Differences in l-arginine metabolism and asthma morbidity among asthma patients with and without obstructive sleep apnea
Abstract Background Imbalance in l-arginine and nitric oxide (NO) metabolism has been implicated in the pathophysiology of asthma and obstructive sleep apnea (OSA), and both diseases impact the other’s morbidity. We sought to determine whether l-arginine/NO metabolism differs between adults with ast...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-022-02157-9 |
| _version_ | 1811211747181199360 |
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| author | Meghan D. Althoff Guillermo Jimenez Ryan Peterson Ying Jin Hartmut Grasemann Sunita Sharma Alex D. Federman Juan P. Wisnivesky Fernando Holguin |
| author_facet | Meghan D. Althoff Guillermo Jimenez Ryan Peterson Ying Jin Hartmut Grasemann Sunita Sharma Alex D. Federman Juan P. Wisnivesky Fernando Holguin |
| author_sort | Meghan D. Althoff |
| collection | DOAJ |
| description | Abstract Background Imbalance in l-arginine and nitric oxide (NO) metabolism has been implicated in the pathophysiology of asthma and obstructive sleep apnea (OSA), and both diseases impact the other’s morbidity. We sought to determine whether l-arginine/NO metabolism differs between adults with asthma with or without comorbid OSA, and its association with asthma morbidity. Methods This is a cross-sectional study of 322 adults with asthma recruited in Denver, CO and New York City, NY. Data were collected on OSA status, spirometry, and metrics of asthma control and morbidity. l-Arginine metabolites were quantified in patient serum. Bivariate analyses and multiple regression were performed to determine differences between l-arginine metabolism, OSA and association with asthma morbidity. Results Among the 322 participants, 92 (28.5%) had OSA. The cohort was 81.6% female, 23.4% identified as Black and 30.6% as Latino. Patients with asthma and OSA had significantly higher serum concentrations of NO synthase inhibitor asymmetric dimethylarginine (ADMA) (p-value = 0.019), lower L-arginine to ornithine ratios (p-value = 0.003), and increased ornithine (p-value = 0.001) and proline levels (p-value < 0.001) compared to those without OSA. In adjusted models, OSA was associated with worse asthma control, adjusted mean difference in asthma control questionnaire of 0.36 (95% confidence interval [CI]: 0.06 to 0.65), and asthma quality of life questionnaire, adjusted mean difference: − 0.53 (95% CI: − 0.85 to − 0.21), after adjusting for relevant covariates including body mass index and L-arginine metabolites. Conclusions Adults with asthma and OSA had increased ADMA, an inhibitor of nitric oxide synthase, and greater metabolism of l-arginine via the arginase pathway compared to those with asthma alone, indicating a possible shared pathophysiological mechanism of these diseases. |
| first_indexed | 2024-04-12T05:17:22Z |
| format | Article |
| id | doaj.art-cb4730f16a4344ed87edbe6b353e59b4 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-04-12T05:17:22Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-cb4730f16a4344ed87edbe6b353e59b42022-12-22T03:46:35ZengBMCRespiratory Research1465-993X2022-09-012311810.1186/s12931-022-02157-9Differences in l-arginine metabolism and asthma morbidity among asthma patients with and without obstructive sleep apneaMeghan D. Althoff0Guillermo Jimenez1Ryan Peterson2Ying Jin3Hartmut Grasemann4Sunita Sharma5Alex D. Federman6Juan P. Wisnivesky7Fernando Holguin8Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz School of MedicineDepartment of Medicine, University of Colorado Anschutz School of MedicineDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz School of MedicineDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz School of MedicineDivision of Respiratory Medicine, Department of Pediatrics, Hospital for Sick ChildrenDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz School of MedicineDivision of General Internal Medicine, Icahn School of Medicine at Mount SinaiDivision of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount SinaiDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz School of MedicineAbstract Background Imbalance in l-arginine and nitric oxide (NO) metabolism has been implicated in the pathophysiology of asthma and obstructive sleep apnea (OSA), and both diseases impact the other’s morbidity. We sought to determine whether l-arginine/NO metabolism differs between adults with asthma with or without comorbid OSA, and its association with asthma morbidity. Methods This is a cross-sectional study of 322 adults with asthma recruited in Denver, CO and New York City, NY. Data were collected on OSA status, spirometry, and metrics of asthma control and morbidity. l-Arginine metabolites were quantified in patient serum. Bivariate analyses and multiple regression were performed to determine differences between l-arginine metabolism, OSA and association with asthma morbidity. Results Among the 322 participants, 92 (28.5%) had OSA. The cohort was 81.6% female, 23.4% identified as Black and 30.6% as Latino. Patients with asthma and OSA had significantly higher serum concentrations of NO synthase inhibitor asymmetric dimethylarginine (ADMA) (p-value = 0.019), lower L-arginine to ornithine ratios (p-value = 0.003), and increased ornithine (p-value = 0.001) and proline levels (p-value < 0.001) compared to those without OSA. In adjusted models, OSA was associated with worse asthma control, adjusted mean difference in asthma control questionnaire of 0.36 (95% confidence interval [CI]: 0.06 to 0.65), and asthma quality of life questionnaire, adjusted mean difference: − 0.53 (95% CI: − 0.85 to − 0.21), after adjusting for relevant covariates including body mass index and L-arginine metabolites. Conclusions Adults with asthma and OSA had increased ADMA, an inhibitor of nitric oxide synthase, and greater metabolism of l-arginine via the arginase pathway compared to those with asthma alone, indicating a possible shared pathophysiological mechanism of these diseases.https://doi.org/10.1186/s12931-022-02157-9AsthmaSleep apneaClinical epidemiologyAsthma epidemiology |
| spellingShingle | Meghan D. Althoff Guillermo Jimenez Ryan Peterson Ying Jin Hartmut Grasemann Sunita Sharma Alex D. Federman Juan P. Wisnivesky Fernando Holguin Differences in l-arginine metabolism and asthma morbidity among asthma patients with and without obstructive sleep apnea Respiratory Research Asthma Sleep apnea Clinical epidemiology Asthma epidemiology |
| title | Differences in l-arginine metabolism and asthma morbidity among asthma patients with and without obstructive sleep apnea |
| title_full | Differences in l-arginine metabolism and asthma morbidity among asthma patients with and without obstructive sleep apnea |
| title_fullStr | Differences in l-arginine metabolism and asthma morbidity among asthma patients with and without obstructive sleep apnea |
| title_full_unstemmed | Differences in l-arginine metabolism and asthma morbidity among asthma patients with and without obstructive sleep apnea |
| title_short | Differences in l-arginine metabolism and asthma morbidity among asthma patients with and without obstructive sleep apnea |
| title_sort | differences in l arginine metabolism and asthma morbidity among asthma patients with and without obstructive sleep apnea |
| topic | Asthma Sleep apnea Clinical epidemiology Asthma epidemiology |
| url | https://doi.org/10.1186/s12931-022-02157-9 |
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