The Mechanism and Clinical Significance of Circular RNAs in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors worldwide. In view of the lack of early obvious clinical symptoms and related early diagnostic biomarkers with high specificity and sensitivity, most HCC patients are already at the advanced stages at the time of diagnosis,...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-09-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.714665/full |
| _version_ | 1818729137445011456 |
|---|---|
| author | Ziyue Huang Haoming Xia Shuqiang Liu Xudong Zhao Risheng He Zhongrui Wang Wenguang Shi Wangming Chen Pengcheng Kang Zhilei Su Yunfu Cui Judy Wai Ping Yam Yi Xu Yi Xu Yi Xu |
| author_facet | Ziyue Huang Haoming Xia Shuqiang Liu Xudong Zhao Risheng He Zhongrui Wang Wenguang Shi Wangming Chen Pengcheng Kang Zhilei Su Yunfu Cui Judy Wai Ping Yam Yi Xu Yi Xu Yi Xu |
| author_sort | Ziyue Huang |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors worldwide. In view of the lack of early obvious clinical symptoms and related early diagnostic biomarkers with high specificity and sensitivity, most HCC patients are already at the advanced stages at the time of diagnosis, and most of them are accompanied by distant metastasis. Furthermore, the unsatisfactory effect of the follow-up palliative care contributes to the poor overall survival of HCC patients. Therefore, it is urgent to identify effective early diagnosis and prognostic biomarkers and to explore novel therapeutic approaches to improve the prognosis of HCC patients. Circular RNA (CircRNA), a class of plentiful, stable, and highly conserved ncRNA subgroup with the covalent closed loop, is dysregulated in HCC. Increasingly, emerging evidence have confirmed that dysregulated circRNAs can regulate gene expression at the transcriptional or post-transcriptional level, mediating various malignant biological behaviors of HCC cells, including proliferation, invasion, metastasis, immune escape, stemness, and drug resistance, etc.; meanwhile, they are regarded as potential biomarkers for early diagnosis and prognostic evaluation of HCC. This article reviews the research progress of circRNAs in HCC, expounding the potential molecular mechanisms of dysregulated circRNAs in the carcinogenesis and development of HCC, and discusses those application prospects in the diagnosis and prognosis of HCC. |
| first_indexed | 2024-12-17T22:41:06Z |
| format | Article |
| id | doaj.art-cb42de65130c4ec5b86f8efdf18b5243 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T22:41:06Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-cb42de65130c4ec5b86f8efdf18b52432022-12-21T21:29:56ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-09-011110.3389/fonc.2021.714665714665The Mechanism and Clinical Significance of Circular RNAs in Hepatocellular CarcinomaZiyue Huang0Haoming Xia1Shuqiang Liu2Xudong Zhao3Risheng He4Zhongrui Wang5Wenguang Shi6Wangming Chen7Pengcheng Kang8Zhilei Su9Yunfu Cui10Judy Wai Ping Yam11Yi Xu12Yi Xu13Yi Xu14Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, SAR ChinaDepartment of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, SAR ChinaThe Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, ChinaHepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors worldwide. In view of the lack of early obvious clinical symptoms and related early diagnostic biomarkers with high specificity and sensitivity, most HCC patients are already at the advanced stages at the time of diagnosis, and most of them are accompanied by distant metastasis. Furthermore, the unsatisfactory effect of the follow-up palliative care contributes to the poor overall survival of HCC patients. Therefore, it is urgent to identify effective early diagnosis and prognostic biomarkers and to explore novel therapeutic approaches to improve the prognosis of HCC patients. Circular RNA (CircRNA), a class of plentiful, stable, and highly conserved ncRNA subgroup with the covalent closed loop, is dysregulated in HCC. Increasingly, emerging evidence have confirmed that dysregulated circRNAs can regulate gene expression at the transcriptional or post-transcriptional level, mediating various malignant biological behaviors of HCC cells, including proliferation, invasion, metastasis, immune escape, stemness, and drug resistance, etc.; meanwhile, they are regarded as potential biomarkers for early diagnosis and prognostic evaluation of HCC. This article reviews the research progress of circRNAs in HCC, expounding the potential molecular mechanisms of dysregulated circRNAs in the carcinogenesis and development of HCC, and discusses those application prospects in the diagnosis and prognosis of HCC.https://www.frontiersin.org/articles/10.3389/fonc.2021.714665/fullcircular RNAshepatocellular carcinomaspongebiomarkerdiagnosisprognosis |
| spellingShingle | Ziyue Huang Haoming Xia Shuqiang Liu Xudong Zhao Risheng He Zhongrui Wang Wenguang Shi Wangming Chen Pengcheng Kang Zhilei Su Yunfu Cui Judy Wai Ping Yam Yi Xu Yi Xu Yi Xu The Mechanism and Clinical Significance of Circular RNAs in Hepatocellular Carcinoma Frontiers in Oncology circular RNAs hepatocellular carcinoma sponge biomarker diagnosis prognosis |
| title | The Mechanism and Clinical Significance of Circular RNAs in Hepatocellular Carcinoma |
| title_full | The Mechanism and Clinical Significance of Circular RNAs in Hepatocellular Carcinoma |
| title_fullStr | The Mechanism and Clinical Significance of Circular RNAs in Hepatocellular Carcinoma |
| title_full_unstemmed | The Mechanism and Clinical Significance of Circular RNAs in Hepatocellular Carcinoma |
| title_short | The Mechanism and Clinical Significance of Circular RNAs in Hepatocellular Carcinoma |
| title_sort | mechanism and clinical significance of circular rnas in hepatocellular carcinoma |
| topic | circular RNAs hepatocellular carcinoma sponge biomarker diagnosis prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.714665/full |
| work_keys_str_mv | AT ziyuehuang themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT haomingxia themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT shuqiangliu themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT xudongzhao themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT rishenghe themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT zhongruiwang themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT wenguangshi themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT wangmingchen themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT pengchengkang themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT zhileisu themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT yunfucui themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT judywaipingyam themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT yixu themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT yixu themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT yixu themechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT ziyuehuang mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT haomingxia mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT shuqiangliu mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT xudongzhao mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT rishenghe mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT zhongruiwang mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT wenguangshi mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT wangmingchen mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT pengchengkang mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT zhileisu mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT yunfucui mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT judywaipingyam mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT yixu mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT yixu mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma AT yixu mechanismandclinicalsignificanceofcircularrnasinhepatocellularcarcinoma |