Genomic Epidemiology and Evolution of Fowl Adenovirus 1
Fowl adenovirus 1 (FAdV-1) is the main cause of gizzard erosion in chickens. Whole genome sequencing and sequence analyses of 32 FAdV-1 strains from a global collection provided evidence that multiple recombination events have occurred along the entire genome. In gene-wise phylogenies, only the aden...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/18/2819 |
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| author | Szilvia Jakab Krisztina Bali Zalán Homonnay Eszter Kaszab Katalin Ihász Enikő Fehér Tamás Mató István Kiss Vilmos Palya Krisztián Bányai |
| author_facet | Szilvia Jakab Krisztina Bali Zalán Homonnay Eszter Kaszab Katalin Ihász Enikő Fehér Tamás Mató István Kiss Vilmos Palya Krisztián Bányai |
| author_sort | Szilvia Jakab |
| collection | DOAJ |
| description | Fowl adenovirus 1 (FAdV-1) is the main cause of gizzard erosion in chickens. Whole genome sequencing and sequence analyses of 32 FAdV-1 strains from a global collection provided evidence that multiple recombination events have occurred along the entire genome. In gene-wise phylogenies, only the adenoviral pol gene formed a tree topology that corresponded to whole genome-based phylogeny. Virus genetic features that were clearly connected to gizzard erosion were not identified in our analyses. However, some genome variants tended to be more frequently identified from birds with gizzard erosion and strains isolated from healthy birds or birds with non-specific pathologies tended to form common clusters in multiple gene phylogenies. Our data show that the genetic diversity is greater, and the evolutionary mechanisms are more complex within FAdV-1 than previously thought. The implications of these findings for viral pathogenesis and epidemiology await further investigation. |
| first_indexed | 2024-03-10T23:07:53Z |
| format | Article |
| id | doaj.art-cb447e23639d4fb8931b92cfe3495b6b |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T23:07:53Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-cb447e23639d4fb8931b92cfe3495b6b2023-11-19T09:14:03ZengMDPI AGAnimals2076-26152023-09-011318281910.3390/ani13182819Genomic Epidemiology and Evolution of Fowl Adenovirus 1Szilvia Jakab0Krisztina Bali1Zalán Homonnay2Eszter Kaszab3Katalin Ihász4Enikő Fehér5Tamás Mató6István Kiss7Vilmos Palya8Krisztián Bányai9Veterinary Medical Research Institute, Hungária krt. 21, H-1143 Budapest, HungaryVeterinary Medical Research Institute, Hungária krt. 21, H-1143 Budapest, HungaryCeva-Phylaxia Ltd., Szállás u. 5, H-1107 Budapest, HungaryVeterinary Medical Research Institute, Hungária krt. 21, H-1143 Budapest, HungaryVeterinary Medical Research Institute, Hungária krt. 21, H-1143 Budapest, HungaryVeterinary Medical Research Institute, Hungária krt. 21, H-1143 Budapest, HungaryCeva-Phylaxia Ltd., Szállás u. 5, H-1107 Budapest, HungaryCeva-Phylaxia Ltd., Szállás u. 5, H-1107 Budapest, HungaryCeva-Phylaxia Ltd., Szállás u. 5, H-1107 Budapest, HungaryVeterinary Medical Research Institute, Hungária krt. 21, H-1143 Budapest, HungaryFowl adenovirus 1 (FAdV-1) is the main cause of gizzard erosion in chickens. Whole genome sequencing and sequence analyses of 32 FAdV-1 strains from a global collection provided evidence that multiple recombination events have occurred along the entire genome. In gene-wise phylogenies, only the adenoviral pol gene formed a tree topology that corresponded to whole genome-based phylogeny. Virus genetic features that were clearly connected to gizzard erosion were not identified in our analyses. However, some genome variants tended to be more frequently identified from birds with gizzard erosion and strains isolated from healthy birds or birds with non-specific pathologies tended to form common clusters in multiple gene phylogenies. Our data show that the genetic diversity is greater, and the evolutionary mechanisms are more complex within FAdV-1 than previously thought. The implications of these findings for viral pathogenesis and epidemiology await further investigation.https://www.mdpi.com/2076-2615/13/18/2819<i>Fowl adenovirus A</i>gizzard erosiongenotypingphylogenetic analysisrecombination |
| spellingShingle | Szilvia Jakab Krisztina Bali Zalán Homonnay Eszter Kaszab Katalin Ihász Enikő Fehér Tamás Mató István Kiss Vilmos Palya Krisztián Bányai Genomic Epidemiology and Evolution of Fowl Adenovirus 1 Animals <i>Fowl adenovirus A</i> gizzard erosion genotyping phylogenetic analysis recombination |
| title | Genomic Epidemiology and Evolution of Fowl Adenovirus 1 |
| title_full | Genomic Epidemiology and Evolution of Fowl Adenovirus 1 |
| title_fullStr | Genomic Epidemiology and Evolution of Fowl Adenovirus 1 |
| title_full_unstemmed | Genomic Epidemiology and Evolution of Fowl Adenovirus 1 |
| title_short | Genomic Epidemiology and Evolution of Fowl Adenovirus 1 |
| title_sort | genomic epidemiology and evolution of fowl adenovirus 1 |
| topic | <i>Fowl adenovirus A</i> gizzard erosion genotyping phylogenetic analysis recombination |
| url | https://www.mdpi.com/2076-2615/13/18/2819 |
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