Pathophysiological changes at single and multiple introduction of Ciprofloxacin solution under experimental conditions
The article presents the results of experimental biological modelling of single and subacute introduction of Ciprofloxacin to the rabbits. State of an organism of animals was estimated by biochemical, hematological, hemostatic and morphologic indices. Introduction of preparation samples was intraven...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2013-09-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/1666 |
| _version_ | 1826853487312371712 |
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| author | A. G. Yushkov M. M. Rasulov P. A. Storozhenko G. G. Yushkov N. A. Shulgina A. A. Gushchina |
| author_facet | A. G. Yushkov M. M. Rasulov P. A. Storozhenko G. G. Yushkov N. A. Shulgina A. A. Gushchina |
| author_sort | A. G. Yushkov |
| collection | DOAJ |
| description | The article presents the results of experimental biological modelling of single and subacute introduction of Ciprofloxacin to the rabbits. State of an organism of animals was estimated by biochemical, hematological, hemostatic and morphologic indices. Introduction of preparation samples was intravenous, according to the Instruction of medical use. Main result of the experiments is determination of toxic effects that are typical for fluorinequinolone and developed on the background of multiple introduction of preparation in the doses higher than therapeutic. |
| first_indexed | 2024-03-08T12:20:16Z |
| format | Article |
| id | doaj.art-cb4326fa9608471bb5bb7d72daa94a31 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2025-02-16T17:27:47Z |
| publishDate | 2013-09-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-cb4326fa9608471bb5bb7d72daa94a312025-01-27T16:48:45ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962013-09-01051671711612Pathophysiological changes at single and multiple introduction of Ciprofloxacin solution under experimental conditionsA. G. Yushkov0M. M. Rasulov1P. A. Storozhenko2G. G. Yushkov3N. A. Shulgina4A. A. Gushchina5Scientific Center of Reconstructive and Restorative Surgery SB RAMSState Research Institute for Chemistry and Technology of Organoelement CompoundsState Research Institute for Chemistry and Technology of Organoelement CompoundsAngarsk State Technical AcademyAngarsk State Technical AcademyAngarsk State Technical AcademyThe article presents the results of experimental biological modelling of single and subacute introduction of Ciprofloxacin to the rabbits. State of an organism of animals was estimated by biochemical, hematological, hemostatic and morphologic indices. Introduction of preparation samples was intravenous, according to the Instruction of medical use. Main result of the experiments is determination of toxic effects that are typical for fluorinequinolone and developed on the background of multiple introduction of preparation in the doses higher than therapeutic.https://www.actabiomedica.ru/jour/article/view/1666ciprofloxacintoxicological research |
| spellingShingle | A. G. Yushkov M. M. Rasulov P. A. Storozhenko G. G. Yushkov N. A. Shulgina A. A. Gushchina Pathophysiological changes at single and multiple introduction of Ciprofloxacin solution under experimental conditions Acta Biomedica Scientifica ciprofloxacin toxicological research |
| title | Pathophysiological changes at single and multiple introduction of Ciprofloxacin solution under experimental conditions |
| title_full | Pathophysiological changes at single and multiple introduction of Ciprofloxacin solution under experimental conditions |
| title_fullStr | Pathophysiological changes at single and multiple introduction of Ciprofloxacin solution under experimental conditions |
| title_full_unstemmed | Pathophysiological changes at single and multiple introduction of Ciprofloxacin solution under experimental conditions |
| title_short | Pathophysiological changes at single and multiple introduction of Ciprofloxacin solution under experimental conditions |
| title_sort | pathophysiological changes at single and multiple introduction of ciprofloxacin solution under experimental conditions |
| topic | ciprofloxacin toxicological research |
| url | https://www.actabiomedica.ru/jour/article/view/1666 |
| work_keys_str_mv | AT agyushkov pathophysiologicalchangesatsingleandmultipleintroductionofciprofloxacinsolutionunderexperimentalconditions AT mmrasulov pathophysiologicalchangesatsingleandmultipleintroductionofciprofloxacinsolutionunderexperimentalconditions AT pastorozhenko pathophysiologicalchangesatsingleandmultipleintroductionofciprofloxacinsolutionunderexperimentalconditions AT ggyushkov pathophysiologicalchangesatsingleandmultipleintroductionofciprofloxacinsolutionunderexperimentalconditions AT nashulgina pathophysiologicalchangesatsingleandmultipleintroductionofciprofloxacinsolutionunderexperimentalconditions AT aagushchina pathophysiologicalchangesatsingleandmultipleintroductionofciprofloxacinsolutionunderexperimentalconditions |