PLA2R-negative patients was higher than that in the kidney tissues of PLA2R-positive patients. The varied levels of PLA2R deposition in kidney tissues were related to the treatment outcomes of IMN, and those with lower PLA2R deposition levels had better outcomes.Keywords: anti-M-type phospholipase A2 receptor, idiopathic membranous nephropathy, IgG4 |
| first_indexed | 2024-03-08T19:22:53Z |
| format | Article |
| id | doaj.art-cb415ea0d6d84c13abefc6dad50e600a |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-03-08T19:22:53Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-cb415ea0d6d84c13abefc6dad50e600a2023-12-26T18:05:30ZengDove Medical PressJournal of Inflammation Research1178-70312023-12-01Volume 166319632889260Association of M-Type Phospholipase A2 Receptor Deposition in Kidney Tissue with Treatment Outcomes in Patients with Idiopathic Membranous NephropathyXie NQZhang YLZheng ZLZheng QLChen RJNing-Qiu Xie,1,* Yu-Lin Zhang,2,* Zi-Li Zheng,1 Quan-Lin Zheng,1 Ruo-Ji Chen1 1Department of Nephrology, Jinjiang Municipal Hospital, Jinjiang, Fujian, 362200, People’s Republic of China; 2Department of Pediatric, Jinjiang Municipal Hospital, Jinjiang, Fujian, 362200, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ruo-Ji Chen, Department of Nephrology, Jinjiang Municipal Hospital, Baolong International Community, Changxing Road, 288 Qingyang Street, Jinjiang, Fujian, 362200, People’s Republic of China, Tel +86 13665970368, Email ruojichencrj@126.comObjective: The purpose of this study was to investigate the correlation between the deposition of M-type phospholipase A2 receptor (PLA2R) in the kidney tissues of patients with idiopathic membranous nephropathy (IMN).Method: We enrolled a total of 61 patients diagnosed with IMN in the past 8 years who were admitted at the Jinjiang Municipal Hospital and the 2nd Affiliated Hospital of Fujian Medical University. PLA2R immunofluorescence was used to stain kidney tissues, and all patients were treated with steroid combined with immunosuppressive agents or conservative regimens. The duration of follow-up was more than 48 weeks. Based on the deposition of PLA2R in kidney tissues, we divided the patients into the PLA2R Positive group and the PLA2R Negative group. Further, patients with PLA2R-positive kidney tissues were divided into “ 1+”, “ 2+”, and “ 3+” groups based on the extent of their PLA2R deposition, and we compared the therapeutic outcomes of the various groups.Results: At week 12 of follow-up, the partial remission rate of kidney tissues in the PLA2R Negative group was significantly higher than that in the Positive group (P = 0.004). Among the various deposition groups with PLA2R-positive kidney tissues, the complete remission rate of the “ 2+” group was higher than that of the “ 3+” group at weeks 24, 36, and 48 of follow-up (P < 0.05). In IMN patients treated with a combination regimen of steroid and tacrolimus, the complete remission rate in kidney tissues of the PLA2R Negative group was higher than that of the Positive group at weeks 24 and 48 of follow-up (P < 0.05).Conclusion: The overall effective rate of treatment in kidney tissues of PLA2R-negative patients was higher than that in the kidney tissues of PLA2R-positive patients. The varied levels of PLA2R deposition in kidney tissues were related to the treatment outcomes of IMN, and those with lower PLA2R deposition levels had better outcomes.Keywords: anti-M-type phospholipase A2 receptor, idiopathic membranous nephropathy, IgG4https://www.dovepress.com/association-of-m-type-phospholipase-a2-receptor-deposition-in-kidney-t-peer-reviewed-fulltext-article-JIRanti-m-type phospholipase a2 receptoridiopathic membranous nephropathyigg4 |
| spellingShingle | Xie NQ Zhang YL Zheng ZL Zheng QL Chen RJ Association of M-Type Phospholipase A2 Receptor Deposition in Kidney Tissue with Treatment Outcomes in Patients with Idiopathic Membranous Nephropathy Journal of Inflammation Research anti-m-type phospholipase a2 receptor idiopathic membranous nephropathy igg4 |
| title | Association of M-Type Phospholipase A2 Receptor Deposition in Kidney Tissue with Treatment Outcomes in Patients with Idiopathic Membranous Nephropathy |
| title_full | Association of M-Type Phospholipase A2 Receptor Deposition in Kidney Tissue with Treatment Outcomes in Patients with Idiopathic Membranous Nephropathy |
| title_fullStr | Association of M-Type Phospholipase A2 Receptor Deposition in Kidney Tissue with Treatment Outcomes in Patients with Idiopathic Membranous Nephropathy |
| title_full_unstemmed | Association of M-Type Phospholipase A2 Receptor Deposition in Kidney Tissue with Treatment Outcomes in Patients with Idiopathic Membranous Nephropathy |
| title_short | Association of M-Type Phospholipase A2 Receptor Deposition in Kidney Tissue with Treatment Outcomes in Patients with Idiopathic Membranous Nephropathy |
| title_sort | association of m type phospholipase a2 receptor deposition in kidney tissue with treatment outcomes in patients with idiopathic membranous nephropathy |
| topic | anti-m-type phospholipase a2 receptor idiopathic membranous nephropathy igg4 |
| url | https://www.dovepress.com/association-of-m-type-phospholipase-a2-receptor-deposition-in-kidney-t-peer-reviewed-fulltext-article-JIR |
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