Mathematical modelling of activation-induced heterogeneity in TNF, IL6, NOS2, and IL1β expression reveals cell state transitions underpinning macrophage responses to LPS [version 2; peer review: 2 approved]

Mathematical modelling of activation-induced heterogeneity in TNF, IL6, NOS2, and IL1β expression reveals cell state transitions underpinning macrophage responses to LPS [version 2; peer review: 2 approved]

Background: Despite extensive work on macrophage heterogeneity, the mechanisms driving activation induced heterogeneity (AIH) in macrophages remain poorly understood. Here, we aimed to develop mathematical models to explore theoretical cellular states underpinning the empirically observed responses...

Full description

Bibliographic Details
Main Authors:	Dave Boucher, Shoumit Dey, Dimitris Lagos, Jon Pitchford
Format:	Article
Language:	English
Published:	Wellcome 2022-07-01
Series:	Wellcome Open Research
Subjects:	mathematical modelling macrophage heterogeneity activation induced heterogeneity TNF IL6 NOS2 eng
Online Access:	https://wellcomeopenresearch.org/articles/7-29/v2

Similar Items

Level Of Cytokines (Like IL-1 , IL-6 , IL-8 And TNF- ) In Platelet Concentrates
by: Shayegan M, et al.
Published: (2004-09-01)

Serum concentration of IL-6, IL-2, TNF-α, and IFNγ in Vitiligo patients
by: Suman Singh, et al.
Published: (2012-01-01)

Effect of antidiabetic therapy on TNF-α, IL-18, IL-23 and IL-35 levels in T2DM patients with coincidental Helicobacter pylori infection
by: Adel Abdel-Moneim, et al.
Published: (2020-01-01)

Otimização de metodologia PCR-SSP para identificação de polimorfismos genéticos de TNF e IL2 Optimization of the PCR-SSP methodology in the identification of TNF and IL2 genetic polymorphisms
by: Danilo A. S. Franceschi, et al.
Published: (2009-08-01)

A Study Correlation between Levels IL-15, IL-23 and TNF-α in a Sample of Iraqi Psoriasis Patients
by: Samara Amar Sabri, et al.
Published: (2024-01-01)

Effects of Cyclosporine on Palmoplantar Pustulosis and Serum Expression of IL-17, IL-23, and TNF-α
by: Xian-Hua Jin, et al.
Published: (2019-06-01)

Effect of lactoferrin in oral nutrition supplement (ONS) towards IL-6 and IL-10 in failure to thrive children with infection [version 3; peer review: 2 approved]
by: Nur Aisiyah Widjaja, et al.
Published: (2023-12-01)

Plasma levels of IL-6, IL-10, IL-18, TNFα under the conditions of tobacco intoxication and after treatment with aminophthalhydrazide
by: O. V. Alpidovskaya
Published: (2024-04-01)

IL-6, IL-8 and TNF-α expression levels in serum and aqueous humor in patients with neovascular glaucoma and their significance
by: Ayinuer·Aimaier, et al.
Published: (2018-08-01)

Association of TNF-α, IFN-γ, IL-6, and IL-10 with different clinical manifestations of hepatitis B infection
by: Mudathir Abdelshafea Abdelkareem Abakar, et al.
Published: (2023-07-01)

IL‐6, TNF‐α, IL‐10, and nutritional status in pediatric patients with biliary atresia
by: Maria Ines de Albuquerque Wilasco, et al.
Published: (2017-09-01)

IL-6, TNF-α, IL-10, and nutritional status in pediatric patients with biliary atresia,
by: Maria Ines de Albuquerque Wilasco, et al.

Assessment of the levels of nitric oxide (NO) and cytokines (IL-5, IL-6, IL-13, TNF, IFN-gamma) in <i>giardiosis</i>
by: Halina Kemona, et al.
Published: (2011-07-01)

Study of the association of seventeen single nucleotide polymorphisms and their haplotypes in the TNF-α, IL-2, IL-4 and IL-10 genes with the antibody response to inactivated Japanese encephalitis vaccine
by: Yufeng Yao, et al.
Published: (2020-10-01)

Levels of pro-inflammatory (TNF-α and IL -6) and anti-inflammatory (IL -10 and IL- 4) interleukins in ocular herpes patients with frequent and infrequent recurrences
by: N. I. Khramenko, et al.
Published: (2020-10-01)

Clinical value of TNF, IL-6, and IL-10 gene polymorphic markers in chronic glomerulonephritis
by: E S Kamyshova, et al.
Published: (2016-06-01)

Study of the correlation between the expression levels of IL-6 and TNF-α, and the severity of acne in acne patients
by: Huifang MO, et al.
Published: (2021-06-01)

