A Reliable and Rapid Language Tool for the Diagnosis, Classification, and Follow-Up of Primary Progressive Aphasia Variants
Background: Primary progressive aphasias (PPA) have been investigated by clinical, therapeutic, and fundamental research but examiner-consistent language tests for reliable reproducible diagnosis and follow-up are lacking.Methods: We developed and evaluated a rapid language test for PPA (“PARIS”) as...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2020.571657/full |
| _version_ | 1818951403605852160 |
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| author | Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Yasmina Michel Saade Constance Flamand Roze Emmanuel Roze Emmanuel Roze Sophie Ferrieux Céline Arbizu Marie Nogues Carole Azuar Carole Azuar Bruno Dubois Bruno Dubois Sophie Tezenas du Montcel Marc Teichmann Marc Teichmann |
| author_facet | Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Yasmina Michel Saade Constance Flamand Roze Emmanuel Roze Emmanuel Roze Sophie Ferrieux Céline Arbizu Marie Nogues Carole Azuar Carole Azuar Bruno Dubois Bruno Dubois Sophie Tezenas du Montcel Marc Teichmann Marc Teichmann |
| author_sort | Stéphane Epelbaum |
| collection | DOAJ |
| description | Background: Primary progressive aphasias (PPA) have been investigated by clinical, therapeutic, and fundamental research but examiner-consistent language tests for reliable reproducible diagnosis and follow-up are lacking.Methods: We developed and evaluated a rapid language test for PPA (“PARIS”) assessing its inter-examiner consistency, its power to detect and classify PPA, and its capacity to identify language decline after a follow-up of 9 months. To explore the reliability and specificity/sensitivity of the test it was applied to PPA patients (N = 36), typical amnesic Alzheimer's disease (AD) patients (N = 24) and healthy controls (N = 35), while comparing it to two rapid examiner-consistent language tests used in stroke-induced aphasia (“LAST”, “ART”).Results: The application duration of the “PARIS” was ~10 min and its inter-rater consistency was of 88%. The three tests distinguished healthy controls from AD and PPA patients but only the “PARIS” reliably separated PPA from AD and allowed for classifying the two most frequent PPA variants: semantic and logopenic PPA. Compared to the “LAST” and “ART,” the “PARIS” also had the highest sensitivity for detecting language decline.Conclusions: The “PARIS” is an efficient, rapid, and highly examiner-consistent language test for the diagnosis, classification, and follow-up of frequent PPA variants. It might also be a valuable tool for providing end-points in future therapeutic trials on PPA and other neurodegenerative diseases affecting language processing. |
| first_indexed | 2024-12-20T09:33:56Z |
| format | Article |
| id | doaj.art-cb45851f4dcd4a69a986773ca576c0be |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-20T09:33:56Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-cb45851f4dcd4a69a986773ca576c0be2022-12-21T19:45:03ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-01-011110.3389/fneur.2020.571657571657A Reliable and Rapid Language Tool for the Diagnosis, Classification, and Follow-Up of Primary Progressive Aphasia VariantsStéphane Epelbaum0Stéphane Epelbaum1Stéphane Epelbaum2Yasmina Michel Saade3Constance Flamand Roze4Emmanuel Roze5Emmanuel Roze6Sophie Ferrieux7Céline Arbizu8Marie Nogues9Carole Azuar10Carole Azuar11Bruno Dubois12Bruno Dubois13Sophie Tezenas du Montcel14Marc Teichmann15Marc Teichmann16Department of Neurology, National Reference Center for “PPA and rare dementias”, Institute for Memory and Alzheimer's Disease, Pitié Salpêtrière Hospital, AP-HP, Paris, FranceInstitut du Cerveau, ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne Université, Paris, FranceInria, Aramis-project team, ‘APHP-INRIA collaboration’, Paris, FranceDepartment of Neurology, National Reference Center for “PPA and rare dementias”, Institute for Memory and Alzheimer's Disease, Pitié Salpêtrière Hospital, AP-HP, Paris, FranceCentre Hospitalier Sud-Francilien, Université Paris Sud, Corbeil-Essonnes, Service de Neurologie et Unité Neurovasculaire, Corbeil-Essonnes, FranceInstitut du Cerveau, ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne Université, Paris, FranceDepartment of Neurology, Pitié Salpêtrière Hospital, AP-HP, Paris, FranceDepartment of Neurology, National Reference Center for “PPA and rare dementias”, Institute for Memory and Alzheimer's Disease, Pitié