Common occurrence of hotspots of single strand DNA breaks at transcriptional start sites

Common occurrence of hotspots of single strand DNA breaks at transcriptional start sites

Abstract Background We recently developed two high-resolution methods for genome-wide mapping of two prominent types of DNA damage, single-strand DNA breaks (SSBs) and abasic (AP) sites and found highly complex and non-random patterns of these lesions in mammalian genomes. One salient feature of SSB...

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Bibliographic Details
Main Authors: Huifen Cao, Yufei Zhang, Tianrong Song, Lu Xia, Ye Cai, Philipp Kapranov
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Genomics
Subjects:
Breakome
Single strand DNA break
Abasic site
Transcription start site
Hotspot
Online Access:https://doi.org/10.1186/s12864-024-10284-4

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