DIAGNOSTIC AND PREDICTIVE VALUE OF TNF Α, IL-8 AND IL-6 ASSAYS IN THE PATIENTS WITH MYCOPLASMA-ASSOCIATED PNEUMONIAS
by: T. I. Dolgikh, et al.
Published: (2014-07-01)

THE ROLE OF TNF-α AND IL-6 CYTOKINE IN CHILDREN WITH STATUS EPILEPTICUS
by: Agung Prasetyo Wibowo, et al.
Published: (2018-04-01)

PROGNOSIS FOR PREDISPOSAL TO DEVELOPMENT OF VIRAL HEPATITIS C BASED ON G-308A TNFА, T-330G IL-2, С-590Т IL-4, С-703Т IL-5, AND C-592A IL-10 GENE POLYMORPHISMS
by: V. V. Avdoshina, et al.
Published: (2014-07-01)

Association analysis of IL10, TNF-α and IL23R-IL12RB2 SNPs with Behçet's disease risk in Western Algeria
by: Ouahiba eKhaib Dit Naib, et al.
Published: (2013-10-01)

The stock market reaction to COVID-19 vaccination in ASEAN [version 2; peer review: 1 approved, 2 approved with reservations]
by: Marizsa Herlina, et al.
Published: (2023-04-01)

Correlation of the Pro-Inflammatory Cytokines IL-1β, IL-6, and TNF-α, Inflammatory Markers, and Tumor Markers with the Diagnosis and Prognosis of Colorectal Cancer
by: Dan Nicolae Florescu, et al.
Published: (2023-11-01)

Impact of TNF and IL-33 Cytokines on Mast Cells in Neuroinflammation
by: Pio Conti, et al.
Published: (2024-03-01)

Assessment of IL6 and TNF α in Chronic Lymphocytic Leukemia
by: Mohamed Abd-El-Haleem Mousa, et al.
Published: (2022-10-01)

Recurrent pregnancy loss: TNF-α and IL-10 polymorphisms
by: Amrit Kaur, et al.
Published: (2011-01-01)

The role of IL-6, ferritin, and coagulopathy in Covid-19 clinical progression [version 2; peer review: 2 approved]
by: Cosphiadi Irawan, et al.
Published: (2023-09-01)

Allopurinol Protective Effect of Renal Ischemia by Downregulating TNF-α, IL-1β, and IL-6 Response
by: Beatriz Prieto-Moure, et al.
Published: (2017-05-01)

Influenza A (H1N1) virus infection and TNF-308, IL6, and IL8 polymorphisms in Egyptian population: a case–control study
by: Shaimaa Moustafa Elsayed, et al.
Published: (2019-11-01)

Serum levels of cytokines (TNF-α, IFN-γ& IL-10) in Type-2 diabetic patients with HCV infection
by: May Y. Saour, et al.
Published: (2011-07-01)

The Relation Between Levels of TNF Alpha, IL-1B, PGE2 and PLA with the Severity Degree of Dengue Hemorrhagic
by: . PURWATI, et al.
Published: (2011-10-01)

TNFα-Signaling Modulates the Kinase Activity of Human Effector Treg and Regulates IL-17A Expression
by: Paulo C. M. Urbano, et al.
Published: (2020-01-01)

Effect of Histone Deacetylase HDAC3 on Cytokines IL-18, IL-12 and TNF-α in Patients with Intrahepatic Cholestasis of Pregnancy
by: Yong Shao, et al.
Published: (2017-07-01)

Increased expression of IL-37 correlates with TNF-α levels and disease stage in endometriosis patients
by: Dina Ragab, et al.
Published: (2022-03-01)

Effect of Plant Extracts Combinations on TNF-α, IL-6 and IL-10 Levels in Serum of Rats Exposed to Acute and Chronic Stress
by: Ilin Kandilarov, et al.
Published: (2023-08-01)

Aging as a Risk Factor on the Immunoexpression of Pro-Inflammatory IL-1β, IL-6 and TNF-α Cytokines in Chronic Apical Periodontitis Lesions
by: Quésia Euclides Teixeira, et al.
Published: (2021-12-01)

Elevated levels of TNF-α, IL-1β and IL-6 in the synovial tissue of patients with labral tear: a comparative study with hip osteoarthritis
by: Tomohisa Koyama, et al.
Published: (2021-01-01)

Integration of single-cell RNA sequencing and spatial transcriptomics to reveal the glioblastoma heterogeneity [version 2; peer review: 2 approved, 1 approved with reservations]
by: Bozena Kaminska, et al.
Published: (2023-08-01)

Evaluating TNF-α and Interleukin-2 (IL-2) Levels in African American Primary Open-Angle Glaucoma Patients
by: Teja Alapati, et al.
Published: (2021-12-01)

Are circadian amplitudes and periods correlated? A new twist in the story [version 1; peer review: 2 approved]
by: Hanspeter Herzel, et al.
Published: (2023-08-01)