Salpêtrière Hospital, AP-HP, Paris, FranceDepartment of Neurology, National Reference Center for “PPA and rare dementias”, Institute for Memory and Alzheimer's Disease, Pitié Salpêtrière Hospital, AP-HP, Paris, FranceDepartment of Neurology, National Reference Center for “PPA and rare dementias”, Institute for Memory and Alzheimer's Disease, Pitié Salpêtrière Hospital, AP-HP, Paris, FranceDepartment of Neurology, National Reference Center for “PPA and rare dementias”, Institute for Memory and Alzheimer's Disease, Pitié Salpêtrière Hospital, AP-HP, Paris, FranceInstitut du Cerveau, ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne Université, Paris, FranceDepartment of Neurology, National Reference Center for “PPA and rare dementias”, Institute for Memory and Alzheimer's Disease, Pitié Salpêtrière Hospital, AP-HP, Paris, FranceInstitut du Cerveau, ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne Université, Paris, FranceSorbonne Université, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Paris, FranceDepartment of Neurology, National Reference Center for “PPA and rare dementias”, Institute for Memory and Alzheimer's Disease, Pitié Salpêtrière Hospital, AP-HP, Paris, FranceInstitut du Cerveau, ICM, INSERM U 1127, CNRS UMR 7225, Sorbonne Université, Paris, FranceBackground: Primary progressive aphasias (PPA) have been investigated by clinical, therapeutic, and fundamental research but examiner-consistent language tests for reliable reproducible diagnosis and follow-up are lacking.Methods: We developed and evaluated a rapid language test for PPA (“PARIS”) assessing its inter-examiner consistency, its power to detect and classify PPA, and its capacity to identify language decline after a follow-up of 9 months. To explore the reliability and specificity/sensitivity of the test it was applied to PPA patients (N = 36), typical amnesic Alzheimer's disease (AD) patients (N = 24) and healthy controls (N = 35), while comparing it to two rapid examiner-consistent language tests used in stroke-induced aphasia (“LAST”, “ART”).Results: The application duration of the “PARIS” was ~10 min and its inter-rater consistency was of 88%. The three tests distinguished healthy controls from AD and PPA patients but only the “PARIS” reliably separated PPA from AD and allowed for classifying the two most frequent PPA variants: semantic and logopenic PPA. Compared to the “LAST” and “ART,” the “PARIS” also had the highest sensitivity for detecting language decline.Conclusions: The “PARIS” is an efficient, rapid, and highly examiner-consistent language test for the diagnosis, classification, and follow-up of frequent PPA variants. It might also be a valuable tool for providing end-points in future therapeutic trials on PPA and other neurodegenerative diseases affecting language processing.https://www.frontiersin.org/articles/10.3389/fneur.2020.571657/fullprimary progressive aphasiaAlzheiemer's diseaselanguagetestdiagnosis |
| spellingShingle | Stéphane Epelbaum Stéphane Epelbaum Stéphane Epelbaum Yasmina Michel Saade Constance Flamand Roze Emmanuel Roze Emmanuel Roze Sophie Ferrieux Céline Arbizu Marie Nogues Carole Azuar Carole Azuar Bruno Dubois Bruno Dubois Sophie Tezenas du Montcel Marc Teichmann Marc Teichmann A Reliable and Rapid Language Tool for the Diagnosis, Classification, and Follow-Up of Primary Progressive Aphasia Variants Frontiers in Neurology primary progressive aphasia Alzheiemer's disease language test diagnosis |
| title | A Reliable and Rapid Language Tool for the Diagnosis, Classification, and Follow-Up of Primary Progressive Aphasia Variants |
| title_full | A Reliable and Rapid Language Tool for the Diagnosis, Classification, and Follow-Up of Primary Progressive Aphasia Variants |
| title_fullStr | A Reliable and Rapid Language Tool for the Diagnosis, Classification, and Follow-Up of Primary Progressive Aphasia Variants |
| title_full_unstemmed | A Reliable and Rapid Language Tool for the Diagnosis, Classification, and Follow-Up of Primary Progressive Aphasia Variants |
| title_short | A Reliable and Rapid Language Tool for the Diagnosis, Classification, and Follow-Up of Primary Progressive Aphasia Variants |
| title_sort | reliable and rapid language tool for the diagnosis classification and follow up of primary progressive aphasia variants |
| topic | primary progressive aphasia Alzheiemer's disease language test diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2020.571657/full |
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